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대한본초학회지(본초분과학회지) update

The Korea Jounrnal of Herbology

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수록정보
수록범위 : 1권0호(1986)~35권4호(2020) |수록논문 수 : 1,599
대한본초학회지(본초분과학회지)
35권4호(2020년 07월) 수록논문
최근 권호 논문
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KCI등재

1참당귀, 중국당귀, 일당귀의 헤모글로빈 활성도 비교

저자 : 이장천 ( Jang-cheon Lee ) , 조수인 ( Suin Cho ) , 김형우 ( Hyungwoo Kim ) , 김정훈 ( Jung-hoon Kim ) , 성대동 ( Dae Dong Sung ) , 이부균 ( Boo-kyun Lee )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 4호 발행 연도 : 2020 페이지 : pp. 1-8 (8 pages)

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Objectives : Angelicae gigas, A. sinensis and A. acutiloba are three types of plants used as Angelicae Radix (Dang-Gui). Many doctors of Korean medicine want to know the difference in clinical use of these three species. This study aimed to compare the hemoglobin-related activity of the extracts of Angelicae gigas, A. sinensis and A. acutiloba roots by measuring the intensity of binding oxygen to hemoglobin using Raman spectroscopy.
Methods : Hemoglobin activity was measured by chemical analysis and Raman spectroscopy to compare the pharmaceutical efficacy of three Angelica root extracts. The oxygenated hemoglobin intensity, blood decursinol and acetylcholinestrase(AChE) concentration in mice were measured. In addition, the effects of three Angelica root extracts on oxygenated hemoglobin intensity, decursinol and AChE concentration in red blood cells (RBC) from human were also investigated.
Results : The contents of decursin, decursinol and decursinol angelate, which affected physiological activity and RBC properties, were higher in the extract of A. gigas root than in those of A. sinensis and A. acutiloba roots. Moreover, oxygenated hemoglobin intensity in the A. gigas extract was higher than that of other two species in the blood of mice and human RBCs. Also, the blood decursinol and AChE concentrations of A. gigas root extract were higher than that of A. sinensis and A. acutiloba roots.
Conclusions : These results suggest that A. gigas is more effective in treating disease related oxygen deficiency in RBC deformation under oxidative stress.

KCI등재

2과산화수소 자극으로 활성화된 C6 성상교세포에 대한 맥문동추출물의 조절 효능 연구

저자 : 박기호 ( Ki Ho Park ) , 강석용 ( Seok Yong Kang ) , 정효원 ( Hyo Won Jung ) , 박용기 ( Yong-ki Park )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 4호 발행 연도 : 2020 페이지 : pp. 9-16 (8 pages)

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Objective : To identify the effects of the water extract of Liriope platyphylla tuber (Liriopis tuber, LT) on the activation of astocytes, we investigated the regulatory effects of LT extract on H2O2-induced oxidative damage in C6 rat astrocytes.
Methods : LT extract was extracted with boiling water. C6 cell line were treated with LT extract at 1, 2, and 3 ㎎/㎖ or without for 30 min and then stimulated with H2O2 at 5 ㎛ for 24 hr. The cell viability was measured by MTT assay. The expression of glial fibrillary acidic protein (GFAP), signal transducer and activator of transcription 3 (STAT3), phospho-STAT3 (pSTAT3), cyclooxygenase (COX-2), Nuclear factor-κB (NF-κB), superoxide dismutase 2 (SOD2), heme oxygenase-1 (HO-1), catalase, Akt, phospho-Akt (p-Akt) phosphoinositide 3-kinases (PI3K), and protein kinase C alpha (PKCα) proteins were determined by Western blot, respectively. GFAP expression was also observed with immunocytochemistry under a fluorescence microscope.
Results : LT extract induced cell proliferation in H2O2-stimulated C6 cells. LT extract significantly inhibited the expression of GFAP, NF-κB and COX-2 and increased the expression of HO-1 and the phosphorylation of STAT3 in H2O2-stimulated C6 cells. LT extract also significantly increased the phosphorylation of Akt and decreased the expression of PKCα in a dose-dependent manner in H2O2-stimulated C6 cells.
Conclusions : LT extract can regulate H2O2-induced activation of astrocytes through inhibiting the expression of NF-κB, COX-2 and regulating Akt / HO-1, STAT3 or PKCα signaling pathway.

KCI등재

3민꽃게 추출물의 역류성 식도염 동물모델에서 유효성 평가

저자 : 남현화 ( Hyeon-hwa Nam ) , 서윤수 ( Yun-soo Seo ) , 이지혜 ( Ji Hye Lee ) , 서영혜 ( Young Hye Seo ) , 양선규 ( Sungyu Yang ) , 문병철 ( Byeong Cheol Moon ) , 김욱진 ( Wook Jin Kim ) , 난리 ( Li Nan ) , 추병길 ( Byung Kil Choo ) , 김중선 ( Joong-sun Kim )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 4호 발행 연도 : 2020 페이지 : pp. 17-23 (7 pages)

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Objectives : In this study, we investigated the protective effects of Charybdis japonica (C. japonica ) water extract on the acute reflux esophagitis in rat models.
Methods : Twenty rats were divided into four groups for examination: normal control group (n=6), the reflux esophagitis group (n=6), reflux esophagitis treated with positive control group (ranitidine 40 ㎎/㎏, n=6), reflux esophagitis treated with C. japonica group (100 ㎎/㎏, n=6). All rats fasted for 18 hr and then were induced with reflux esophagitis by a pylorus and forestomach ligation operation. After 4 hr, the rats were sacrificed. The proinflammatory cytokine and proteins expression measured by western bolt assay, and the histopathological analysis of the esophageal mucosa measured by hematoxylin and eosin staining.
Results : C. japonica administration significantly was protecting esophageal mucosal damage upon histological analysis of reflux esophagitis in rats. The C. japonica treatment confirmed the protection of the reduction of claudin-5, an evaluation index of the damage of tight junctions in the reflux esophagitis. C. japonica was also found to inhibit the expression of proteins such as COX-2 and TNF-α in the rat esophagus. C. japonica markedly attenuated the activation of NF-κB and phosphorylation of IκBα at the same time.
Conclusion : These results indicated that C. japonica suppressed the development of esophagitis through the modulation of inflammation by regulating NF-κB activation. Based on these findings, we concluded that C. japonica can prevent reflux esophagitis.1

KCI등재

4만성 역류성 식도염 동물 모델에 대한 황백(黃柏) 물 추출물의 식도 점막 보호 효과

저자 : 이세희 ( Se Hui Lee ) , 이진아 ( Jin A Lee ) , 신미래 ( Mi-rae Shin ) , 이지혜 ( Ji Hye Lee ) , 노성수 ( Seong-soo Roh )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 4호 발행 연도 : 2020 페이지 : pp. 25-36 (12 pages)

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Objective : Reflux esophagitis is a disease caused by the reflux of gastric acid and inflammation due to unstable gastroesophageal sphincter. The aim of the present study was to clarify the effect of Phellodendri Cortex (PC) on chronic reflux esophagitis (CRE) in rats.
Methods : The anti-oxidant activity of PC was measured by total polyphenol, total flavonoid contents, 1, 1-diphenyl- 2-picrylhydrazyl (DPPH), and 2, 2'-azinobis-3-ethyl-enzothiazoline-6-sulfonic acid (ABTS) radical scavenging activity. A CRE was established surgically in SD rats. And then CRE rats were treated with water or PC 200 ㎎/㎏ body weight for 14 days. Besides, the anti-oxidant and inflammatory protein levels were evaluated using western blotting.
Results : PC reduced esophagus tissues injury. The total polyphenol (36.05 ± 0.25 ㎎/g) and total flavonoid (72.90 ± 0.61 ㎎/g) of PC showed a high content. PC strongly reduced radical scavenging activities (DPPH IC50 43.58 ± 1.54 ㎍/㎖; ABTS IC50 36.75 ± 0.35 ㎍/㎖).
Moreover, reactive oxygen species (ROS) and peroxynitrite (ONOO-) levels in serum, the protein expression of inducible nitric oxide synthases (iNOS) were significantly reduced. In addition, the protein expression of NADPH oxidases related to oxidative stress were significantly reduced in PC compared to CRE control.
PC effectively reduced inflammatory factors including, TNF-α, and IL-6 via NF-κBp65 inactivation through the inhibition of p-IκBα and increased anti-oxidant enzyme such as HO-1, SOD, catalase, and GPx-1/2 via Nrf2 activation.
Conclusions : Taken together, these results show that PC can alleviate the esophageal mucosal ulcer though the inhibition of NF-κB inflammatory and the enhancement of Nrf2 anti-oxidant pathway.

KCI등재

5삼채(三菜) 물추출물이 RAW 264.7 세포의 항산화 및 염증반응에 미치는 영향

저자 : 이상수 ( Sangsoo Lee ) , 한효상 ( Hyosang Han ) , 유자연 ( Jayeon Yoo ) , 남명수 ( Myung Soo Nam ) , 김기광 ( Keekwang Kim )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 4호 발행 연도 : 2020 페이지 : pp. 37-43 (7 pages)

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Objectives : Allium hookeri is a well-known traditional herbal remedy and its root used for treatment of inflammation and tumor. However, the mechanism of anti-inflammatory effect of Allium hookeri is still unknown. This study aims to examine the mechanism of anti-inflammatory effect of Allium hookeri on mouse macrophage cell line, RAW 264.7 cells.
Methods : Anti-oxidant effect of water extract of Allium hookeri (WEAH) was measured by 2,2'-azino-bis-3- ethylbenzothiazoline-6-sulphonic acid (ABTS) assay. 3- (4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)- 2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay was performed to determine the effect of WEAH on cell viability in RAW 264.7 cells. In addition, anti-inflammatory effect of WEAH was investigated in RAW 264.7 cells. Inflammation of RAW 264.7 cells induced by lipopolysarccharide (LPS) treatment and expression levels of inflammatory cytokine interleukin 1 β (IL-1β) and interleukin 6 (IL-6) gene were analyzed using quantitative reverse transcription PCR (qRT-PCR) analysis. Furthermore, the phosphorylation of inhibitor of nuclear factor kappa B (IκBα) after LPS treatment with WEAH-treated RAW 264.7 cells was confirmed by immunoblot analysis.
Results : WEAH showed a strong anti-oxidant effect and no cytotoxicity to RAW 264.7 cells up to 2 ㎎/㎖concentration. The LPS-induced mRNA expression levels of IL-1β and IL-6 were decreased by WEAH treatment. Furthermore, the LPS-induced phosphorylation of IκBα is attenuated by WEAH treatment.
Conclusions : Through experimental demonstration of anti-oxidant and anti-inflammatory effects of WEAH, we suggest that Allium hookeri is a valuable material for prevention and treatment of various inflammatory diseases.

KCI등재

6복분자 추출물의 Sprague-Dawley rat를 이용한 단회 경구 투여 독성시험

저자 : 이주영 ( Joo Young Lee ) , 지건영 ( Kon-young Ji ) , 송광훈 ( Kwang Hoon Song )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 4호 발행 연도 : 2020 페이지 : pp. 45-50 (6 pages)

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Objective : This study was performed to evaluate the toxicity after a single oral administration of black raspberry extract to male and female Sprague-Dawley (SD) rats and to determine the approximate lethal dose (ALD).
Methods : We previously showed that the black raspberry extract repressed the simvastatin-mediated expression of Proprotein convertase subtilisin/kexin type 9 (PCSK9) and improved Low-Density Lipoprotein cholesterol (LDL-C) uptake by hepatocytes through the induction of the Low-Density Lipoprotein Receptor expression in hepatocytes. The groups consisted of black raspberry extract groups, as an oral dose of 2,000 ㎎/㎏ and a control group. 5 weeks SD rats were randomly assigned to 4 groups of 5 rats. Each male and female SD rats were administered orally once. For 14 days after the administration, mortality, clinical signs, changes in body weight, and necropsy findings were observed according to the “Standard for Toxicity Study of Pharmaceuticals” of Korea Food and Drug Administration (KFDA) guideline and “Acute Oral Toxicity- Fixed Dose Procedure” of OECD Test Guideline.
Results : There were no cases of mortality in the group administered with 2,000 ㎎/㎏ of male and female, and no abnormalities in body weight change and clinical signs. Also, no gross abnormalities were observed at the autopsy.
Conclusions : As a result of a single oral administration of the black raspberry extract to SD rats, the ALD was determined to exceed 2,000 ㎎/㎏ for both male and female SD rats.

KCI등재

7도인(桃仁)의 아토피 피부염 모델 피부조직 및 혈청 내 염증매개물질 조절 효과

저자 : 김상우 ( Sangwoo Kim ) , 홍수연 ( Sooyeon Hong ) , 권보근 ( Boguen Kwon ) , 김명현 ( Myunghyun Kim ) , 김상배 ( Sang-bae Kim ) , 진대환 ( Dae-hwan Jin ) , 최우찬 ( Woochan Choi ) , 손영주 ( Youngjoo Sohn ) , 정혁상 ( Hyuk-sang Jung )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 35권 4호 발행 연도 : 2020 페이지 : pp. 51-60 (10 pages)

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Objective : The objective of this study was to demonstrate the effect of Persicae Semen (PS) in DNCB-induced atopic dermatitis mouse and HaCaT cell.
Methods : The BALB/c mice were divided into four groups. To develop atopic dermatitis, 200 ㎕ of 1 and 0.5% DNCB solution was put on the back of mice in the Control group, the PS-Low group and the PS-High group once a day. After application of DNCB, 200 ㎕ of the PS extract was also treated. The Normal group was given PBS. The mice dorsal skin was stained with Masson's trichrome, H&E, and toluidine blue to evaluate the thickness of the epidermis and dermis, infiltration of eosinophils and mast cells respectively. ELISA was applied to measure the serum level of IgE and IL-6. Toxicity of PS was measured by MTS assay in HaCaT cell. To investigate the effects of PS on HaCaT cells, cells were pre-treated with PS for 1h, and then stimulated with TNF-α and IFN-γ. After 24 hours, the expression of TARC was analyzed using RT-PCR.
Results : PS not only significantly diminished the thickness of the epidermis and dermis, but also reduced the infiltration of eosinophil and mast cell in skin lesion. PS also reduced the serum IgE and IL-6 level which plated important roles in the atopic dermatitis. The expression of TARC was decreased significantly in TNF-α/IFN-γ stimulated HaCaT cell.
Conclusion : These results suggest that PS may be effective in alleviating the atopic dermatitis induced by DNCB and inflammation by TNF-α/IFN-γ.

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1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

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(2006)홍길동41회 피인용

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