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생약학회지 update

Korean Journal of Pharmacognosy

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수록정보
수록범위 : 1권1호(1970)~51권4호(2020) |수록논문 수 : 3,317
생약학회지
51권4호(2020년 12월) 수록논문
최근 권호 논문
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KCI등재 SCOPUS

1콜라겐 유도의 혈소판에서 사이클릭 뉴클레오티드의 조절을 통한 Euchrestaflavone B의 혈전 형성 억제 효과

저자 : 권혁우 ( Hyuk-woo Kwon )

발행기관 : 한국생약학회 간행물 : 생약학회지 51권 4호 발행 연도 : 2020 페이지 : pp. 231-237 (7 pages)

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Euchrestaflavanone B (EFB) is a flavonoid that can be found in root bark, particularly in Cudrania tricuspidata (C. tricuspidata). The extract of C. tricuspidata is widespread throughout Asia and used in traditional medicine. In a previous study, we found anti-platelet effects of substances isolated from C. tricuspidata on collagen-induced human platelets. However, the C. tricuspidata still contains numerous substances, thus, we have searched new candidate, EFB isolated from C. tricuspidata for anti-platelet effect. Our results showed that EFA inhibited collagen-induced platelet aggregation and glycoprotein IIb/IIIa (αIIb/β3)-mediated signaling events, including platelet adhesion, granule secretion, thromboxane A2 production and clot retraction. These results suggest that EFA has inhibitory effects on human platelet activities and thrombus formation and has potential value as a natural substance for preventing platelet-induced thrombosis.

KCI등재 SCOPUS

2자소엽에서 분리된 트리테르페노이드의 베타-아밀로이드 응집 억제 효과

저자 : 여지윤 ( Ji-yun Yeo ) , 이충현 ( Chung-hyun Lee ) , 박소영 ( So-young Park )

발행기관 : 한국생약학회 간행물 : 생약학회지 51권 4호 발행 연도 : 2020 페이지 : pp. 238-243 (6 pages)

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Perilla frutescens Britton var. acuta Kudo, an annual plant primarily cultivated in China, Japan, and Korea, has been used as a traditional medicine to treat inflammatory diseases, depression, and many anxiety-related disorders. Previously, we reported the inhibitory effects of n-hexane layer of P. frutescens var. acuta extract against beta-amyloid (Aβ) aggregation, and the isolation of asarone derivatives as active constituents from n-hexane layer. In this study, dichloromethane layer of P. frutescens var. acuta was applied to bioassay-guided isolation methods accompanied with Thioflavin T (Th T) fluorescence assay to investigate the inhibitory effect on Aβ aggregation and disaggregation. As the results, three triterpenoids including ursolic acid (1), tormentic acid (2) and corosolic acid (3) were isolated. All compounds reduced Aβ aggregation and increased disaggregation of preformed Aβ aggregates in a dose-dependent manner. However, the inhibitory effect of three compounds on Aβ aggregation was not correlated with antioxidant activity, which was measured by DPPH assay. Taken together, these results suggest that the triterpenoid derivatives from P. frutescens have the potential to be developed as good therapeutics or preventatives for AD.

KCI등재 SCOPUS

3백출에서 분리된 Atractylenolide II의 RAW264.7 대식세포와 BV2 미세아교세포에서의 항염증 효과

저자 : 김홍광 ( Hong-guang Jin ) , 김관우 ( Kwan-woo Kim ) , 이정 ( Jing Li ) , 임혜리 ( Hyeri Im ) , 이대영 ( Dae Young Lee ) , 윤다혜 ( Dahye Yoon ) , 정진태 ( Jin Tae Jeong ) , 김금숙 ( Geum-soog Kim ) , 오현철 ( Hyuncheol Oh ) , 안인파 ( Ren-bo An ) , 김윤철 ( Youn-chul Kim )

발행기관 : 한국생약학회 간행물 : 생약학회지 51권 4호 발행 연도 : 2020 페이지 : pp. 244-254 (11 pages)

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Atractylodes macrocephala is a perennial herb and is a member of the Compositae family. This plant is known to contain various bioactive constituents indicating anti-inflammatory, neuroprotective, anti-oxidant, immunological enhancement, and gastroprotective effects. In this investigation, we isolated four compounds with similar chemical structures from A. macrocephala, and evaluated their anti-inflammatory effects. Among the four compounds, compound 2(atractylenolide II) showed the second-best inhibitory effect on the lipopolysaccharide(LPS)-induced production of nitric oxide in RAW264.7 macrophages and BV2 microglial cells. Compound 2 also inhibited the LPS-induced the production of prostaglandin E2(PGE2), and the expression of inducible nitric oxide synthase(iNOS) and cyclooxygenase(COX)-2 proteins in both cells. In addition, compound 2 suppressed the production of pro-inflammatory cytokines including interleukin(IL)-1β, IL-6, and tumor necrosis factor(TNF)-α. These inhibitory effects were contributed by inactivation of nuclear factor kappa B(NF-κB) and mitogen-activated protein kinases(MAPKs) pathways by treatment with compound 2. This compound did not induce the expression of heme oxygenase(HO)-1 protein indicating that the anti-inflammatory effect of compound 2 was independent with HO-1 protein. Taken together, these results suggested that atractylenolide II can be a candidate material to treat inflammatory diseases.

KCI등재 SCOPUS

4인삼의 열처리 과정 중 생성되는 3종의 수산화진세노사이드에 대한 연구

저자 : 이상명 ( Sang Myung Lee )

발행기관 : 한국생약학회 간행물 : 생약학회지 51권 4호 발행 연도 : 2020 페이지 : pp. 255-263 (9 pages)

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Ginsenosides are considered to be the most important ingredients in ginseng. They are chemically converted by endogenous organic acids contained in ginseng and the heat applied during red ginseng processing. During this procedure, various converted ginsenosides are produced through hydrolysis of substitute sugars of ginsenosides and forming double bonds through dehydration in the dammarane skeleton. In order to study the conversion mechanism of protopanaxadiol-type ginsenosides during the heat treatment process of ginseng, we purified the three final converted ginsenosides by heating fresh ginseng for a long time. The three isolated ginsenosides were identified as 25(OH)-ginsenoside Rg5, 25(OH)-ginsenoside Rz1 and 25(OH)-ginsenoside Rg3 through NMR spectrum analysis. As a result of quantification of ginseng heated at 100 °C for 0 to 6 days by HPLC/UV and TLC methods, the content of 25(OH)-ginsenosides tended to increase in proportion to the time exposed to heat. In particular, the content of 25(OH)-ginsenosid Rg5 was confirmed to be noticeably increased.

KCI등재 SCOPUS

5세신 비극성 분획의 항암 활성 및 성분 분석

저자 : 조승식 ( Seung-sik Cho ) , 강복윤 ( Bok Yun Kang ) , 배민석 ( Min-suk Bae ) , 심정현 ( Jung-hyun Shim ) , 김현정 ( Hyun Jung Kim ) , 윤구 ( Goo Yoon )

발행기관 : 한국생약학회 간행물 : 생약학회지 51권 4호 발행 연도 : 2020 페이지 : pp. 264-269 (6 pages)

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The study aimed to characterize chemical composition and anticancer property of the n-hexane fraction derived from Asiasari Radix et Rhizoma. The anticancer activity was evaluated on a panel of cancer cell lines including HN22, HSC2, HSC3, and HSC4 cells (human oral cancer), HCC827 and HCC827GR cells (human lung cancer), and KYSE30 and KYSE450 (human esophageal cancer) by MTS assay. As a result, The least polar subfraction from n-hexane-soluble layer displayed notable cytotoxicity on the tumor cell lines with IC50 ranging from 1.20 to 17.0 μg/ml. The chemical composition of constituents in the active subfraction was determined by gas chromatography-mass spectrometry (GC-MS). The essential oils comprised of sesquiterpenes including β-gurjunene (7.45%), γ-amorphene (6.61%), guaia-6,9-diene (6.40%), δ-guaiene (5.21%) and a phenylpropanoid, safrole (0.49%) were mainly identified in addition to long-chain hydrocarbons including n-heptadecane (24.60%), 7-hexadecene (4.44%) and a diterpenoid, ent-kaur-16-ene (6.57%).

KCI등재 SCOPUS

6LC-MS/MS를 이용한 종자류 생약의 곰팡이독소 동시분석 및 위해도 평가

저자 : 최은정 ( Eun Jung Choi ) , 박영애 ( Young Ae Park ) , 최수정 ( Su Jeong Choi ) , 정삼주 ( Sam Ju Jung ) , 박윤선 ( Youn Sun Park ) , 황인숙 ( In Sook Hwang ) , 유인실 ( In Sil Yu ) , 신기영 ( Gi Young Shin )

발행기관 : 한국생약학회 간행물 : 생약학회지 51권 4호 발행 연도 : 2020 페이지 : pp. 270-277 (8 pages)

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This study analyzed mycotoxins, aflatoxin B1, B2, G1, G2, fumonisin B1, B2, ochratoxin A and zearalenone, using LC-MS/MS and conducted risk assessment on 54 samples of seeds distributed in SeoulYangnyeongsi and the management status of extramural herbal dispensary facility. The matched calibration showed a good linearity as observed in 6 concentration levels(r2>0.999) as a result of method validation applied with Arecae semen. Limits of detection(LOD) and quantification( LOQ) were in the range of 0.02-0.11 μg/kg and 0.08-0.34 μg/kg, respectively. Recoveries also estimated, ranging from 65.1-99.7% with relative standard deviation(RSD) 0.5-6.3%. As a result of the method on 54 samples, mycotoxins were detected in 16 samples. Among them, two Thujae semen showed a degree of concentration that exceeded the aflatoxin specification. In the risk assessment, the human exposure safety standard values were calculated as ADI(Acceptable Daily Intake) for aflatoxin B1, fumonisin and zearalenone. Ochratoxin A was calculated as PTWI(Provisional Tolerable Weekly Intake). The MOE(Margine of Exposure) of aflatoxin B1 was in the range of 40.36-3536.88. And no items exceeded 100% in %TDI(Tolerable Daily Intake) and %TWI(Tolerable Weekly Intake) of fumonisin, zearalenone and ochratoxin A.

KCI등재 SCOPUS

7복합생약 HO-Series의 숙취개선 임상적 유용성 평가

저자 : 장보윤 ( Bo Yoon Chang ) , 배진혜 ( Jin Hye Bae Da Eun Kim ) , 김다은 ( Dae Sung Kim ) , 김대성 ( Hyoung Kwon Cho ) , 조형권 ( Sung Yeon Kim ) , 김성연

발행기관 : 한국생약학회 간행물 : 생약학회지 51권 4호 발행 연도 : 2020 페이지 : pp. 278-290 (13 pages)

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The purpose of this study is to investigate the hangover relieving effect of HO-series. HO-S1 is an herbal mixture, which consists of extracts from Flower of Pueraria lobata Ohwi, Glycyrrhiza glabra Linne, Fruit of Lycium chinense Miller, Poria cocos Wolf, Acanthopanax sessiliflorum Seeman, Scutellaria baicalensis Georgi, Atractylodes lancea De Candlle and Zingiber officinale Roscoe. HO-S2 is a candidate that has been performed to ultra filtration based on HO-S1. HO-S3 is a mixture of amino acids and vitamins based on HO-S2. HO-01 is the final beverage base produced based on HO-S3. The antioxidant activity of HO-series was similar to that of vitamin C or trolox. The production of t-BHP induced reactive oxygen species(ROS) was significantly blocked in the presence of HO-series. In vivo study, AUC of alcohol and acetaldehyde concentrations in HO-S2 and HO-S3 treated groups significantly decreased. Hepatic alcohol dehydrogenase(ADH) and acetaldehyde dehydrogenase( ALDH) activity were significantly higher in HO-S2 and HO-S3 treated groups. And 2E1 activity and glutathione were significantly elevated, while the malondialdehyde level was not significantly in liver tissue. After alcohol exposure, the sensitivity scores of blood alcohol and acetaldehyde concentration and hangover symptoms were significantly decreased in the HO-01 intake group compared with the non-intake group. ALDH activity was significantly increased in the HO-01 intake group. HO-series have antioxidant activity and a protective effect from ROS. HO-S2, HO-S3 and HO-01 are potentially highly beneficial in relieving hangover, as it scavenges reactive free radicals and boosts the endogenous antioxidant system.

KCI등재 SCOPUS

8터리풀의 채집장소 및 채집시기에 따른 카테킨 함량 HPLC/UV 분석

저자 : 이학동 ( Hak-dong Lee ) , 이윤지 ( Yunji Lee ) , 김훈 ( Hoon Kim ) , 김한근 ( Hangeun Kim ) , 박춘근 ( Chun-gun Park ) , 이상현 ( Sanghyun Lee )

발행기관 : 한국생약학회 간행물 : 생약학회지 51권 4호 발행 연도 : 2020 페이지 : pp. 291-296 (6 pages)

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Filipendula glaberrima (FG) is a plant endemic to South Korea. It is economically important as a food source and used as a medicine in treating ailments. Filipendula flowers are characterized by the presence of several polyphenolic constituents. The aim of this study is to determine the content of (+)-catechin in Filipendula glaberrima collected from different regions at different flowering stages. High-performance liquid chromatography with a gradient elution system (0.5% acetic acid in water : acetonitrile = 95 : 5 to 0 : 100 for 35 min) was used. A reverse-phase INNO column with UV detection at 278 nm was employed. The results revealed that F. glaberrima from Mt. Odae has the highest (+)-catechin content (10.600 mg/g). Furthermore, its content was the lowest in samples collected during the pre-flowering period and the highest at the early-flowering stage. This study provides a basis in establishing the optimal period and the best region for collecting F. glaberrima with maximized (+)-catechin yield.

KCI등재 SCOPUS

9HPLC 분석을 통한 한국산 밀크씨슬 중 실리마린과 실리빈의 정량

저자 : 김주리 , 레오아드리안바헤 , 최중원 , 이학동 , 심재석 , 심지형 , 폴존헤랄디노 , 이상현

발행기관 : 한국생약학회 간행물 : 생약학회지 51권 4호 발행 연도 : 2020 페이지 : pp. 297-301 (5 pages)

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Silymarin (SM) and silybin diastereomers (SD) in milk thistle (Silybum marianum) were determined using high-performance liquid chromatography and quantified using a reverse-phase column in a gradient elution system. UV detection was performed at 288 nm. The content of SM and SD in milk thistle was 3.236 and 0.553 mg/g DW, respectively. Determining the presence and quantifying the content of SM and SD in milk thistle are vital for the pharmaceutical industry to identify optimal sources for developing health supplements or therapeutics.

KCI등재 SCOPUS

10붉나무 캘러스 유도 및 그 추출물로부터 피부미백 효과에 관한 연구

저자 : 김동명 ( Dong-myong Kim ) , 정주영 ( Ju-yeong Jung ) , 이형곤 ( Hyung-kon Lee ) , 권용성 ( Yong-seong Kwon ) , 백진홍 ( Jin-hong Baek ) , 이관호 ( Kwan-ho Lee ) , 장진훈 ( Jin-hoon Jang ) , 한인석 ( In Suk Han )

발행기관 : 한국생약학회 간행물 : 생약학회지 51권 4호 발행 연도 : 2020 페이지 : pp. 302-309 (8 pages)

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The objective of this study was to optimize the condition for induction and proliferation of callus from Rhus chinensis Mill. and investigate the skin-brightening effect of Rhus chinensis callus (RCC). It was confirmed that the most proper plant growth regulator (PGR) for callus induction is 1.0 mg/L of 2,4-dichlorophenoxyacetic acid (2,4-D). The most optimal condition of PGR, medium and additives for callus proliferation were 2,4-D (1.0 mg/L), MS medium and citric acid, respectively. Inhibitory activities of tyrosinase were higher at 50 and 100 μg/mL of RCC extracts (41.86 and 75.56%, respectively) than arbutin (27.32%). As the results of measuring melanin inhibition in B16F1 melanocyte and B16F10 melanoma cell, RCC extracts increased its inhibitory activities concentration-dependently, and were found to have higher whitening effect than arbutin at a concentration of 100 μg/mL. Therefore, it is suggested that RCC can be used as an effective material for skin-brightening cosmetics.

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1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

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2미국의 비트코인 규제

(2006)홍길동심리학41회 피인용

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2미국의 비트코인 규제

(2006)홍길동41회 피인용

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