건국의료원 서울병원 산부인과에서 조직검사 및 수술로 진단받은 환자 중 파라핀 포매조직을 얻을 수 있었던 침윤성 자궁경부암 43예를 대상으로 면역조직화학염색법을 이용한 p53 과발현에 관한 연구 결과로 다음과 같은 결론을 얻었다, 1. p53 과발현의 정도는 자궁경부암의 여러 임상 적 예후인자인 임상적 병기, 조직학적 유형 및 병소 크기와의 관계에서 통계학적 의의가 없었다.

The p53 gene is a tumor suppressor gene and mutations in this gene play an import-ant role in the development of many human malignancies. The purpose of this study was to investigate the overexpression of p53 protein as a prognostic factor in invasive cervical cancer. Forty-three formalin fixed, paraffin wax embedded blocks of invasive cervical can-cers were examined using immunohistochemical staining with a monoclonal antibody against p53. The result were as follows： 1. Immunostaining for p53 consistent with overexpression was seen in 23.8%(5 of 21) of stage Ⅰ cancers and in 13.7%(4 of 22) of stage Ⅱ cancers. 2. Immunostaining for p53 consistent with overexpression was seen in 21.6%(8 of 37) of squamous cell carciomas and in 0%(0 of 6) of adenocarcinomas. 3. The incidence of p53 overexpression was 25.0%(1 of 4) in cases with lymph node metastasis, compared with 17.9%(7 of 39) in cases without lymph node metastasis. 4.. The incidence of p53 overexpression was 20.0%(8 of 40) in cases with less than 4 cm, compared with 0%(0 of 3) in cases with equal to or larger than 4cm. In conclusion, p53 overexpression was not associated with stage, histologic type, and tumor size. However, there were trend for p53 overexpression to increase in patients with lymph node metastasis.