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대한본초학회지(본초분과학회지) update

The Korea Jounrnal of Herbology

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수록정보
수록범위 : 1권0호(1986)~35권3호(2020) |수록논문 수 : 1,591
대한본초학회지(본초분과학회지)
35권3호(2020년 05월) 수록논문
최근 권호 논문
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KCI등재

1갈화(葛花)와 진피(陳皮) 추출물로 이루어진 복합물의 에스트로겐 활성과 파골세포 분화억제효과

저자 : 조호성 ( Hosong Cho ) , 이보영 ( Boyoung Lee ) , 이원경 ( Won Kyung Lee ) , 이준호 ( Jun Ho Lee ) , 박동준 ( Dongjun Park ) , 최창일 ( Changil Choi ) , 진무현 ( Mu Hyun Jin ) , 노석선 ( Seok-seon Roh ) , 주영승 ( Young-sung Ju )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 3호 발행 연도 : 2020 페이지 : pp. 1-8 (8 pages)

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Objectives: In this study, we examined the estrogenic activities and anti-osteo clastogenesis effects of PCE17, a mixture of PE (an extract of Puerariae Flos), and CE (an extract of Citri Unshius Pericarpium).
Methods: The estrogenic effect of PCE17, PE and CE were examined by ER-β/ERE reporter gene assay and proliferation assay in 293 T and MCF-7 cells. The expression of estrogen-responsive gene and protein were checked by Real Time-PCR (RT-PCR) and Western blotting in MCF-7 cells. Inhibitory effect of PCE17, PE and CE on RANKL-induced osteoclast differentiation were evaluated by TRAP staining and RT-PCR in primary osteoclast precursors from rat bone marrow cells.
Results: PCE17 and PE bind to ERs (estrogen receptors) and show estrogenic activities in 293T cells. They also stimulated the proliferation of MCF-7 cells and increased the expression of ER response gene, pS2. Tectorigenin, an active ingredient of PE, shows similar estrogenic activities in MCF-7 cells. PCE17 and CE inhibited RANKL-induced osteoclastogenesis in rat primary osteoclast precursor cells and down-regulated the osteoclast-specific genes of Nfatc1, Ctsk, and Acp5.
Conclusions: In conclusion, PCE17 may have therapeutic potential in cases of menopause and osteoporosis.

KCI등재

2건칠(乾漆) 열수 추출물이 근원세포의 근분화에 미치는 영향

저자 : 이상수 ( Sangsoo Lee ) , 김은미 ( Eun-mi Kim ) , 조남준 ( Namjoon Cho ) , 한효상 ( Hyosang Han ) , 김기광 ( Kee Kwang Kim )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 3호 발행 연도 : 2020 페이지 : pp. 9-16 (8 pages)

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Objectives: Sarcopenia is a disease that leads to a decrease in skeletal muscle, and the importance of prevention and treatment thereof is increasing in an aging society. However, there is a definite limitation of exercise therapy for sarcopenia, and thus, there is an urgent need for a pharmacologic research to the treatment of sarcopenia.
Methods: 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS) assay was performed to confirm the antioxidant efficacy of water extract of Lacca Sinica Exsiccata (WELSE). To determine the effect of WELSE on myoblast activity, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay was performed. To confirm the effect of WELSE on the differentiation of myoblast into myotubes, protein expression levels of myosin heavy chain 3 (Myh3) and paired box 3/7 (pax3/7) were confirmed by immunoblot analysis. In addition, immunofluorescence microscopy was performed to confirm the effect on myotube formation of WELSE.
Results: It was confirmed that WELSE had high antioxidant activity and showed no cytotoxicity to myoblast up to 200 ㎍/㎖ concentration. Myoblast was treated with WELSE at a concentration of 100 ㎍/㎖ and differentiated for 5 days. The expression of Myh3, which forms myotubes, was promoted and the morphology of myotubes was changed and Increasing the thickness.
Conclusions: In this paper, we confirmed the excellent antioxidant efficacy of WELSE and positive effects on muscle differentiation and myotube formation. These results suggest valuable as a material for pharmaceutical research on the prevention and treatment of sarcopenia.

KCI등재

3위궤양 유발 마우스모델에서 강황(薑黃) 추출물의 위 보호 효과

저자 : 오민혁 ( Min Hyuck Oh ) , 김민주 ( Min Ju Kim ) , 신미래 ( Mi-rae Shin ) , 박해진 ( Hae-jin Park ) , 서부일 ( Bu-il Seo ) , 노성수 ( Seong-soo Roh )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 3호 발행 연도 : 2020 페이지 : pp. 17-24 (8 pages)

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Objectives: The objective of this study was to evaluate the gastric protective effect of Curcuma Longae Rhizoma (CLR) in 150 mM HCl/60% ethanol induced gastric ulcer (GU) in mice.
Methods: Forty ICR mice were divided into five groups (n=8/Group): Nor group; Normal, Veh group; GU control, SC group; GU + sucralfate 10 ㎎/㎏, CL; GU + CLR 30% ethanol extract 100 ㎎/㎏, CH group; GU + CLR 30% ethanol extract 200 ㎎/㎏. Then, mice were orally administered with 150 mM HCl/60% ethanol and caused GU. After 1 hr, mice were sacrificed, and blood and stomach tissue were collected.
Results: CLR showed significance scavenging effects in 1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azinobis-3- ethyl-benzothiazoline-6-sulfonic acid (ABTS) radical scavenging activities (DPPH IC50; 78.18 ± 0.60 ㎍/㎖, ABTS IC50; 55.91 ± 1.86 ㎍/㎖). CLR significance reduce inflammatory-related factors such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), and interleukin-6 (IL-6) via nuclear factor kappa B (NF-κB) inactivation. In addition, the activation of nuclear factor erythroid2-related factor 2 (Nrf2) significantly led to up-regulation of anti-oxidant enzymes including factors heme oxygenase-1 (HO-1), super oxide dismutase (SOD), and glutathione peroxidase-1/2 (GPx-1/2).
Conclusions: Our discovery provides that CLR possesses anti-oxidant and anti-inflammatory effects. Hence, CLR may ameliorate the development of gastric ulcer though the inhibition of NF-κB inflammatory pathway and the elevation of Nrf2 anti-oxidant pathway.

KCI등재

4블루베리 열수 추출물의 근아세포의 근분화에 미치는 영향

저자 : 최영수 ( Youngsoo Choi ) , 김은미 ( Eunmi Kim ) , 최선경 ( Sunkyung Choi ) , 이웅희 ( Woonghee Lee ) , 한효상 ( Hyosang Han ) , 김기광 ( Keekwang Kim )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 3호 발행 연도 : 2020 페이지 : pp. 25-32 (8 pages)

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Objectives: At present, aging-related degenerative muscle diseases are considered a serious problem. However, the effects on muscles regarding the efficacy of blueberry have not been studied. In this study, we tried to find out the correlation between blueberry and muscle.
Methods: 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS) assay was performed to confirm the antioxidant efficacy of blueberry hydrothermal extract. To determine the effect of blueberry hydrothermal extracts (BHE) on myoblast activity, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2Htetrazolium (MTS) assay was performed. To confirm the effect of blueberry hydrothermal extracts on the differentiation of myoblast into myotubes, protein expression levels of myosin heavy chain 3 (Myh3) and paired box 3/7 (pax3/7) were confirmed by immunoblot analysis. In addition, immunofluorescence microscopy was performed to confirm the effect on myotube formation of blueberry hydrothermal extracts.
Results: Antioxidative efficacy and low toxicity were confirmed through ABTS assay and MTS assay of blueberry extract for myoblasts. As a result of immunoblot analysis and immunofluorescence analysis, the decrease in myogenic marker Pax3/7 was not confirmed, but myotubes The specific expression inhibitory activity of the forming protein Myh3 was confirmed. Through this, it was confirmed that the blueberry extract has a negative activity against myoblast differentiation.
Conclusion: This experiment confirmed that blueberry hydrothermal extract has excellent antioxidant efficacy and negative results in inhibiting the differentiation and proliferation of myoblast. This requires deep study of certain ingredients and requires reassessment of the dietary intake of blueberries.

KCI등재

5배합 비율에 따른 황련과 황금의 혼합 전탕액 및 개별 전탕 혼합액 내 성분 함량 분석

저자 : 김한영 ( Han-young Kim ) , 김정훈 ( Jung-hoon Kim )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 3호 발행 연도 : 2020 페이지 : pp. 33-45 (13 pages)

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Objective : The present study aimed to evaluate the change of the content of 7 active components in decoctions produced by various proportional pairs of Coptis chinensis Franch and Scutellaria baicalensis Georgi in 'Mixed decoction (MD)' and 'Single decoction mixture (SDM)'.
Methods: The samples of MDs were prepared by decocting C. chinensis: S. baicalensis with the ratios of 10 g:10 g, 10 g:20 g, and 20 g:10 g. Those of SDMs were prepared by blending each single decoction from C. chinensis and S. Baicalensis with the ratios of 1:1, 1:2, and 2:1. The samples were evaluated by high-performance liquid chromatography with statistical analyses.
Results: The analytical methods, which were optimized and validated, were reliably applied to present research. The content of all components in both MDs and SDMs at C. chinensis: S. baicalensis = 1:1 ratio were reduced compared with single herb decoction. The components from each compositional herb in MDs were proportionally increased with the ratio of original herb increased, but inversely proportional to paired herb. The contents of components in MDs were significantly lower than those in SDMs at all ratios, except for high content of baicalin at C. chinensis: S. baicalensis = 2:1.
Conclusion: It was concluded that MDs and SDMs as well as the proportions of herbs could affect the contents of the components from original herbal medicines. These results provide the information for the quality control of herbal medicine combined C. chinensis with S. baicalensis.

KCI등재

6대황목단탕의 메티실린 내성 황색 포도상구균에 대한 항균활성

저자 : 한형선 ( Han Hyoung-sun ) , 권동렬 ( Dong-yeul Kwon ) , 강옥화 ( Ok-hwa Kang )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 3호 발행 연도 : 2020 페이지 : pp. 47-54 (8 pages)

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Objective: Infectious diseases are a growing problem worldwide by Methicillin-resistant Staphylococcus aureus (MRSA). Daehwangmokdan-tang is one of the oriental medicine prescriptions contained in Principles and Practice of Eastern Medicine. This study investigated the antibacterial activity of EtOH 70% extracts of Daehwangmokdan-tang (DMT) which prescription is composed of oriental medicine against MRSA.
Methods: The antimicrobial activity and active concentration of MRSA were verified by measuring the minimum inhibitory concentration (MIC) of DMT. In addition, the effects of the disease were checked by treating the existing antibiotics and large ethanol extract in parallel, and the extent of growth suppression was checked over time. In addition, cell membrane permeability experiment confirmed the effect of large DMT on the immunity mechanism of MRSA.
Results: TThe minimum inhibitory concentration of DMT against MRSA is 500 ~ 2000 ㎍/㎖ by broth dilution method. In the checkerboard method, the combinations of DMT with antibiotics has partial synergistic effect or synergy effect and DMT markedly reduced the MICs of the antibiotics oxacillin (OX), gentamicin (GEN) against MRSA. In the inhibition of resistance mechanism of DMT against MRSA, the expression of resistance gene and protein about β-lactam antibiotic was reduced. Also, we observed the effect of DMT about cell membrane permeability against MRSA, and confirmed that DMT suppressed growth of strains by increasing cell membrane permeability and energy metabolism.
Conclusion: Basis on the result, we speculate that DMT may be useful for the treatment of MRSA infections when used in combination with β-lactam antibiotic.

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