간행물

한국생약학회> Natural Product Sciences

Natural Product Sciences update

  • : 한국생약학회
  • : 의약학분야  >  약화학
  • : KCI등재
  • : SCOPUS
  • : 연속간행물
  • : 계간
  • : 1226-3907
  • :
  • :

수록정보
수록범위 : 1권1호(1995)~24권2호(2018) |수록논문 수 : 1,037
Natural Product Sciences
24권2호(2018년 06월) 수록논문
최근 권호 논문
| | | |

KCI등재 SCOPUS

1A Bioactive Depsidone from Lachnum virgineum (Hyaloscyphaceae)

저자 : Yoshihito Shiono , Takuya Koseki , Hiromasa Koyama

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 2호 발행 연도 : 2018 페이지 : pp. 79-81 (3 pages)

다운로드

(기관인증 필요)

초록보기

Norcolensoic acid (1) was isolated from both the fruiting bodies and the liquid culture of Lachnum virgineum. The structures of 1 was determined using spectroscopic methods. Compound 1 was isolated for the first time from this fungus. Compound 1 showed moderate antibacterial and phytotoxic activities.

KCI등재 SCOPUS

2Determination of Silybin B in the Different Parts of Silybum marianum using HPLC-UV

저자 : Joyce P. Rodriguez , Norman G. Quilantang , Ju Sung Lee , Jeong Mi

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 2호 발행 연도 : 2018 페이지 : pp. 82-87 (6 pages)

다운로드

(기관인증 필요)

초록보기

Silymarin is the standardized extract from Silybum marianum which consists mainly of flavonoids and polyphenols. It is highly regarded for its hepatoprotective ability. Silybin B is a flavonolignan and one of the active components of silymarin. The content of silybin B in various parts of S. marianum was analyzed by HPLC-UV. Results show that the extract of seeds contain the highest amount of silybin B (7.434 mg/g DW). The petioles of S. marianum showed a low content of silybin B. This study revealed that seeds of S. marianum contain high amount of silybin B and could be a good source of the compound.

KCI등재 SCOPUS

3Garcinexanthone G, a Selective Butyrylcholinesterase Inhibitor from the Stem Bark of Garcinia atroviridis

저자 : Kooi-yeong Khaw , Vikneswaran Murugaiyah , Melati Khairuddean , We

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 2호 발행 연도 : 2018 페이지 : pp. 88-92 (5 pages)

다운로드

(기관인증 필요)

초록보기

The present study was undertaken to investigate the isolated compounds from the stem bark of Garcinia atroviridis as potential cholinesterase inhibitors and the ligand-enzyme interactions of selected bioactive compounds in silico. The in vitro cholinesterase results showed that quercetin (3) was the most active AChE inhibitor (12.65 ± 1.57 μg/ml) while garcinexanthone G (6) was the most active BChE inhibitor (18.86 ± 2.41 μg/ml). It is noteworthy to note that compound 6 was a selective inhibitor with the selectivity index of 11.82. Molecular insight from docking interaction further substantiate that orientation of compound 6 in the catalytic site which enhanced its binding affinity as compared to other xanthones. The nature of protein-ligand interactions of compound 6 is mainly hydrogen bonding, and the hydroxyl group of compound 6 at C-10 is vital in BChE inhibition activity. Therefore, compound 6 is a notable lead for further drug design and development of BChE selective inhibitor.

KCI등재 SCOPUS

4Cytotoxic Triterpenoids from the Fruits of Ligustrum japonicum

저자 : Quynh-mai Thi Ngo , Thao Quyen Cao , Mi Hee Woo , Byung Sun Min

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 2호 발행 연도 : 2018 페이지 : pp. 93-98 (6 pages)

다운로드

(기관인증 필요)

초록보기

Medicinal plants are potential sources of anticancer agents screening. A large number of phytochemicals, including triterpenoids, have been reported to have significant cytotoxic effects on cancer cells. From the fruits of Ligustrum japonicum Thunb., thirteen triterpenoids (1 - 13) were isolated and evaluated for their cytotoxic activity against Hela and HL-60 cells. As results, 8 (oleanolic acid) showed significant effects on Hela with IC50 values of 5.5 μM, and moderate effects on HL-60 cells with IC50 values of 55.9 μM. Meanwhile, 10 (oleanderic acid) and 11 (3β-acetoxy-urs-12-en-28-oic acid) exhibited moderate inhibitory effects on Hela with IC50 value of 55.0 and 68.8 μM, respectively. Moreover, 10 showed cytotoxic effect on HL-60 cell line with IC50 value of 63.9 μM. To our knowledge, this is the first report that oleanderic acid was isolated from L. japonicum and investigated in cytotoxic effects on Hela and HL-60 cells.

KCI등재 SCOPUS

5Ameliorative Effects of Ombuoside on Dopamine Biosynthesis in PC12 Cells

저자 : Uchralsaikhan Davaasambuu , Keun Hong Park , Hyun Jin Park , Hyun

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 2호 발행 연도 : 2018 페이지 : pp. 99-102 (4 pages)

다운로드

(기관인증 필요)

초록보기

This study investigated the effects of ombuoside, a flavonol glycoside, on dopamine biosynthesis in PC12 cells. Ombuoside at concentrations of 1, 5, and 10 μM increased intracellular dopamine levels at 1 - 24 h. Ombuoside (1, 5, and 10 μM) also significantly increased the phosphorylation of tyrosine hydroxylase (TH) (Ser40) and cyclic AMP-response element binding protein (CREB) (Ser133) at 0.5 - 6 h. In addition, ombuoside (1, 5, and 10 μM) combined with L-DOPA (20, 100, and 200 μM) further increased intracellular dopamine levels for 24 h compared to L-DOPA alone. These results suggest that ombuoside regulates dopamine biosynthesis by modulating TH and CREB activation in PC12 cells.

KCI등재 SCOPUS

6Optimization of Extraction Condition of Methyl Jasmonate-treated Wild Ginseng Adventitious Root Cultures using Response Surface Methodology

저자 : Qing Liu , Yang Hee Jo , Jong Hoon Ahn , Seon Beom Kim , Kee-y

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 2호 발행 연도 : 2018 페이지 : pp. 103-108 (6 pages)

다운로드

(기관인증 필요)

초록보기

The usage of wild ginseng (Panax ginseng C.A. Meyer) has been limited due to short supply and high price. Therefore, sufficient production as well as efficient extraction of mountain ginseng are required for the development as products. In this study, wild ginseng adventitious root cultures were prepared for efficient production with advantages of fast growth and stable production. Treatment of methyl jasmonate (MJ) to wild ginseng adventitious root cultures increased the extraction yield and antioxidative activity. Further investigation on effect of extraction conditions suggested the importance of ethanol concentration on antioxidative activity and extraction yield of MJ-treated wild ginseng adventitious root cultures. Optimized extraction condition of MJtreated wild ginseng adventitious root cultures for maximum extraction yield and antioxidative activity was determined using response surface methodology with three-level-three-factor Box-Behnken design (BBD). Extraction of 1 g MJ-treated wild ginseng adventitious root culture with 30 ml of 9% ethanol at 30 ℃ produced 310.2 mg extract with 71.0% antioxidative activity at 100 μg/ml. Taken together, MJ-treated wild ginseng adventitious root culture is valuable source for wild ginseng usage and optimized extraction condition can be used for the development of functional products or folk remedies.

KCI등재 SCOPUS

7Simultaneous Determination of Four Compounds from Artemisia capillaris using High Performance Liquid Chromatography-Ultraviolet Detector (HPLC-UVD) and Their Quantitative Study in Artemisia Genus

저자 : Kiwon Ko , In Kee Hong , Hyun-jong Cho , Young Ho Kim , Heejun

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 2호 발행 연도 : 2018 페이지 : pp. 109-114 (6 pages)

다운로드

(기관인증 필요)

초록보기

Artemisia capillaris Thunb. (Compositae) is a native herb of East Asian countries and has used for the treatment of jaundice, high liver fever, and digestive diseases for a long time, as well as being developed as the source of herbal preparations until now. The major components from A. capillaris were chlorogenic acid (1) and its derivatives substituted with caffeoyl moieties, such as 3,5-dicaffeoylquinic acid (2) and 4,5-dicaffeoylquinic acid (3), and coumarins, such as scoparone. In the study, four compounds, chlorogenic acid, 3,5-dicaffeoylquinic acid, 4,5-dicaffeoylquinic acid and scoparone (4) in the 70% ethanolic extract of A. capillaris were simultaneously determined by using HPLC-UVD system. This method was validated with the terms of linearity, precious and accuracy according to ICH guidelines. The developed method was successfully applied for the quantitative analysis of Artemisia genus, A. capillaris, A. iwayomogi, A. princeps, and A. argyi, distributed in Korea.

KCI등재 SCOPUS

8Ethyl Haematommate from Stereocaulon graminosum Schaer.: Isolation and Crystal Structure

저자 : Friardi Ismed , Nurwahidatul Arifa , Erizal Zaini , Amri Bakhtiar

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 2호 발행 연도 : 2018 페이지 : pp. 115-118 (4 pages)

다운로드

(기관인증 필요)

초록보기

Herein, we reported the phytochemical investigation of whole thallus Sumatran lichen, Stereocaulon graminosum Schaer, and isolated a mono aromatic compound, ethyl haematommate (1). The structure of compound 1 have been established based on spectroscopic data and confirmed by single crystal X-ray structure analysis.

KCI등재 SCOPUS

9Antioxidant Compounds Isolated from the Roots of Phlomis umbrosa Turcz.

저자 : Duc Hung Nguyen , Duc Dat Le , Bing Tian Zhao , Eun Sook Ma ,

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 2호 발행 연도 : 2018 페이지 : pp. 119-124 (6 pages)

다운로드

(기관인증 필요)

초록보기

Two triterpenoids, arjunolic acid (1), belleric acid (2), five phenylethanoids, martynoside (3), orobanchoside (4), 3,4-dihydroxyphenethylalcohol-6-O-caffeoyl-β-D-glucoside (5), leucosceptoside B (6), lunariifolioside (7), four phenolic acids, ferulic acid (8), syringic acid (9), vanillic acid (10), 4-hydroxybenzoic acid (11), and one lignan, (+)-syringaresinol-β-D-glucoside (12), were isolated from the roots of P. umbrosa. All isolated compounds were explored for their antioxidant potential in the DPPH and ABTS assays. In DPPH assay, compound 5 showed high antioxidant capacity. Compounds 3, 4, 6, and 7 displayed considerable antioxidant activities. In addition, compounds 5-7 exhibited potential antioxidant capacities in the ABTS assay.

KCI등재 SCOPUS

10Chemical Composition and Antioxidant Activity of Algerian Juniperus Phoenicea Essential Oil

저자 : Aicha Harhour , Moussa Brada , Marie-laure Fauconnier , Georges Lo

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 2호 발행 연도 : 2018 페이지 : pp. 125-131 (7 pages)

다운로드

(기관인증 필요)

초록보기

Berries and branches essential oil of Juniperus phoenicea were obtained by electromagnetic induction heating assisted extraction and by hydrodistillation with a yield varied from (1.2 ± 0.3 to 2.4 ± 0.7%) and from (0.6 ± 0.1% to 1.1 ± 0.1%), respectively. forty eight compounds were identified representing (97.2 - 99.7%) of the oil. α-Pinene (40.3 - 67.8%) and δ-3-carene (13.5 - 26.8%) were the main compounds in berries and branches essential oils. Antioxidant activity was evaluated by three means: inhibition of 2, 2-diphenyl-1-picryl hydrazyl (DPPH) free radical, reducing power and β-Carotene/linoleic acid bleaching. The antioxidant activity of essential oils showed IC50 ranging from 67.6 ± 1.02 μg/mL to 131.5 ± 0.8 μg/mL for berries and from 98 ± 1.25 μg/mL to 166.8 ± 0.29 μg/mL for the branches. Berries oil show more potent antioxidant activity compared to branches. This result is supported by the three methods investigated in this work.

12
권호별 보기
가장 많이 인용된 논문

(자료제공: 네이버학술정보)

가장 많이 인용된 논문
| | | |
1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

다운로드

2미국의 비트코인 규제

(2006)홍길동심리학41회 피인용

다운로드

가장 많이 참고한 논문

(자료제공: 네이버학술정보)

가장 많이 참고한 논문

다운로드

2미국의 비트코인 규제

(2006)홍길동41회 피인용

다운로드

해당 간행물 관심 구독기관

서울대학교 가천대학교 서원대학교 경희대학교 안동대학교
 3
 3
 3
 2
 2
  • 1 서울대학교 (3건)
  • 2 가천대학교 (3건)
  • 3 서원대학교 (3건)
  • 4 경희대학교 (2건)
  • 5 안동대학교 (2건)
  • 6 농촌진흥청 (2건)
  • 7 중앙대학교(안성) (2건)
  • 8 경남과학기술대학교 (2건)
  • 9 Monash University (2건)
  • 10 한양대학교 (2건)

내가 찾은 최근 검색어

최근 열람 자료

맞춤 논문

보관함

내 보관함
공유한 보관함

1:1문의

닫기