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수록정보
수록범위 : 1권1호(1995)~24권4호(2018) |수록논문 수 : 1,062
Natural Product Sciences
24권4호(2018년) 수록논문
최근 권호 논문
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KCI등재 SCOPUS

1The Cytotoxic Constituents of Betula platyphylla and their Effects on Human Lung A549 Cancer Cells

저자 : Eun-ju Yang , Ju-hee An , Youn Kyoung Son , Joo-hong Yeo , Kyung-sik Song

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 4호 발행 연도 : 2018 페이지 : pp. 219-224 (6 pages)

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During the screening for cytotoxic compounds from plants grown in Korea, Betula platyphylla (BP) showed potent activity against the adenocarcinomic human alveolar basal epithelial A549 cell line. To identify the cytotoxic components from BP, the CH2Cl2 fraction with the most significant cytotoxic effect was applied to the column chromatographies. Seven compounds were isolated: lupeol (1), betulinic acid (2), (-)-rhododendrol (3), platyphyllenone (4), platyphyllone (5), (-)-centrolobol (6), and oleanolic acid (7). Among them, three diarylheptanoids (4 - 6) exhibited cytotoxicity toward A549 cells. Especially, 50 μM of 4 reduced A549 cell viability to 18.93 ± 0.82% compared to control (100.00 ± 21.48%). Lactate dehydrogenase (LDH) leakage and intracellular reactive oxygen species (ROS) production were also induced by 50 μM 4. This is the first report on the cytotoxic effect of BP-derived diarylheptanoids 4-6 against A549 cells. The compound 4 may be useful for the development of early hit compounds for non-small cell lung carcinoma, but the consideration about selectivity of 4 is required since 4 also showed the cytotoxicity in the human normal lung epithelial BEAS-2B cell line.

KCI등재 SCOPUS

2Gliotoxin is Antibacterial to Drug-resistant Piscine Pathogens

저자 : Haoran Feng , Sen Liu , Mingzhi Su , Eun La Kim , Jongki Hong , Jee H. Jung

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 4호 발행 연도 : 2018 페이지 : pp. 225-228 (4 pages)

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By activity-guided fractionation, gliotoxin was isolated as an antibacterial metabolite of the fungus Penicillium decumbens which was derived from the jellyfish Nemopilema nomurai. Gliotoxin was further evaluated for antibacterial activity against several piscine and human MDR (multidrug resistance) pathogens. Gliotoxin showed significant antibacterial activity against Gram-positive piscine pathogens such as Streptococcus iniae FP5228, Streptococcus iniae FP3187, Streptococcus parauberis FP3287, Streptococcus parauberis SPOF3K, S. parauberis KSP28, and Lactococcus garvieae FP5245. Gliotoxin showed strong activity especially against S. parauberis SPOF3K and S. iniae FP5228, which are resistant to oxytetracycline. It is noteworthy that gliotoxin effectively suppressed streptococci which are the major pathogens for piscine infection and mortality in aquaculture industry. Gliotoxin also showed strong antibacterial activity against multidrug- resistant human pathogens (MDR) including Enterococcus faecium 5270 and MRSA (methicillin-resistant Staphylococcus aureus) 3089.

KCI등재 SCOPUS

3Quantitative Analysis of Dammarane-type Ginsenosides in Different Ginseng Products

저자 : Dong Gu Lee , Norman G. Quilantang , Ju Sung Lee , Paul John L. Geraldino , Hyun Young Kim , Sanghyun Lee

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 4호 발행 연도 : 2018 페이지 : pp. 229-234 (6 pages)

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Ginseng products available in different forms and preparations are reported to have varied bioactivities and chemical compositions. In our previous study, four new dammarane-type ginsenosides were isolated from Panax ginseng, which are ginsenoside Rg18 (1), 6-acetyl ginsenoside Rg3 (2), ginsenoside Rs11 (3), and ginsenoside Re7 (4). Accordingly, the goal of this study was to determine the distribution and content of these newly characterized ginsenosides in different ginseng products. The content of compounds 1 - 4 in different ginseng products was determined via HPLC-UV. The samples included ginseng roots from different ginseng species, roots harvested from different localities in Korea, and samples harvested at different cultivation ages and processed under different manufacturing methods. The four ginsenosides were present at varying concentrations in the different ginseng samples examined. The variations in their content could be attributed to species variation, and differences in cultivation conditions and manufacturing methods. The total concentration of compounds 1 - 4 were highest in ginseng obtained from Geumsan (185 μg/g), white-6 yr ginseng (150 μg/g), and P. quinquefolius (186 μg/g). The results of this study provide a basis for the optimization of cultivation conditions and manufacturing methods to maximize the yield of the four new ginsenosides in ginseng.

KCI등재 SCOPUS

4LC/MS-based Analysis of Bioactive Compounds from the Bark of Betula platyphylla var. japonica and Their Effects on Regulation of Adipocyte and Osteoblast Differentiation

저자 : Su Cheol Baek , Eunyong Choi , Hee Jeong Eom , Mun Seok Jo , Sil Kim , Hae Min So , Seon-hee Kim , Ki Sung Kang , Ki Hyun Kim

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 4호 발행 연도 : 2018 페이지 : pp. 235-240 (6 pages)

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Betula platyphylla var. japonica (Betulaceae), also known as Asian white birch, is an endemic medicinal tree, the bark of which has been used in Chinese traditional medicine for the treatment of various inflammatory diseases. In our continuing search for bioactive compounds from Korean natural resources, a phytochemical investigation of the bark of B. platyphylla var. japonica led to the isolation of 7-oxo-β-sitosterol (1) and soyacerebroside I (2) from its ethanol extract as main components by liquid chromatography (LC)/mass spectrometry (MS)-based analysis. The structures of isolates were identified by comparison of 1H and 13C nuclear magnetic resonance spectroscopic data and physical data with the previously reported values and LC/MS analyses. To the best of our knowledge, this is the first study to demonstrate that the isolated compounds, 7-oxo-β- sitosterol and soyacerebroside I, were isolated in B. platyphylla var. japonica. We examined the effects of the isolates on the regulation of adipocytes and osteoblast differentiation. These isolates (1 and 2) produced fewer lipid droplets compared to the untreated negative control in Oil Red O staining of the mouse mesenchymal stem cell line without altering the amount of alkaline phosphatase staining. The results demonstrated that both compounds showed marginal inhibitory effects on adipocyte differentiation but did not affect osteoblast differentiation.

KCI등재 SCOPUS

5Identification and HPLC Quantification of a Phytoecdysone and Three Phenolic Glycosides in Lamium takesimense Nakai

저자 : Agung Nugroho , Kyoung-sik Park , Dong-jin Seo , Hee-juhn Park

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 4호 발행 연도 : 2018 페이지 : pp. 241-246 (6 pages)

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The herbs of Lamium takesimense Nakai (Lamiaceae) is used to treat spasmodic and inflammatory disease. The four polar compounds, ecdysterone, isoacteoside, rutin and lamiuside C, were isolated and identified from the BuOH fraction of the L. takesimense MeOH extract. HPLC quantification was performed on a Capcell Pak C18 column (5 μm, 4.6 mm × 250 mm) with a gradient elution of H2O and 0.05% acetic acid in MeOH. The HPLC method was validated in terms of linearity, sensitivity, stability, precision, and accuracy. The quantitative level in plant material was determined as the following order: lamiuside C (4, 3.75 mg/g dry weight) > ecdysterone (1, 1.93 mg/g) > isoacteoside (2, 1.32 mg/g) > rutin (3, 0.97 mg/g).

KCI등재 SCOPUS

6Comparison of Biological Activities of Korean Halophytes

저자 : Jeong Min Lee , Mi-jin Yim , Dae-sung Lee , Myeong Seok Lee , Yun Gyeong Park , Jae Hyuk Jeon , Grace Choi

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 4호 발행 연도 : 2018 페이지 : pp. 247-252 (6 pages)

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Halophytes are expected to possess abundant secondary metabolites and various biological activities because of habitat in extreme environments. In this study, we collected 14 halophytes (Asparagus oligoclonos, Calystegia soldanella, Carex pumila, Chenopodium glaucum, Elymus mollis, Glehnia littoralis, Limonium tetragonum, Messerschmidia sibirica, Rosa rugosa, Salsola komarovii, Spergularia marina, Suaeda glauca, Suaeda maritima, and Vitex rotundifolia) native to Korea and compared their total polyphenol contents, antioxidant and anti-inflammatory activities. The total polyphenol contents of R. rugosa (27.28%) and L. tetragonum (13.17%) were significantly higher than those of the other 12 halophytes and L. tetragonum, R. rugosa, and M. sibirica showed significantly greater antioxidant activities than the other 11 halophytes, as determined by DPPH (2,2-diphenyl-1-picrylhydrazyl). A. oligoclonos, E. mollis, and C. pumila showed significantly greater anti-inflammatory activities than the other 11, as determined by NO (Nitric oxide) and PGE2 (Prostaglandin E2) levels. In contrast, these three extracts had normal and low total polyphenol contents among the 14 halophytes. Consequently, the total polyphenol content in the 14 studied halophytes appeared to be related to antioxidant, but not anti-inflammatory activity levels.

KCI등재 SCOPUS

7New Meroterpenoids from a Penicillium sp. Fungus

저자 : Ji-yeon Hwang , Min Jung You , Dong-chan Oh , Ki-bong Oh , Jongheon Shin

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 4호 발행 연도 : 2018 페이지 : pp. 253-258 (6 pages)

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Two meroterpenoids (1 and 2) along with twelve known compounds (3 - 14) were isolated from the culture broth of a Penicillium sp. fungus collected from Chuja-do, Korea. Based on the results of a combination of spectroscopic analyses, the new compounds, preaustinoids E (1) and F (2), were determined to be epimeric austintype penta-cyclic lactones.

KCI등재 SCOPUS

8Isolation of Flavonoid Glycosides with Cholinesterase Inhibition Activity and Quantification from Stachys japonica

저자 : Agung Nugroho , Jae Sue Choi , Su Hui Seong , Byong-min Song , Kyoung-sik Park , Hee-juhn Park

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 4호 발행 연도 : 2018 페이지 : pp. 259-265 (7 pages)

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The three flavone glycosides, 4'-O-methylisoscutellarein 7-O-(6'''-O-acetyl)-β-D-allopyranosyl(1→2)- β-D-glucopyranoside (1), isoscutellarein 7-O-(6'''-O-acetyl)-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (3), and isoscutellarein 7-O-β-D-allopyranosyl(1→2)-β-D-glucopyranoside (4) in addition to a flavonol glycoside, kaempferol 3-O-β-D-glucopyranoside (astragalin, 2), were isolated from Stachys japonica (Lamiaceae). In cholinesterase inhibition assay, compound 1 significantly inhibited aceylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities (IC50s, 39.94 μg/ml for AChE and 86.98 μg/ml for BChE). The content of isolated compounds were evaluated in this plant extract by HPLC analysis. Our experimental results suggest that the flavonoid glycosides of S. japonica could prevent the memory impairment of Alzheimer's disease.

KCI등재 SCOPUS

9Five New Stilbenes from the Stem Bark of Artocarpus communis

저자 : Susanna T. S. Chan , Wendy L. Popplewell , Heidi R. Bokesch , Tawnya C. Mckee , Kirk R. Gustafson

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 4호 발행 연도 : 2018 페이지 : pp. 266-271 (6 pages)

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Five new prenylated stilbenes (1 - 5), along with the known compounds cudraflavone C, trans-4- isopentenyl-3,5,2',4'-terahydroxystilbene, trans-4-(3-methyl-E-but-1-enyl)-3,5,2',4'-tetrahydroxystilbene, pannokin G, cycloartobiloxanthone, artonin P, morusin, artocarpin, artonin E, kuwanon C, artobiloxanthone, and artoindonesianin C (6 - 17) were isolated from the stem bark of the tropical tree Artocarpus communis. The structures were established by NMR spectroscopic analysis, MS studies, and comparison with spectral data reported in the literature.

KCI등재 SCOPUS

10Nematicidal Compounds from the Leaves of Schinus terebinthifolius Against Root-knot Nematode, Meloidogyne incognita Infecting Tomato

저자 : Fatma M. Abdel Bar , Dina S. Ibrahim , Sahar R. Gedara , Mohammed S. Abdel-raziq , Ahmed M. Zaghloul

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 4호 발행 연도 : 2018 페이지 : pp. 272-283 (12 pages)

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The root-knot nematode, Meloidogyne incognita caused a serious damage to many plants. The phenolic components of the leaves of Schinus terebinthifolius were investigated as potential nematicidal agents for M. incognita. Nine compounds were isolated and characterized as viz., 1,2,3,4,6-pentagalloyl glucose (1), kaempferol-3-O-α-L-rhamnoside (Afzelin) (2), quercetin-3-O-α-L-rhamnoside (Quercetrin) (3), myricetin (4), myricetin-3-O-α-L-rhamnoside (Myricetrin) (5), methylgallate (6), protocatechuic acid (7), quercetin (8), and gallic acid (9) using nuclear magnetic resonance (NMR) spectroscopy. Compound 1 showed pronounced nematicidal activity compared to Oxamyl as a positive control. It showed the lowest eggs-hatchability (34%) and the highest mortality in nematode population (21% after 72 hours of treatment) at a concentration of 200 μg/mL. It exhibited the best suppressed total nematode population, root galling and number of eggmasses in infected tomato plants. The total carbohydrates and proteins were also significantly induced by 1 with reduction in total phenolics and increase in defense-related proteins. Thus, compound 1 could be a promising, more safe and effective natural nematicidal agent for the control of root-knot nematodes.

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Kyoto University 대구가톨릭대학교 경희대학교 강원대학교 부산대학교
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  • 1 Kyoto University (4건)
  • 2 대구가톨릭대학교 (4건)
  • 3 경희대학교 (4건)
  • 4 강원대학교 (2건)
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  • 6 한국한의학연구원 (2건)
  • 7 대구한의대학교(구 경산대학교) (2건)
  • 8 제주대학교 (2건)
  • 9 동의대학교 (2건)
  • 10 전주대학교 (1건)

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