간행물

혜화의학회지 update

Journal of Haehwa Medicine

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수록정보
수록범위 : 1권1호(1992)~29권1호(2020) |수록논문 수 : 1,083
혜화의학회지
29권1호(2020년 03월) 수록논문
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1비만 생쥐모델의 폐약(肺弱)을 유발하기 위한 Bleomycin의 농도 결정 연구

저자 : 고영미 ( Young-mee Koh ) , 장순우 ( Soon-woo Jang ) , 안택원 ( Taek-won Ahn )

발행기관 : 대전대학교 한의학연구소 간행물 : 혜화의학회지 29권 1호 발행 연도 : 2020 페이지 : pp. 1-17 (17 pages)

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Objectives : The objectives of this study is to develop a mouse model similar to Taeeum-type by inducing Lung fibrosis with bleomycin, and to determine adequate concentration of bleomycin. Methods : The subjects were divided into six groups: normal, obesity induced group, and bleomycin administered 0.015U, 0.03U, 0.06U, and 0.09U(U/100g bw) concentrations respectively. Each concentration of bleomycin was dissolved in distilled water, and administered through Intra-Nazal-Trachea injection method. Food intake and body weight were measured at regular time weekly. At the end of the experiment, blood was gathered by cardiac puncture for biochemical examinations, organs were removed for histological examinations, and weigh and mRNA genes was analyzed. Result : Mice administered with bleomycin at 0.015U and 0.03U showed body and fat weight gain, and increased blood total cholesterol, LDL-cholesterol, glucose, and free fatty acid level. Fat related genes also showed higher level than the control group. Obesity was most strongly induced in the mice administered with 0.03U of bleomycin. On the other hand, when bleomycin was administered at concentrations above 0.06U, a model of obesity mouse was not created due to rapid emphysema inflammation and weakness. Conclusions : Mice were most vulnerable to obesity when bleomycin was administered at a concentration of 0.3 to cause liver damage. Bleomycin concentration over 0.06U did not cause obesity-induced mice, due to severe damage in liver.

2좌골신경 손상 후 스트렙토조토신 유도성 당뇨병에 의한 축사재생의 지연 효과

저자 : 황진연 ( Jinyeon Hwang ) , 김기중 ( Ki-joong Kim ) , 남궁욱 ( Uk Namgung )

발행기관 : 대전대학교 한의학연구소 간행물 : 혜화의학회지 29권 1호 발행 연도 : 2020 페이지 : pp. 18-25 (8 pages)

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Objective: The goal of this study is to investigate whether peripheral axonal regeneration is affected by diabetes in experimental animals. Method: Sprague Dawely rat was injected with 45~50 mg/kg of streptozotocin (STZ) to generate an animal model of diabetes. Three months after STZ injection, sciatic nerve (2 cm length) was removed and the same length of nerve segments from STZ-injected animal or from control animal (CTL) was transplanted into STZ - injected animals (STZ - STZ and STZ - CTL respectively). Similarly, sciatic nerve segments from STZ - injected animal or from control animal were grafted into the control animals (CTL - STZ and CTL - CTL respectively). All animals were sacrificed 2 weeks after transplantation. Sciatic nerve sections were prepared and subjected to immunofluorescence staining analysis. Results: Immunofluorescence staining for NF - 200 showed that distal elongation of regenerating axons reached 40~80% of proximal neve in both CTL - STZ and CTL - CTL groups. However, distal elongation in both STZ - STZ and STZ - CTL groups were 20~60% of proximal nerve. Furthermore, measurement of axonal regeneration after immuno - staining with SCG10 showed that the scores of distal elongation relative to proximal nerve were 50~90% in CTL - CTL and CTL - STZ groups and 10 - 60% in STZ - CTL and STZ - STZ. Conclusions: Our data showed that the levels of axonal regeneration were not affected irrespective of whether they were from STZ- or CTL graft, but were greatly reduced when the nerves were transplanted into the STZ host.

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1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

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경희대학교 대전대학교 원광대학교 대구한의대학교(구 경산대학교) 한국방송통신대학교
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