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수록정보
수록범위 : 1권1호(1995)~24권3호(2018) |수록논문 수 : 1,049
Natural Product Sciences
24권3호(2018년 09월) 수록논문
최근 권호 논문
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KCI등재 SCOPUS

1Essential Oils: Biological Activity Beyond Aromatherapy

저자 : Shagufta Kar , Pawan Gupta , Jeena Gupta

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 3호 발행 연도 : 2018 페이지 : pp. 139-147 (9 pages)

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The essential oils are fragrant products whose complex compositions are obtained from various parts of plants by dry or steam distillation. Plants with variable biological activities have been explored worldwide. The presence of a large number of phenols, terpenes and other aromatic compounds make essential oils more precise in their mode of action. Because of this, they are known to possess many biological activities like antimicrobial, antioxidant and anti-inflammatory etc. In this article, we will review the published literature summarizing the chemistry of essential oils and their important biological activities.

KCI등재 SCOPUS

2Acer okamotoanum Inhibit the Hydrogen Peroxide-Induced Oxidative Stress in C6 Glial Cells

저자 : Soo Yeon Choi , Ji Hyun Kim , Norman G , Quilantang , Sanghyun Lee , Eun Ju Cho

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 3호 발행 연도 : 2018 페이지 : pp. 148-154 (7 pages)

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Chronic oxidative stress due to the accumulation of reactive oxygen species (ROS) in neuronal cells ultimately leads to neurodegenerative diseases. The use of natural therapies for the prevention of ROS-induced cell damage and for the treatment of neurodegenerative disorders has shown promising results. In this study, we evaluated the neuroprotective effects of the ethyl acetate (EtOAc) fraction of A. okamotoanum against the hydrogen peroxide (H2O2)-induced oxidative stress in C6 glial cells. Results show that cell viability was decreased in cells incubated with H2O2, whereas the addition of EtOAc fraction treatments in such cells significantly increased viability. The EtOAc fraction showed the highest inhibitory activity against ROS production and it also decreased the expressions of inflammatory proteins including cyclooxygenase-2, inducible nitric oxide synthase and interleukin-1β. Furthermore, the EtOAc fraction inhibited apoptosis by regulating the protein expressions cleaved caspase -9, -3, poly ADP ribose polymerase, Bax and Bcl-2. Therefore, these results show that the EtOAc fraction of A. Okamotoanum exhibits neuroprotective effects against H2O2 induced oxidative damage by regulating the inflammatory reaction and apoptotic pathway.

KCI등재 SCOPUS

3Meliglabrin, A New Flavonol Derivative from the leaves of Melicope glabra (Blume) T.G. Hartley

저자 : Ratih Dewi Saputri , Tjitjik Srie Tjahjandarie , Mulyadi Tanjung

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 3호 발행 연도 : 2018 페이지 : pp. 155-158 (4 pages)

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A new flavonol derivative, meliglabrin (1) along with three known flavonols, ternatin (2), meliternatin (3), and 5,4'-dihydroxy-3,7,3'-trimethoxyflavon (4) were isolated from the leaves of Melicope glabra (Blume) T.G. Hartley. Their structures were determined using extensive spectroscopic methods, including UV, IR, HRESIMS, 1D and 2D NMR. Compounds 1 - 4 were evaluated for their cytotoxicity against murine leukemia P- 388 cells, compound 4 showed moderate activity.

KCI등재 SCOPUS

4Chinoketides A and B, Two New Antimicrobial Polyketides from the Endophytes of Distylium chinense with the “Black-Box” Co-culture Method

저자 : Meng-meng Lv , Ming-hui Tan , Li-wen Lu , Rong-hua Zhang , Zhi-yong Guo , Cheng-xiong Liu , Jin Yang , Kun Zou , Peter Proksch

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 3호 발행 연도 : 2018 페이지 : pp. 159-163 (5 pages)

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Two new polyketides, chinoketides A and B (1 - 2) with a known compound xylarphthalide A (3), were isolated from the solid medium of the endophytes from the leaves of the relic plant Distylium chinense with the “black-box” co-culture method, and the structures of two new compounds were elucidated by NMR, MS and CD spectra. And the absolute configurations of chinoketides A (1) and B (2) were determined as 2R,3R,8S and 5R,6S by calculating their ECD spectra to compare with the experimental CD spectra. Finally, the antimicrobial activities were evaluated to Erwinia carotovora sub sp. Carotovora (Jones) Bersey et al, and the results showed that compounds 1 - 3 displayed the antimicrobial activities with MIC value at 20.5, 30.4 and 10.2 μg/mL.

KCI등재 SCOPUS

5Classficiation of Bupleuri Radix according to Geographical Origins using Near Infrared Spectroscopy (NIRS) Combined with Supervised Pattern Recognition

저자 : Dong Young Lee , Kyo Bin Kang , Jina Kim , Hyo Jin Kim , Sang Hyun Sung

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 3호 발행 연도 : 2018 페이지 : pp. 164-170 (7 pages)

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Rapid geographical classification of Bupleuri Radix is important in quality control. In this study, near infrared spectroscopy (NIRS) combined with supervised pattern recognition was attempted to classify Bupleuri Radix according to geographical origins. Three supervised pattern recognitions methods, partial least square discriminant analysis (PLS-DA), quadratic discriminant analysis (QDA) and radial basis function support vector machine (RBF-SVM), were performed to establish the classification models. The QDA and RBF-SVM models were performed based on principal component analysis (PCA). The number of principal components (PCs) was optimized by cross-validation in the model. The results showed that the performance of the QDA model is the optimum among the three models. The optimized QDA model was obtained when 7 PCs were used; the classification rates of the QDA model in the training and test sets are 97.8% and 95.2% respectively. The overall results showed that NIRS combined with supervised pattern recognition could be applied to classify Bupleuri Radix according to geographical origin.

KCI등재 SCOPUS

6Anti-inflammatory Potential of Artemisia capillaris and Its Constituents in LPS-induced RAW264.7 Cells

저자 : Qudeer Ahmed Abdul , Su Hui Seong , Bo Ra Ahn , Md Nurul Islam , Hyun Ah Jung , Jae Sue Choi

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 3호 발행 연도 : 2018 페이지 : pp. 171-180 (10 pages)

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Artemisia capillaris has been widely used as an alternative therapy for treating obesity and atopic dermatitis. It has been used as a hepatoprotactant. It is also used for ameliorating inflammatory reactions. Although there are several investigations on other Artemisia species, there is no systematic study describing the role of A. capillaris MeOH extract, its solvent soluble fractions, or derived anti-inflammatory principal components in regulating inflammatory conditions. Therefore, the objective of this study was to elucidate anti-inflammatory mechanisms of A. capillaris. Results revealed that MeOH extract of A. capillaris could decrease LPS-stimulated NO secretion. Of tested fractions, CH2Cl2, EtOAc, and n-BuOH strongly inhibited NO release from RAW264.7 cells. Bioactive mediators derived from CH2Cl2 and n-BuOH fractions elicited potent anti-inflammatory actions and strikingly abrogated LPS-triggered NO accumulation in RAW264.7 cells. Of particular interest, capillin and isoscopoletin possessed the most potent NO suppressive effects. Western blot analysis validated the molecular mechanism of NO inhibition and showed that capillin and isoscopoletin significantly down-regulated iNOS and COX-2 protein expression. Taken together, our results provide the first evidence that MeOH extract, CH2Cl2, EtOAc, and n-BuOH fractions from A. capillaris and its derived lead candidates can potently suppress inflammatory responses in macrophages by hampering NO release and down-regulating iNOS and COX-2 signaling.

KCI등재 SCOPUS

7Analysis of Essential oil, Quantification of Six Glycosides, and Nitric Oxide Synthase Inhibition Activity in Caryopteris incana

저자 : Agung Nugroho , Sang Kook Lee , Donghwa Kim , Jae Sue Choi , Kyoung-sik Park , Byong-min Song , Hee-juhn Park

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 3호 발행 연도 : 2018 페이지 : pp. 181-188 (8 pages)

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Caryopteris incana (Verbenaceae) has been used to treat cough, arthritis, and eczema in Oriental medicine. The two fractions (CHCl3- and BuOH fractions) and the essential oil of the plant material were subjected to the inducible nitric oxide synthase (iNOS) assay. The IC50 of the CHCl3 fraction and the essential oil on LPS-induced macrophage RAW 264.7 cells were 16.4 μg/mL and 23.08 μg/mL, respectively. On gas chromatography (GC)-mass spectroscopy (MS) analysis, twenty-five components representing 85.5% amount of total essential oil were identified. On the chromatogram, three main substances, trans-pinocarveol, cis-citral, and pinocarvone, occupied 18.8%, 13.5% and 18.37% of total peak area. Furthermore, by HPLC-UV analysis, six compounds including one iridoid (8-O-acetylharpagide)- and five phenylethanoid glycosides (caryopteroside, acteoside, phlinoside A, 6-O-caffeoylphlinoside, and leucosceptoside A) isolated from the BuOH fraction were quantified. The content of six compounds were shown as the following order: caryopteroside (162.35 mg/g) > 8- O-acetylharpagide (93.28 mg/g) > 6-O-caffeoylphlinoside (28.15mg/g) > phlinoside (22.60mg/g) > leucosceptoside A (16.87 mg) > acteoside (7.05 mg/g).

KCI등재 SCOPUS

8Chemical Investigation on an Endophytic fungus Gibberella moniliformis JS1055 Derived from a Halophyte Vitex rotundifolia

저자 : Jung Wha Kim , Jiyoung Ryu , Sang Hee Shim

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 3호 발행 연도 : 2018 페이지 : pp. 189-193 (5 pages)

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Chemical investigation of the ethyl acetate extract of Gibberella moniliformis JS1055 endophytic fungus derived from a halophyte, Vitex rotundifolia, led to the isolation of nine compounds including 7-butyl-6,8- dihydroxy-3(R)-pent-11-enylisochroman-1-one (1), 7-butyl-6,8-dihydroxy-3(R)-pentylisochroman-1-one (2), 7-butyl- 6,8-dihydroxy-3(R)-pentylisochroman-1-one (3), 5α,8α-epidioxyergosta-6,9(11),22-trien-3-ol (4), ergosterol peroxide (5), tetradecanoic acid (6), 8-O-methylfusarubin (7), nicotinic acid (8) and adenosine (9). They were identified by extensive spectroscopic data analysis including 1D, 2D (1H-1H COSY, HSQC, HMBC) NMR, and ESIMS. All the isolates (1 - 9) are reported for the first time from this endophytic fungus.

KCI등재 SCOPUS

9Chemicals from Cimicifuga dahurica and Their Inhibitory Effects on Pro-inflammatory Cytokine Production by LPS-stimulated Bone Marrow-derived Dendritic Cells

저자 : Nguyen Phuong Thao , Young Suk Lee , Bui Thi Thuy Luyen , Ha Van Oanh , Irshad Ali , Madeeha Arooj , Young Sang Koh , Seo Young Yang , Young Ho Kim

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 3호 발행 연도 : 2018 페이지 : pp. 194-198 (5 pages)

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Inflammation is a biological response caused by overactivation of the immune system and is controlled by immune cells via a variety of cytokines. The overproduction of pro-inflammatory cytokines enhances abnormal host immunity, resulting in diseases such as rheumatoid arthritis, cardiovascular disease, Alzheimer's disease, and cancer. Inhibiting the production of pro-inflammatory cytokines such as interleukin (IL)-12p40, IL-6, and tumor necrosis factor (TNF)-α might be one way to treat these conditions. Here, we investigated the anti-inflammatory activity of compounds isolated from Cimicifuga dahurica (Turcz.) Maxim., which is traditionally used as an antipyretic and analgesic in Korea. In primary cell culture assays, 12 compounds were found to inhibit the production of pro-inflammatory cytokines (IL-12p40, IL-6, and TNF-α) in vitro in bone marrow-derived dendritic cells stimulated with LPS.

KCI등재 SCOPUS

10Optimization of Extraction Conditions and Quantitative Analysis of Isoquercitrin and Caffeic Acid from Aster scaber

저자 : Ju Sung Lee , Norman G. Quilantang , Kung-woo Nam , Xiang-lan Piao , Mi Ja Chung , Sanghyun Lee

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 3호 발행 연도 : 2018 페이지 : pp. 199-205 (7 pages)

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To determine the optimum extraction conditions that give the highest yield of isoquercitrin and caffeic acid from Aster scaber, the effects of four extraction variables (solvent concentrations, extraction time, number of repeated extraction, and solvent volumes) on isoquercitrin and caffeic acid yield was examined via HPLC-UV. Our results showed that the highest extract and isoquercitrin yield were observed when A. scaber was extracted with 450 mL distilled water for 8 hr repeatedly for three times. In case of caffeic acid, the content was higher in the two repeated extracts. Also, content analysis of isoquercitrin in Aster species was performed in which A. fastigiatus, A. ageratoides, and A. scaber exhibited the highest isoquercitrin content at 6.39, 5.68, and 2.79 mg/g extract, respectively. In case of caffeic acid, the highest content of A. scaber and A. glehni was 0.64 and 0.56 mg/g extract, respectively. This study reports an optimized method for extraction of isoquercitrin and caffeic acid from A. scaber and evaluates potential sources of the compounds.

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서울대학교 롯데중앙연구소 Monash University 강원대학교 한국한의학연구원
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