Introduction: Colorectal cancer is common and the liver and lung are frequent metastatic sites. But single metastasis from colorectal cancer to the central airway is rare. In a fatal central airway obstruction, surgical procedures under general anesthesia were the preferred management. However in patients who are not candidates for surgical procedures, bronchoscopic approaches offered a safe and effective alternative in the palliative management of respiratory symptoms. Argon plasma coagulation (APC) is a valuable tool in treating bleeding and debulking granulation tissue and tumors. In addition cryotherapy relies on repeated cycles for tissue destruction, and spares cartilaginous structures. Case report: A 78-years-old woman was consulted to our department because of solitary endobronchial metastasis of previous colon cancer through rigid bronchoscopic biopsy. 6 years ago, she was underwent laparoscopic anterior resection due to sigmoid colon cancer. After that, she was diagnosed solitary liver and lung metastasis, so she was followed by segmentectomy and adjuvant chemotherapy. She presented severe dyspnea and Physical examination revealed severe wheezing sounds on both lung fields. Chest computed tomography (CT) scan showed about 1.5cm sized protruding mass on carina level of distal trachea. Similarly fiexible bronchoscopy revealed a polypoid mass on peri-carina region. She underwent mechanical debulking procedures using biopsy forcep after Cryotherapy and marginal APC under deep sedation with profopol, fentanyl, & bolus midazolam. After procedures, carina mass was nearly removed and both main bronchi patency were saved After that, sympoms and brochoscopic findings was improved gradually and specific complication was not observed Conclusion: We report an interesting case of the successful debukling management with combined APC and cryotherapy guided by fiexible bronchoscopy under the simple sedation in a patient with near total airway obstruction from colorectal cancer.