간행물

한국생약학회> Natural Product Sciences

Natural Product Sciences update

  • : 한국생약학회
  • : 의약학분야  >  약화학
  • : KCI등재
  • : SCOPUS
  • : 연속간행물
  • : 계간
  • : 1226-3907
  • :
  • :

수록정보
수록범위 : 1권1호(1995)~24권1호(2018) |수록논문 수 : 1,026
Natural Product Sciences
24권1호(2018년) 수록논문
최근 권호 논문
| | | |

KCI등재 SCOPUS

1Lipids in Ginseng (Panax ginseng) and Their Analysis

저자 : So-hyun Kim , Seok-young Kim , Hyung-kyoon Choi

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 1호 발행 연도 : 2018 페이지 : pp. 1-12 (12 pages)

다운로드

(기관인증 필요)

키워드 보기
초록보기

Ginseng (Panax ginseng) is recognized as one of the most valuable medicinal herbs in Asia and it contains diverse phytochemicals that contribute to its pharmacological effects. Although lipids represent a major component of ginseng, ginseng lipids are still far from being fully explored. This review is focused on ginseng lipid components and methodologies of their analysis. The ginseng lipid compounds were categorized according to the structural features of each lipid class. This basic information on ginseng lipid components and the analysis methods will be applicable to authentification or quality control of ginseng products, and development of lipidbased pharmaceuticals and nutraceuticals from ginseng.

KCI등재 SCOPUS

2Estragole Exhibits Anti-inflammatory Activity with the Regulation of NF-κB and Nrf-2 Signaling Pathways in LPS-induced RAW 264.7 cells

저자 : Anupom Roy , Hee-juhn Park , Hyun Ah Jung , Jae Sue Choi

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 1호 발행 연도 : 2018 페이지 : pp. 13-20 (8 pages)

다운로드

(기관인증 필요)

초록보기

Estragole is a naturally occurring phenylpropanoid obtained from essential oils found in a broad diversity of plants. Although the phenylpropanoids show many biological activities, clear regulation of the inflammatory signaling pathways has not yet been determined. Here, we scrutinized the anti-inflammatory effect of estragole. The anti-inflammatory effect of estragole was determined through the inhibitory mechanisms of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2), nuclear factor kappa B (NF-κB), and mitogenactivated protein kinases (MAPK) pathways and the activation of nuclear factor erythroid 2-related factor 2 (Nrf- 2)/heme oxygenase (HO)-1 pathways in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Estragole significantly inhibited NO production, iNOS and COX-2 expression as well as LPS-induced NF-κB and MAPK activation. Furthermore, estragole suppressed LPS-induced intracellular ROS production but up-regulated the stress response gene HO-1 via the activation of transcription factor Nrf-2. These findings demonstrate that estragole inhibits the LPS-induced expression of inflammatory mediators via the down-regulation of iNOS, COX- 2, NF-κB, and MAPK pathways, as well as the up-regulation of the Nrf-2/HO-1 pathway, indicating that this phenylpropanoid has potential therapeutic and preventive applications in various inflammatory diseases.

KCI등재 SCOPUS

3The Amelioration Effect of the Ethanolic Extract of Cnidium officinale in Mice with Imiquimod-induced Psoriasis-like Skin Lesion

저자 : Yong Jun Lee , In Kee Hong , Hill Kim , Seong Il Heo , Dong-jo

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 1호 발행 연도 : 2018 페이지 : pp. 21-27 (7 pages)

다운로드

(기관인증 필요)

초록보기

Psoriasis is an auto-immune skin disease, which is characterized by the excessive generation of plaques on the skin with typically a long-lasting red, itchy and scaly symptoms. Imiquimod, which has been used for the treatment of external genital warts, actinic keratosis, and superficial basal cell carcinoma, induced of psoriasis-like skin disorders with skin erythema and thickness in mice. In the present study, we tried to find the bioactive herbal extract against imiquimod-induced psoriasis-like skin disorder in mice. During the searching of the herbal extract with anti-psoriatic effect, the ethanolic extract of Cnidium officinale ameliorated imiquimodinduced psoriasis-like skin disorder in mice. The morphological evaluation, H&E staining and Psoriasis Area and Severity Index (PASI) score showed that ear and back thickness, and erythema induced by imiquimod were significantly reversed after the treatment of the cream of the ethanolic extract of C. officinale. The overexpressed myeloperoxidase (MPO) and keratin 6A levels were decreased by the treatment of C. officinale cream. Also, IFN- γ, c-fos and IκB-α mRNA levels, which are related to the progression of psoriasis, were reduced by C. officinale cream. Thus, the ethanolic extract of C. officinale ameliorated psoriasis-like skin disorder induced by imiquimod and might be the therapeutic agent for psoriasis.

KCI등재 SCOPUS

4Pulegone Exhibits Anti-inflammatory Activities through the Regulation of NF-κB and Nrf-2 Signaling Pathways in LPS-stimulated RAW 264.7 cells

저자 : Anupom Roy , Hee-juhn Park , Qudeer Ahmed Abdul , Hyun Ah Jung ,

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 1호 발행 연도 : 2018 페이지 : pp. 28-35 (8 pages)

다운로드

(기관인증 필요)

초록보기

Pulegone is a naturally occurring organic compound obtained from essential oils from a variety of plants. The aim of this study was to investigate the anti-inflammatory effects through the inhibitory mechanism of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2), nuclear factor kappa B (NF-κB), mitogenactivated protein kinases (MAPK) pathways and the activation of nuclear factor erythroid 2-related factor 2 (Nrf2)/ heme oxygenase (HO)-1 pathways in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Results revealed that pulegone significantly inhibited NO production as well as iNOS and COX-2 expressions. Meanwhile, western blot analysis showed that pulegone down-regulated LPS-induced NF-κB and MAPKs activation in RAW 264.7 cells. Furthermore, the selected compound suppressed LPS-induced intracellular ROS production in RAW 264.7 cells, while the expression of stress response gene, HO-1, and its transcriptional activator, Nrf-2 was upregulated upon pulegone treatment. Taking together, these findings provided that pulegone inhibited the LPSinduced expression of inflammatory mediators via the down-regulation iNOS, COX-2, NF-κB, and MAPKs signaling pathways as well as up-regulation of Nrf-2/HO-1 indicating that pulegone has a potential therapeutic and preventive application in various inflammatory diseases.

KCI등재 SCOPUS

5Content Analysis of Rutin in the Leaves of Boehmeria nivea Harvested in Different Regions of South Korea by HPLC-UV

저자 : Sunghun Cho , Norman G. Quilantang , Ju Sung Lee , Young-mi Kim

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 1호 발행 연도 : 2018 페이지 : pp. 36-39 (4 pages)

다운로드

(기관인증 필요)

초록보기

Phytochemical analysis of Boehmeria nivea (Bn) leaves by medium pressure liquid chromatography led to the isolation of a flavonoid glycoside identified by spectroscopic analysis as rutin. The amount of rutin in the leaves of Bn harvested from nine regions in South Korea (Bn 1-9) which were collected on the months of June, July, August, and September was determined by HPLC-UV analysis. A gradient elution program that utilizes a Discovery® C18 (4.6 × 250 mm, 5 μm) column and mobile phase composed of 1% acetic acid-water: acetonitrile (90:10 to 60:40 for min) was followed. The injection volume and flow rate were 10 μl and 1 mL/ min, respectively. UV detection was set at 350 nm. Results show that Bn-8 harvested in September reported the highest content of rutin among the samples analyzed. This study provides a basis for the optimal harvest time of Bn which maximizes the yield of rutin.

KCI등재 SCOPUS

6Antioxidant and Anti-inflammatory Activity of Six Halophytes in Korea

저자 : Jeong Min Lee , Mi-jin Yim , Grace Choi , Myeong Seok Lee , Yu

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 1호 발행 연도 : 2018 페이지 : pp. 40-46 (7 pages)

다운로드

(기관인증 필요)

초록보기

The aim of this study was to measure and compare polyphenol content, antioxidant, and antiinflammatory activity of six halophytes (Limonium tetragonum, Suaeda glauca, Suaeda japonica, Salicornia europaea, Triglochin maritimum, and Sonchus brachyotus). Depending on the total polyphenol content, the plants were categorized into two groups: (1) a high total polyphenol content group that included L. tetragonum, S. brachyotus, and S. europaea, and, (2) a low total polyphenol content group consisting of S. glauca, T. maritima, and S. japonica. Antioxidant activity was evaluated using DPPH and hydroxyl radical scavenging assays, and by measuring ROS. Anti-inflammatory activity was evaluated by measuring NO and PGE2. L. tetragonum and S. brachyotus, that have high polyphenol content, also showed strong antioxidant activity. In addition, L. tetragonum, S. brachyotus, and S. europaea showed good anti-inflammatory activity. Consequently, the total polyphenol content was thought to be related to antioxidant and anti-inflammatory activity. Therefore, S. brachyotus and L. tetragonum are good candidates for use in pharmaceuticals and functional foods.

KCI등재 SCOPUS

7A Conformational Isomer of Soulattrolide from the Stem Bark of Calophyllum symingtonianum and Its Antibacterial Activity

저자 : Deny Susanti , Nissad Attoumani , Muhammad Taher , Mohd Fazlin Rez

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 1호 발행 연도 : 2018 페이지 : pp. 47-53 (7 pages)

다운로드

(기관인증 필요)

초록보기

Callophylum symingtonianum (Guttiferae), an evergreen broad-leaved tree that usually grows in hill forests, can be found distributed in the Malay Peninsula. The barks, leaves, flowers and seeds is often used medicinally to treat diarrhea and rheumatism. In the present study, we isolated two inophyllum type coumarins, 12-O-ethylinophyllum D (1) and iso-soulattrolide (2) from the stembarks of C. symingtonianum together with their antibacterial activity. The compounds were isolated by chromatographic methods on a silica gel. The structures were established by spectroscopic methods including UV, IR, (1D and 2D) NMR and mass spectrometry as well as by comparison with several literature sources. The antibacterial activity of those compounds was tested using a disc-diffusion assay against Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. Both compound exhibited mild inhibition against P. aeruginosa with both 111 μg/ml MIC value. Compound 2 also inhibits S. aureus with 25 μg/ml MIC value.

KCI등재 SCOPUS

8A New Steroidal Glycoside from Allium macrostemon Bunge

저자 : Yun Sik Kim , Joon Min Cha , Dong Hyun Kim , Tae Hyun Lee , Ka

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 1호 발행 연도 : 2018 페이지 : pp. 54-58 (5 pages)

다운로드

(기관인증 필요)

초록보기

A phytochemical investigation of Allium macrostemon Bunge (Liliaceae) afforded the new pregnane steroidal glycoside, named allimacroside F (1), along with three known glycosides, benzyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (2), phenylethyl-O-α-L-rhamnopyranosyl-(1 →6)-β-D-glucopyranoside (3), (Z)-3-hexenyl-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (4). The identification and structural elucidation of a new compound (1) was carried out based on spectral data analyses (1H-NMR, 13C-NMR, 1H-1H COSY, HSQC, HMBC, and NOESY) and HR-FAB-MS.

KCI등재 SCOPUS

9Lignans with NADPH Oxidase 2 (NOX2)-inhibitory Activity from the Fruits of Schisandra chinensis

저자 : Jung-min Park , Pisey Pel , Young-won Chin , Moo-yeol Lee

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 1호 발행 연도 : 2018 페이지 : pp. 59-65 (7 pages)

다운로드

(기관인증 필요)

초록보기

An isoform of NADPH oxidase (NOX), NOX2 is a superoxide-generating enzyme involved in diverse pathophysiological events. Although its potential as a therapeutic target has been validated, there is no clinically available inhibitor. Herein, NOX2-inhibitory activity was screened with the constituents isolated from Schisandra chinensis, which has been reported to have antioxidant and reactive oxygen species (ROS)-scavenging effects. Among the partitions prepared from crude methanolic extract, a chloroform-soluble partition showed the highest NOX2-inhibitory activity in PLB-985 cell-based NOX2 assay. A total of twenty nine compounds (1 - 29) were identified from the chloroform fraction, including two first isolated compounds; dimethyl-malate (25) and 2- (2-hydroxyacetyl) furan (27) from this plants. Of these constituents, two compounds (gomisin T, and pregomisin) exhibited an NOX2-inhibitory effect with the IC50 of 9.4 ± 3.6, and 62.9 ± 11.3 μM, respectively. They are confirmed not to be nonspecific superoxide scavengers in a counter assay using a xanthine-xanthine oxidase system. These findings suggest the potential application of gomisin T (6) and other constituents of S. chinensis to inhibit NOX2.

KCI등재 SCOPUS

10Chemical Composition and Antimicrobial Efficacy of Helminthostachys zeylanica against Foodborne Bacillus cereus

저자 : Tong Woei Yenn , Leong Chean Ring , Khairul Azly Zahan , Muhammad

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 24권 1호 발행 연도 : 2018 페이지 : pp. 66-70 (5 pages)

다운로드

(기관인증 필요)

초록보기

Helminthostachys zeylanica is a rare plant grows in lightly shaded areas. The fern was traditionally used as antipyretic and antiphlogistic agents. This study was aimed to evaluate the antibacterial potential of H. zeylanica on foodborne Bacillus cereus. The chemical composition of its ethanolic extract was also determined. The plant samples were collected at Kampung Kebun Relong, Kedah, Malaysia. The ethanolic extract showed significant inhibitory activity on B. cereus with a sizeable clear zone detected on disc diffusion assay. On broth microdilution assay, the MIC of the extract on B. cereus was 6.25 mg/ml and the MBC was 12.5 mg/ml. The inhibitory activity of the extract on B. cereus was bactericidal. In the growth dynamic study, the antibacterial efficacy of the extract was concentration dependent, where a lower colony forming unit count was obtained with increased extract concentration. The SEM micrograph of extract treated B. cereus cells showed invaginations of cell wall. The bacterial cell structure collapsed after 24 h exposure to the extract. The GCMS analysis of the extract showed that the major constituents of the extract were phenol (36.26%) and quercetin (29.70%). This study is important as it shows the potential use of H. zeylanica as an effective agent to control B. cereus related infections.

12
권호별 보기
가장 많이 인용된 논문

(자료제공: 네이버학술정보)

가장 많이 인용된 논문
| | | |
1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

다운로드

2미국의 비트코인 규제

(2006)홍길동심리학41회 피인용

다운로드

가장 많이 참고한 논문

(자료제공: 네이버학술정보)

가장 많이 참고한 논문

다운로드

2미국의 비트코인 규제

(2006)홍길동41회 피인용

다운로드

해당 간행물 관심 구독기관

강원대학교 경북대학교 서울대학교 단국대학교 전북대학교
 11
 8
 8
 4
 3
  • 1 강원대학교 (11건)
  • 2 경북대학교 (8건)
  • 3 서울대학교 (8건)
  • 4 단국대학교 (4건)
  • 5 전북대학교 (3건)
  • 6 대구한의대학교(구 경산대학교) (2건)
  • 7 동의대학교 (2건)
  • 8 경희대학교 (2건)
  • 9 농촌진흥청 (2건)
  • 10 광운대학교 (2건)

내가 찾은 최근 검색어

최근 열람 자료

맞춤 논문

보관함

내 보관함
공유한 보관함

1:1문의

닫기