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대한본초학회지(본초분과학회지) update

The Korea Jounrnal of Herbology

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수록정보
수록범위 : 1권0호(1986)~35권6호(2020) |수록논문 수 : 1,611
대한본초학회지(본초분과학회지)
35권6호(2020년 11월) 수록논문
최근 권호 논문
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KCI등재

1한국산 지치과 식물에 관한 본초학적 연구

저자 : 이숭인 ( Soong-in Lee ) , 전의상 ( Ui-sang Jeon ) , 정종길 ( Jong-gil Jeong )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 6호 발행 연도 : 2020 페이지 : pp. 1-9 (9 pages)

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Objective : For the purpose of developing Boraginaceae plants recorded in Korean Herbology in Korea, the literatures of the successive generations have been thoroughly investigated to prepare this article. Methods : Books and research papers about Herbology which published at Korea and other countries were examined.
Results : A list was made about Boraginaceae plant which were cultivated or grew naturally in Korea, after investigated the data on domestic and foreign Boraginaceae plants. Boraginaceae(grew in Korea) were divided into 14 classes with 24 species. Out of those, 6 classes with 9 species were found serviceable which indicates 37.5% of all. Out of all 24 species of Boraginaceae family, Trigonotis genus were found 5 species, which were shown the most. Among 3 genus of Lithospermum species, medicinal plants were all one species each. Out of all serviceable parts in Boraginaceae, Herb·Radix·Fructus parts took first place as 3 species. There are 2 species toxic, the survey said. 3 Classifying medicinal plants among the Borginaceae plants by part, whole herbs, roots, and fruits are found to be 3 separate species each. When it comes to the nature of taste, 5 kinds of taste without action and seven kinds of bitter taste are the most common. For channel tropism, liver channel has the largest number of 5 types.
Conclusion : There were totaled to 14 genera and 24 species in Boraginaceae in Korea and among them medicinal plants are 6 genera, 9 species, some 37.5% in total.

KCI등재

2감초 신품종 및 약전 수재감초의 면역조절 효과 비교 연구

저자 : 강윤미 ( Yun-mi Kang ) , 김원남 ( Wonnam Kim ) , 진종식 ( Jong-sik Jin ) , 이종현 ( Jong-hyun Lee ) , 장재기 ( Jae Ki Chang ) , 이정훈 ( Lee Jeonghoon ) , 안효진 ( Hyo-jin An )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 6호 발행 연도 : 2020 페이지 : pp. 11-19 (9 pages)

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Objective : The genus Glycyrrhiza has been used in food and traditional herbal medicine. Glycyrrhiza new varieties Wongam and Sinwongam have been developed by Korea Rural Development Administration and investigated to register on Korean Pharmacopoeia of the Ministry of Food and Drug Safety. The aim of this study is to investigate the immunomodulatory effect of Wongam and Sinwongam comparing with listed Glycyrrhiza species (Glycyrrhiza uralensis Fischer and G. glabra Linne) for evaluations about pharmacological effect of Glycyrrhiza new varieties.
Methods : We studied the immunomodulatory effect of Wongam and Sinwongam compared with G. uralensis and G. glabra using THP-1 cell in vitro model. The cells were treated with phorbol 12-myristate 13-acetate (PMA) for differentiation and stimulated with lipopolysaccharides (LPS) to induce immune activation. We analyzed and compared the effects Glycyrrhiza new varieties and listed Glycyrrhiza species using nitric oxide (NO) assay, western blot, and reverse transcription-quantitative polymerase chain reaction analysis.
Results : Wongam and Sinwongam showed no cytotoxicity in THP-1 cells. Wongam and Sinwongam, and listed Glycyrrhiza species increased NO production, and cyclooxygenase (COX)-2 expression with or without LPS in differentiated THP-1 macrophages. Furthermore, Wongam and Sinwongam and listed Glycyrrhiza species upregulated the mRNA expressions of T helper type 1 (Th 1)-associated cytokines in LPS-stimulated THP-1 macrophages.
Conclusion : These results indicated that Wongam and Sinwongam would have effect of enhancing immune response through the increase of NO and COX-2 expression, and activate Th1-associated cytokines. The findings of this study suggest the wide applicability of Glycyrrhiza new varieties.

KCI등재

3DSS로 궤양성 대장염 유발된 동물모델에서 의이아(薏苡芽) 열수 추출물의 개선 효과

저자 : 김민주 ( Min Ju Kim ) , 신미래 ( Mi-rae Shin ) , 이진아 ( Jin A Lee ) , 박순애 ( Soon-ae Park ) , 박해진 ( Hae-jin Park ) , 이정훈 ( Jeong Hoon Lee ) , 노성수 ( Seong-soo Roh )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 6호 발행 연도 : 2020 페이지 : pp. 21-28 (8 pages)

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Objectives:The objective of this study was to investigate the improvement effect of Sprout of Coix lacryma-jobi var. mayuen Stapf water extract (SC) on the dextran sulfate sodium (DSS)-induced ulcerative colitis mice.
Methods:The antioxidant activity of SC was measured through total polyphenol and total flavonoid content in vitro. The experiment was conducted with seven-week-old male Balb/c mice. After 1 week adaptation, acute colitis was induced by oral administration of 5% DSS dissolved in drinking water, for 7 days. And normal mice received drinking water without DSS throughout the entire experimental period. For each experiment, the mice were divided into 4 groups and 24 colitis mice were arbitrarily allocated into 3 groups (n = 8/group); Normal group, Control group, SC 100 ㎎/㎏ treated group (SCL), SC 200 ㎎/㎏ treated group (SCH). Serum and colon tissues were collected after one weeks of drug administration.
Results:ROS levels, ONOO- levels, AST, and ALT in serum were decreased in SC treated groups compared to the control group. Western blotting measurements of Nrf2, HO-1, SOD, catalase, GPx-1/2, IL-4, IL-10, and Bcl2 showed that the SC treated groups was increased compared to the Control group. Also, western blot measurements of NFĸBp65, p-IĸBα, COX-2, iNOS, TNF-α, IL-1β, Bax, and Caspase-3 showed that the SC treated groups was reduced compared to the Control group.
Conclusion:Taken together, these results suggest that SC treatment can attenuate the DSS-induced colitis though inhibiting NF-ĸB pathway and enhancing Nrf2 pathway. Therefore, SC was the potential to be used as a natural therapeutic drug.

KCI등재

4계지감초용골모려탕(桂枝甘草龍骨牡蠣湯)이 치오펜탈 나트륨으로 유도된 수면의 입면 및 수면 시간에 미치는 영향

저자 : 김태연 ( Tae Yeon Kim ) , 임강현 ( Kanghyun Leem )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 6호 발행 연도 : 2020 페이지 : pp. 29-34 (6 pages)

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Objectives : Gyejigamchoyonggolmoryeo-tang (GT, Guizhigancaolonggumulitang in Chinese) is a herbal medicine to be prescribed for insomnia caused by anxiety induced by Heart-Heat and elevated Liver-Yang. In the present study, the onset time (sleep latency) and the duration time of sleep were measured to find out the sleep inducing effects of GT. The expression of c-fos immunohistochemistry was also measured at the ventrolateral preoptic area (VLPO) and tuberomammillary nucleus (TMN) site in brain.
Methods : The onset time (sleep latency) and the duration time of sleep were measured 30 minutes after thiopental sodium injection. Thereafter, brain tissue was obtained and c-fos immunohistochemistry was performed on the VLPO and TMN sites.
Results : GT statistically significantly reduced the sleep latency required to enter sleep, and significantly increased sleep duration time. GT significantly increased the number of c-fos immunohistochemical staining-positive cells in the sleep-inducing center (VLPO), whereas GT significantly decreased the number of c-fos immunohistochemical staining-positive cells in the arousal center (TMN).
Conclusions : It could be concluded that the GT shortened the sleep latency and increased the duration time for sleep induced by thiopental sodium. And it was confirmed that the mechanism was to stimulate the sleep-inducing center (VLPO) and suppress the arousal center (TMN) in the brain. The results of this study are considered to be useful as scientific evidence that can be used clinically for the treatment of insomnia caused by anxiety.

KCI등재

5비소세포 폐암 세포 (NCI-H520) 이식 마우스에서 포모사 자두 추출물의 면역활성 및 악액질 억제효과

저자 : 손영숙 ( Young-sook Son ) , 이상남 ( Sang-nam Lee ) , 박지하 ( Ji-ha Park )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 6호 발행 연도 : 2020 페이지 : pp. 35-41 (7 pages)

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Objectives : The object of this study was to observe anticancer and immunomodulatory effects of Formosa plum aqueous extracts (PLe) on non-small cell lung carcinoma (squamous epithelial carcinoma), NCI-H520, xenograft Balb/c nu-nu nude mice.
Method : Three different dosages of PLe, 50, 100 and 200 ㎎/㎏ were orally administered once a day for 28 days from 11 days after tumor cell inoculation. Five groups, each of seven mice per group were used in the present study as follows. Tumor volume and weights, serum interferon (IFN)-γ levels, serum IL-6 were observed with tumor mass and lymphatic organ histopathology to detect anticancer and immunomodulatory effects.
Result : Although no meaningful changes on the tumor weights and volumes were observed after treatment of all three different dosages of PLe, decreases of tumor cell volumes in tumor masses were dose-dependently decreased mediated by increases of apoptosis among tumor cells by treatment of PLe 100 and 200 ㎎/㎏ as compared with tumor-bearing control. In addition, decreases on the body weight and gains were also demonstrated in tumor-bearing control with increases of serum IL-6 levels.
Conclusion : The results obtained in this study suggest that over 50 ㎎/㎏ of PLe showed favorable immunomodulatory and anticachexic effects with anticancer effects in 100 and 200 ㎎/㎏ of PLe treated groups on the NCI-H520 cell xenograft. However, detail mechanism studies should be conducted in future with the screening of the biological active compounds in this herb.

KCI등재

6대황(大黃)과 황금(黃芩) 추출물 혼합물이 급성 역류성 식도염 흰쥐에 미치는 효과

저자 : 이진아 ( Jin A Lee ) , 신미래 ( Mi-rae Shin ) , 이상남 ( Sang-nam Lee ) , 박순애 ( Soon-ae Park ) , 박해진 ( Hae-jin Park )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 6호 발행 연도 : 2020 페이지 : pp. 43-53 (11 pages)

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Objective : Reflux esophagitis is a disease caused by reflux of stomach contents, stomach acid, and pepsin into the esophagus, and is currently increasing worldwide. This study was conducted to evaluate the effect of a mixture of Rhei Rhizoma and Scutellariae Radix (RS) extract on acute reflux esophagitis in rats.
Methods : Rats were divided into five groups for examination: Normal group (Nor, n=8), water-treated acute reflux esophagitis rats (Con, n=8), tocopherol 30 ㎎/㎏ body weight/day-treated acute reflux esophagitis rats (Toco, n=8), RS 100 ㎎/㎏ body weight/day-treated acute reflux esophagitis rats (RS100, n=8), RS 200 ㎎/㎏ body weight/day-treated acute reflux esophagitis rats (RS200, n=8). All rats fasted for 18 h and then were derived by linking the metastatic junction between pylorus and forestomach and corpus. And rats were sacrificed 5 h after surgery. We analyzed the expression of NADPH, MAPK, inflammatory, anti-inflammatory, and tight junction related proteins by western blot in esophageal tissue and observed the level of reactive oxygen species (ROS), alanine aminotransferanse (ALT), and aspartate aminotransferase (AST) in serum.
Results : RS administration significantly protected the esophageal mucosal damage of reflux esophagitis, and ROS, AST, and ALT levels were significantly reduced in RS administration compared to Con group. In addition, RS administration effectively suppressed MAPK and NF-κB pathways and upregulated protein expressions of tight junction protein.
Conclusions : These results suggest that RS protected the esophageal mucosa by inhibiting the MAPK and NF-κB pathways and upregulating tight junctions.

KCI등재

7Estradiol benzoate 및 oxytocin 투여로 유발된 랫트 생리통 모델에서 댕댕이나무 열매 농축동결건조 분말의 진통 및 생리장애 개선 효과

저자 : 주시찬 ( Si-chan Joo ) , 이상남 ( Sang-nam Lee ) , 최성훈 ( Seong-hun Choi ) , 박지하 ( Ji-ha Park )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 6호 발행 연도 : 2020 페이지 : pp. 55-68 (14 pages)

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Objectives : We observed the possibilities that blue honeysuckle has favorable analgesic or refinement effects on the Primary dysmenorrhea (PD) in rats.
Methods : Estradiol benzoate and oxytocin were used to induce the PD rat model. And Blue honeysuckle concentration lyophilized powders (BH) 500, 250 and 125 ㎎/㎏ and 500 ㎎/㎏ of Lonicerae Flos aqueous extract lyophilized powders (LF) were orally administered, once a day for 10 days at 30 min after each estradiol benzoate treatment. Then the changes on the body weights and gains during experimental periods, abdominal writhing response for analgesic activities, uterine weights, uterus lipid peroxidation, antioxidant defense system - glutathione contents, superoxide dismutase and catalase activities, NF-κB and COX-2 mRNA expressions were monitored with uterus histopathology including immunohistochemistry for tumor necrosis factor (TNF)-α and inducible nitric oxide synthase (iNOS)..
Results : Inflammatory and oxidative stress mediated PD signs were favorably and dose-dependently inhibited by 10 days continuous oral administration of three different dosages of BH - 500, 250 and 125 ㎎/㎏ as comparable to those of indomethacin(IND) 5 ㎎/㎏ treated rats in BH 500 ㎎/㎏ administered PD rats, and similar to those of LF 500 ㎎/㎏ in BH 125 ㎎/㎏, at least in a condition of the present PD rat model.
Conclusions : The results suggest that BH has favorable analgesic and refinement activities on the estradiol benzoate and oxytocin treatment-induced PD signs through anti-inflammatory and antioxidative potentials.

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1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

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(2006)홍길동심리학41회 피인용

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(2006)홍길동41회 피인용

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