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증례: 가족성 한랭 두드러기 1례

이지호 , 박영민 , 김태윤 , 김형옥 , 김정원
  • : 대한천식알레르기학회(구 대한알레르기학회)
  • : 천식 및 알레르기 16권4호
  • : 연속간행물
  • : 1996년 11월
  • : 548-552(5pages)

DOI


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Familial cold urticaria is a rare abnormal cutaneous and systemic reaction to cold with autosomal dominant inheritance, distinctive clinical features, and unknown etiology. A 21  year  old male patient presented with generalized erythematous macules and papules accompanied by burning, chills and arthralgia after cold exposure since early childhood. Autosomsl dominant inheritance was revealed on the examination of his pedigree. Autosomal dominant inheritance was revealed on the examination of his pedigree. Cold room challenge induced the same lesions after a delay of 20 min. Histopathologic findings showed a perivascular polymorphonuclear leukocytic infiltrstion with some eosinophils. He was treated with several antihistamines, but unsatisfaetory. We report a patient with a familial cold urticaris showing typical cutaneous manifests- tions and general symptoms with a consistent familial history through his five generations.

UCI(KEPA)

I410-ECN-0102-2009-510-005560944

간행물정보

  • : 의약학분야  > 내과학
  • :
  • :
  • : 계간
  • : 1226-8739
  • :
  • : 학술지
  • : 연속간행물
  • : 1981-2012
  • : 1614


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발행기관 최신논문
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1종설: Glucocorticoid의 항염작용의 기전

저자 : 조영주

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 467-475 (9 pages)

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2종설: 진균과 알레르기 질환

저자 : 김규언

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 476-484 (9 pages)

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3원저: Steroid 제제가 호산구 생존율에 미치는 영향

저자 : 최영수 , 이영목 , 김경호 , 김효석 , 임건일 , 문승혁 , 정성환 , 김현태 , 어수택 , 김용훈 , 박춘식

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 485-493 (9 pages)

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Objectives: To evaluate the inhibitory effect of corticosteroids including hydrocortisone, methyl- prednisolone, dexamethasone on the survival of eosinophils. Method: Eosinophils were purified from allergic patients with peripheral eosinophilia. Survival rate of eosinophils in the presence of IL  5 were measured by using flowcytometer. The inhibitory effect of corticosteroids were compared to spontaneous and IL  5 induced survival of eosinophils rates. Results: 1) Spontaneous survival rates of eosinophils rapidly decreased below 10k at the 3rd day of culture in the absence of IL  5, 2) IL  5 prolonged the survival of eosino- phils dose dependently. 3) Corticosteroids including hydrocortisone, methylprednisolone, dexamethasone did not have any inhibitory effect on the spontaneous survival of eosinophils.  4) Hydrocortisone significantly decreased IL  5  induced prolongation of eosinophil survival dose dependently. The blocking effect became apparent after the 4th day of culture. 5) Biologically equivalent dosages of hyd- rocortisone, methylprednisolone, dexamethasone had the inhibitory potency on the survival of eosinophils in descending order. Conclusion.' Corticosteroids had different effects on survival of eosinophils induced by IL  5 even when used at the concentration of biologically eqivalent dosages. The effect of corticosteroid was not immediate, but delayed upto 4 days or more.

4원저: 데오필린 , 경구 , 베타교감신경자극제 , 경구 스테로이드제가 피부단자시험에 미치는 영향

저자 : 이상록 , 반준우 , 이병재 , 손지웅 , 김우경 , 김윤근 , 지영구 , 조상헌 , 민경업 , 김유영

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 494-501 (8 pages)

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Skin prick test(SPT) is an economic and sensitive test to detect a specific IgE. Theophylline, oral beta2-agonist. Oral corticosteroids, and antihistamines are the commomly prescribed drugs in patients with allergic diseases but there are many situations that SPT are performed while taking those durgs. It has been suggested that theophylline, oral beta2- agonist, and corticosteroid inhibit the release of mediators from mast cells in vitro. To evaluate the effects of theophylline, oral Salbutamol,  and Prednisolone on the results of SPT, we measured skin resgonse to histamine codeine, and allergens before and after the mediestions of therapeutic dosage for 7 days in 10 healthy subjects. The results were as follows. L. In SPT with histamines(lmg/ml), the mean wheal sizes(mm +SE) before and after medications of theophylline, beta2-agonist, corticosteroid, and antihistmaine were 4.37+ 0.23 and 4.27+0.20, 4.17 + 0.28 and 3.87 + 0. 28, 4.49 + 0.29 and 3.98 + 0.36, and 4.82 + 0.40 and 1.82+0.35, respectively. Theophylline, bata2-agonist and corticosteroid had no significant effect on the result of SPT with histamine. 2. In SPT with codeine(10mg/ml), the mean wheal sizes(mm+-SE) before and after medications of theophylline, beta2-agonist, corticosteroid, snd antihistamines were 4.00 + 0.37 a,nd 4.05+0.26, 4.51+0.28 and 4.28+0.36 4.31+0.37 and 4.41+0.29, and 4.39+0.30 and 2.05+0.28 respectively. Theophy'Rine, beta2-agonist and corticosteroid had no significant effect on the result of SPT with codeine. 3. In SPT with allergens, the mean wheal sizes(mm +SE) before and after medications of theophylline, beta2-agonist, corticosteroid, and antihistamines were 5.86 + 0.65 and 4.95 +0.97, 6.00+0.79 and 5.58+1.17, 5.12+0.70 and 4.09 + 0.60, and 5.72 + 0.67 and 3.05 + 0. 37, respectively. Theophylline, beta2-agonist and corticosteroid had no significant effect on the result of SPT with allergens. In conclusion, it is suggested that theophyl- line, oral Salbutamol, and Prdnisolone have no significant effect on the result of skin prick  test with histamine, codeine and allergens.

5원저: 알레르기성 기관지천식 환자의 비점막과민성

저자 : 손지웅 , 이상록 , 김우경 , 김윤근 , 지영구 , 이명현 , 조상헌 , 민경업 , 고영률 , 김유영

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 502-510 (9 pages)

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Backgroued: The relationship between allergic rhinitis and bronchial asthma is controversial although it is well known that one is often accompanied by the other. Some considers these two as pathophysiologically the same, differing only in target organs. Bronchial hyperreactivity of asthma patients has been well documented, but whether they also have nasal hyperreactivity is unknown. Therefore we performed this study to evaluate the nasal reactivity of the patients with  allergic bronchial asthma. Method: 8 patients with allergic bronchial asthma who had no nasal symptoms were tested. 7 patients with allergic rhinitis and 5 healthy normal volunteers were also tested as positive and negative control respectively. To evaluate nasal reactivity, we challenged nasal mucosa with histamine and specific allergen. Before and during challenge, we recorded symptom score and nasal airway resistance by anterior rhinomanometric measurement. Results '. 1. 7 out of 8 asthmatic subjects had negative response and one weakly positive response. None of normal volunteers and all rhinitic patients showed positive response. 2. Mean logarithmic concentration of PCSS4  Histamine(concentration of hista- mine that provokes symptom scores of 4 out of total 6 points) of asthmatic, rhinitic, and normal subjects were 1.89+-0.22, 1.88+-0.16, and 0.75 +- 0.40mg/dl, respectively(Mean +- SE). There was no difference in nasal reactivity between asthmatics and normal subjects although patients with allergic rhinitis showed markedly increased reactivity compared to the other groups. 3. In specific allergen challenge test, all asthmatics showed negative responses. Conclusions . There was no difference in nasal reactivity between normal subjects and the patients with allergic bronchial asthma who had no nasal symptoms.

6원저: 기침형 천식 환자에서의 capsaicin 유발 기침반사의 감수성에 관한 연구

저자 : 지영구 , 김우경 , 김윤근 , 송숙희 , 조상헌 , 민경업 , 김유영

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 511-519 (9 pages)

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Cough, one of the most common respiratory symptoms, is the sole clinical manifestation in cough variant asthma. But the reason why cough develops in cough-variant asthma without showing dyspnea or wheezing is still unknown. Therefore capsaicin, tachykinin related reproducible tussive agent, was used to measure the cough sensitivity in the cough variant asthmatics, t,he classic asthmatics, and the normal control group. Cough sensitivity to capsaicin in the cough variant asthmatics increased significantly as compared to the control group and the classic asthmatics, but there were no differences between the control group and the classic asthmatics. Cough sensitivity to capsaicin showed no signif icant correlation with nonspecific airway hyperresponsiveness measured by methacholine. And correlation between cough sensitivity to capsaicin and base- line PFT was not significant. These results suggest that the cough in cough-variant asthma is related to the increased cough sensitivity to capsaicin and the mechanism of the capsaicin-induced cough is different from that of the nonspecific airway responsiveness t,o methacholine. There may be a role of tachykinin, such as substance P or neurokinin A, to cause cough in cough variant ast.hma.

7원저: 부비동염이 천식 환아의 기도과민성에 미치는 영향

저자 : 송광복 , 심정연 , 홍수종

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 520-525 (6 pages)

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Sinusitis is a common problem in children with bronchial asthma. The sinusitis may exacerbate asthma, but the causal relationship between sinusitis and asthma remains controversial. The aim of this study is to evaluate the influence of sinusitis on bronchial responsiveness in asthmatic children. Bronchial provocation test with methacholine were performed in the ast,hmatics with sinusitis before and after t,reatment of sinusitis and the concoulratins of methecholine causing a 20% fall in forced expiratory volume one second(PC) were determined. The PC was increased significantly in asthmatics with sinusitis after treat,ment of sinusitis. These data suggest that sinusitis may increase the bronchial responsiveness of asthmatics and treatment of sinusitis may be important in the control of asthma.

8원저: Toluene diisocyanate(TDI)에 의한 직업성 천식에서의 면역복합체의 역할

저자 : 서창희 , 남동호 , 박해심

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 526-536 (11 pages)

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Tolune diisocynate(TDI) is the most com- mon cause of occupational asthma in Korea as well as other industrialized countries. The pathogenetic mechanism of TDI-induced occu- pational asthma is still unclear. Immunological mechnism, such as IgE-medicated type I hypersensitivity, was thought to be involved in some TDI asthma patients. Other immulogical and non-immunological mechanisms have been suggested. To evaluate a possible role of circulating immune complex(CIC) in the development of TDI asthma, we measured C3- containing CIC in 21 TDI-induced asthmatics, which were confirmed by TDI-bronchoprovocation test, and they were compared with those of14 atopic asthma patients and 26 controls with no exposure history to TDI. Serum specific IgE antibodies to TDI-human serum albumin (HAS) conjugate were detected by RAST technique. The mean level of C3 contsining IgG-CIC tended to be higher in TDI asthma patients than those of atopic asthma and controls with no statistical significance(p=0.42). The IgG- CIC level correlated well with the percent fall of FEV, during the TDI brochoprovocation test(r=0.69, p=0.005), but poorly correlated with methacholine PC20. TDI asthma patients with high TDI-specific IgE antibody showed higher IgG-CIC level than those without specific IgE antibody(p=0.018). These data suggest that C3 containing IgG- CICs have a possible role in induction of inflammatory responses in TDI-induced occupational asthma.

9원저: 곡물분진에 의한 직업성 천식 : 특이 항체 및 호염기구 유리능

저자 : 박해심 , 남동호 , 서창희 , 권오영 , 조상헌 , 김유영

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 537-547 (11 pages)

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Grain dust-induced occupational asthma is commonly found in western countries. To the best of our knowledge, these are the first cases of grain dust-induced occupational asthma in this country. Their pathogenetic mechanisms still remains to be defined. Here we report six cases of occupational asthma induced by grain dust which was confirmed by bronchoprovocation test with grain dust extracts derived from their workplace. In order to further understand pathogenetic mechsnisms of grain dust-induced occupational asthma, we detected serum specific IgE, IgG and IgG antibodies to grain dust, and studied the direct activation of grain dust on basophils from them. Bronchoprovocstioan test showed tat early asthmatic response was the most commonly found one(5 patients) and dual asthmatic  response was noted in one patient. The PC20 methacholine ranged from 2.5 to 40mg/ml. High specific IgE antibodies to grain dust were detected in three(50%) patients. All had high specific IgG antibodies and all but one had high specific IgG, antibody. Basophil histamine release test revealed that grain dust extracts directly released significant amounts of histamirle from basophils as well as IgE- mediated rneohanisms. Minimal amounts of histamine release by anti-IgG antibodies was noted. These results suggested that grain dust can induce IgE-mediated bronchoconstrictions in exposed workers and grain dust may contain some potent active substances that can activate basophil.

10증례: 가족성 한랭 두드러기 1례

저자 : 이지호 , 박영민 , 김태윤 , 김형옥 , 김정원

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 548-552 (5 pages)

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Familial cold urticaria is a rare abnormal cutaneous and systemic reaction to cold with autosomal dominant inheritance, distinctive clinical features, and unknown etiology. A 21  year  old male patient presented with generalized erythematous macules and papules accompanied by burning, chills and arthralgia after cold exposure since early childhood. Autosomsl dominant inheritance was revealed on the examination of his pedigree. Autosomal dominant inheritance was revealed on the examination of his pedigree. Cold room challenge induced the same lesions after a delay of 20 min. Histopathologic findings showed a perivascular polymorphonuclear leukocytic infiltrstion with some eosinophils. He was treated with several antihistamines, but unsatisfaetory. We report a patient with a familial cold urticaris showing typical cutaneous manifests- tions and general symptoms with a consistent familial history through his five generations.

12
주제별 간행물
간행물명 수록권호

KCI등재 SCI SCOUPUS

Endocrinology and Metabolism(구 대한내분비학회지)
35권 4호 ~ 35권 4호

KCI등재 SCOUPUS

Tuberculosis and Respiratory Diseases
83권 0호 ~ 83권 0호

당뇨병(JKD)
21권 4호 ~ 21권 4호

KCI등재 SCI SCOUPUS

Diabetes and Metabolism Journal (DMJ)
44권 6호 ~ 44권 6호

KCI등재 SCI

The Korean Journal of Internal Medicine
36권 1호 ~ 36권 1호

KCI등재 SCOUPUS

Kidney Research and Clinical Practice(구 대한신장학회지)
39권 4호 ~ 39권 4호

KCI등재 SCOUPUS

대한소화기학회지
76권 6호 ~ 76권 6호

KCI등재 SCOUPUS

Tuberculosis and Respiratory Diseases
84권 1호 ~ 84권 1호

대한결핵및호흡기학회 추계학술발표초록집
128권 0호 ~ 128권 0호

KCI등재

International Journal of Thyroidology
13권 2호 ~ 13권 2호

KCI등재 SCOUPUS

Clinical Endoscopy
53권 6호 ~ 53권 6호

KCI등재 SCI

Gut and Liver
14권 6호 ~ 14권 6호

KCI등재 SCI

Gut and Liver
14권 6호 ~ 14권 6호

Korean Journal of Medicine(구 대한내과학회지)
95권 6호 ~ 95권 6호

KCI등재 SCI

Gut and Liver
14권 6호 ~ 14권 6호

KCI등재 SCI

Gut and Liver
14권 6호 ~ 14권 6호

대한내과학회 추계학술발표논문집
2020권 1호 ~ 2020권 2호

KCI등재 SCOUPUS

대한소화기학회지
76권 5호 ~ 76권 5호

KCI등재

Allergy asthma & respiratory disease
8권 4호 ~ 8권 4호

KCI등재 SCOUPUS

Intestinal research (Intest Res)
18권 4호 ~ 18권 4호
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