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대한한방부인과학회지 update

The Journal Of Oriental Gynecology

  • : 대한한방부인과학회
  • : 의약학분야  >  기초한의학
  • : KCI등재
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  • : 연속간행물
  • : 계간
  • : 1229-4292
  • : 2508-3619
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수록정보
수록범위 : 1권1호(1987)~33권3호(2020) |수록논문 수 : 1,196
대한한방부인과학회지
33권3호(2020년 08월) 수록논문
최근 권호 논문
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KCI등재

1여성 과민성 방광 전침 치료의 무작위 대조군 연구에 관한 체계적 문헌 고찰

저자 : 하수진 ( Su-jin Ha ) , 황덕상 ( Deok-sang Hwang ) , 이진무 ( Jin-moo Lee ) , 이창훈 ( Chang-hoon Lee ) , 장준복 ( Jun-bock Jang )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 33권 3호 발행 연도 : 2020 페이지 : pp. 1-19 (19 pages)

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Objectives: The purpose of this study is to assess the efficacy and safety of electroacupuncture for women with overactive bladder (OAB) comparing with sham- acupuncture, and electroacupuncture plus drugs.
Methods: We searched 8 databases upto May 26, 2020. Randomised controlled trials (RCTs) were eligible. The risk of bias was assessed by two independent authors using the Cochrane risk of bias tool. Study outcomes were calculated by standardized mean differences (SMD) with 95% confidence intervals (Cls) and mean differences (MD) with 95% Cls.
Results: Of 146 screened, 5 RCTs were included. Number of participants per study ranged from 5 to 57. The combined results showed that electroacupuncture (EA) may be more effective than sham acupuncture or enhance solifenacin succinates in improving Overactive Bladder Symptom Score (OABSS) and urination frequency of 24 h. However, more trials with high quality and larger sample sizes will be needed to provide sufficient evidence. Only 5 of 187 OAB patients from the included studies reported mild adverse reactions related to EA, therefore, electroacupuncture is safe for treating OAB.
Conclusions: Electroacupuncture might have effect in decreasing urination frequency of 24 h and OABSS. However, the evidences ins in sufficient to show the effect using electroacupuncture alone or additional effect to drugs in treating OAB.

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2조기난소부전의 한의학적 치료에 대한 국내 연구 동향 고찰

저자 : 김민경 ( Min-kyung Kim ) , 김순아 ( Suna Kim ) , 김수진 ( Su-jin Kim ) , 정우진 ( Wu-jin Jeong ) , 허효승 ( Hyo-seung Huh ) , 김혜경 ( Hye-gyeong Kim )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 33권 3호 발행 연도 : 2020 페이지 : pp. 20-39 (20 pages)

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Objectives: This study was performed to examine the domestic study trends on premature ovarian failure (POF) treated with Korean medicine.
Methods: We investigated the studies on Korean medicine treatment for premature ovarian failure via searching 4 online databases.
Results: 13 clinical studies were selected. All studies were the noncomparative studies, and mainly case reports. Studies were publicated from 2001 to 2019 and the number of studies with 1 subject was the greatest (76.9%). In accompanying symptoms, there was a study which did not report entire cases. In the 11 case reports (13 subjects), the most accompanying symptoms was hot flush (69.2%). In treatment of premature ovarian failure, the most used treatment was herbal medicine, which was used in all studies. Acupuncture treatment was used in 6 studies (46.2%) and moxibustion treatment was used in 8 studies (61.5%). The most common acupuncture point was 內關 (SP6) in acupuncture treatment, and was 關元 (CV4) in moxibustion treatment. The duration of treatment was between 1 month and 20 months, the average 7.76 months. Used outcome measurements were hormone test (84.6%), menstruation (76.9%), Visual analog sclale (VAS) (15.4%), ultrasonography (15.4%), Numeral rating scale (NRS), Body basal temperature (BBT) and Kupperman index (7.7%). In total 70 subjects, 13 subjects (18.6%) became pregnancy and 25 subjects (35.7%) had no effect. Follow up was reported in 6 studies, and the average duration of follow up was 141.63 days.
Conclusions: Further clinical trials are needed to establish the evidence for Korean Medicine treatment for premature ovarian failure.

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3연교(連翹)와 금은화(金銀花) 에탄올 추출물의 항염증 효능 연구

저자 : 류효경 ( Hyo-kyung Ryu ) , 정민재 ( Min-jae Jung ) , 최유진 ( Yu-jin Choi ) , 양승정 ( Seung-jeong Yang ) , 조성희 ( Seong-hee Cho )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 33권 3호 발행 연도 : 2020 페이지 : pp. 40-59 (20 pages)

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Objectives: The purpose of this study was to investigate the anti-inflammatory effects of ethanol extracts from Forsythia viridissima Lindley's fructus and Lonicera japonica Thunberg's flos in vitro, which has been frequently used in inflammatory diseases.
Methods: In this experiment, the anti-inflammatory effects of ethanol extracts from Forsythia viridissima Lindley's fructus and Lonicera japonica Thunberg's flos were evaluated by checking the following substances of LPS-activated Raw264.7 cell: Prostaglandin E2 (PGE2), Nitric oxide (NO), Cyclooxygenase-2 (COX-2), inducible Nitric oxide synthase (iNOS), Interlukine-1β (IL-1β), Interlukine-6 (IL-6), Tumor necrosis factor-α (TNF-α), mitogen-activated protein kinase (MAPK), Inhibitor of kappa B-α (IκBα), Nuclear factor kappa B (NF-κB). And additionally measured reactive oxygen species (ROS) and free radicals to check the antioxidant effect of ethanol extracts from Forsythia viridissima Lindley's fructus and Lonicera japonica Thunberg's flos which affect inflammatory responses.
Results: As a result of measuring anti-inflammatory efficacy, PGE2, NO, IL-1β, IL-6, TNF-α production amounts were reduced in the ethanol extracts from Forsythia viridissima Lindley's fructus and Lonicera japonica Thunberg's flos groups compared with the control group, and decreased the amount of COX-2 mRNA, iNOS mRNA gene expression. Expression of MAPK (ERK, JNK, p38) pathway was decreased. Expression of IκBα was increased and NF-κB was decreased. It is demonstrated that ethanol extracts from Forsythia viridissima Lindley's fructus and Lonicera japonica Thunberg's flos, by reducing NF-κB, regulate the expression of the inflammatory genes and reduce the inflammatory mediators. Ethanol extracts from Forsythia viridissima Lindley's fructus and Lonicera japonica Thunberg's flos also decreased ROS production and free radicals, which shown to have antioxidant efficacy and influence anti-inflammatory effects.
Conclusions: These data suggest that ethanol extracts from Forsythia viridissima Lindley's fructus and Lonicera japonica Thunberg's flos can be used to treat various inflammatory diseases.

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4난소과자극증후군의 치료에 관한 한의 임상 연구 고찰

저자 : 구수정 ( Su-jeong Ku ) , 황덕상 ( Deok-sang Hwang ) , 이진무 ( Jin-moo Lee ) , 이창훈 ( Chang-hoon Lee ) , 장준복 ( Jun-bock Jang )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 33권 3호 발행 연도 : 2020 페이지 : pp. 60-79 (20 pages)

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Objectives: This review plans to assess the efficacy and effectiveness of oriental medicine for the treatment of Ovarian Hyperstimulation Syndrome (OHSS) through literature research and overview.
Methods: Database searching was conducted to identify relevant randomized controlled trials (RCTs) on oriental medicine for the treatment of Ovarian Hyperstimulation Syndrome. Studies were searched from Journal of Korean Obstetrics and Gynecology, Korean Medical Database, Korean studies Information Service System, China National Knowledge Infrastructure, Cochrane library, PubMed and EmBase up to 21st May, 2020.
Results: Seventeen studies were finally selected. Fifteen studies intervened with oral Chinese herb medicine, two studies intervened with acupuncture and moxibustion. Nine studies concluded that intervention with oriental medicine significantly relieved OHSS symptoms. Three studies reporting ovary diameter, four studies reporting abdominal circumference and other four studies reporting pelvic effusion showed significant reduction compared to control groups. Six studies showed significantly shorter duration for hospitalization in intervention groups. Only one study showed significantly higher pregnancy rate. Factors related with vascular permeability and blood cell coagulation were significantly lowered in intervention groups in general.
Conclusions: From seventeen studies, oriental medicine relieved OHSS symptoms and showed treatment effectiveness. Further strictly designed studies and long-term observed studies are needed to establish evidences.

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5한방여성의학 영역에서 진단 도구로 적외선 체열 검사 (Digital Infrared Thermal Imaging, DITI)를 활용한 국내 연구 동향 분석

저자 : 임지영 ( Ji-yeong Im ) , 황덕상 ( Deok-sang Hwang ) , 이진무 ( Jin-moo Lee ) , 이창훈 ( Chang-hoon Lee ) , 장준복 ( Jun-bock Jang )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 33권 3호 발행 연도 : 2020 페이지 : pp. 80-94 (15 pages)

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Objectives: The purpose of this review is to analyze the domestic study trends of clinical use of Digital Infrared Thermal Imaging (DITI) as a diagnosis instrument on obstetrics and gynecological diseases in Korean literature.
Methods: We searched for clinical studies using DITI in the journal of Korean obstetrics & gynecology, National Digital Science Library, Research Information Sharing Service, Korean Medical Database up to May 2020. After searching studies, we selected studies and analyzed according to disease.
Results: 18 clinical studies were published in two kinds of academic journals. There were 4 studies about dysmenorrhea and menopausal symptoms, 2 studies about postpartum disease and hypercryalgesia, 1 study about amenorrhea, premenstrual syndrome, leukorrhea, infertility, polycystic ovary syndrome and hot flush. Conception vessel was frequently used for DITI measurement, followed by stomach meridian. The temperatures of abdomen (CV4, CV12), face (HN3), upper and lower limb (PC8, LU4, LR3, ST32) were commonly measured.
Conclusions: This study shows that DITI could be one of effective diagnosis instrument for obstetrics and gynecological diseases. More well-designed clinical studies using DITI will be needed.

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6원발성 월경통에 대한 계지복령환(桂枝茯苓丸) 열수 추출물의 진통 효과

저자 : 조수연 ( Su-yun Cho ) , 김동철 ( Dong-chul Kim )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 33권 3호 발행 연도 : 2020 페이지 : pp. 95-118 (24 pages)

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목 적: 이 생체 내 연구의 목적은 인도메타신과 비교했을 때 쥐의 원발성 월경통에 대한 계지 복령환 열수 추출물의 진통 및 개선 효과를 관찰하는 것이다.
방 법: 랫트 PD 모델을 만들기 위해, Estradiol benzoate를 10일간 투여한 다음 마지막 10회 estradiol benzoate 투여 1시간 후 1U/kg의 oxytocin을 투여하였다. 계지복령환 열수 추출물을 500, 250 및 125mg/kg 용량으로 매일 1회씩 10일간 투여하였다. 이후 체중 및 실험 기간 동안의 체중 증가량, 자궁 중량 및 육안부검 소견, 진통 활성을 나타내는 abdominal writhing test, 자궁 조직 내 지질 과산화 (Malondialdehyde, MDA 함량) 및 항산화 방어 시스템 - glutathione (GSH) 함량, superoxide dismutase(SOD) 및 catalase (CAT) 활성, Nuclear factor-κB (NF-κB) 및 cyclooxygenase (COX)-2mRNA의 발현, 자궁의 조직병리학적 변화, tumor necrosis factor(TNF)-α 및 inducible nitric oxide synthase(iNOS)로 나타나는 면역조직 화학적 변화를 관찰하였다. 계지복령환 열수 추출물의 결과는 인도메타신 투여 쥐의 결과와 비교하였다.
결 과: Estradiol benzoate 및 oxytocin 투여 결과, 현저한 체중 및 증체량, 자궁 GSH 함량, SOD와 CAT 활성의 감소와 abdominal writhing 반응, 자궁 지질 과산화(MDA 함량), 자궁 중량, NF-κB 및 COX-2 mRNA 발현의 증가가 TNF-α 및 iNOS 면역반응세포와 염증세포 침윤 증가, 자궁의 충혈 및 확대와 함께 관찰되었다. 이는 전형적인 염증 및 산화 스트레스성 원발성 월경통이 잘 유도되었음을 의미한다. 한편 이러한 소견은 계지복령환 열수 추출물의 투여에 의해 용량의존적으로 현저히 억제되었으며, 인도메타신의 억제 효과보다는 낮았다.
결 론: 이 연구에서 얻은 결과는 계지복령환 열수 추출물이 estradiol benzoate 및 oxytocin으로 유도된 원발성 월경통에 용량-의존적으로 유리한 진통 및 개선 활성을 가짐을 시사한다.


Objectives: The objective of this in vivo study is to observe the analgesic effects or improvements Gyejibokryeong-hwan aqueous extracts (GJBRHe) on the Primary dysmenorrhea (PD) in rats as compared to those of Indomethacin (IND).
Methods:The rats were administered with estradiol benzoate for 10 days and oxytocin 1 hour after the last 10th administration of estradiol benzoate to make the primary dysmenorrhea rat model. Gyejibokryeong-hwa aqueous extracts 500, 250 and 125 mg/kg were orally administrated, for 10 days once a day. Then the changes on the body weights and gains during experimental periods, uterine weights and gross inspections, abdominal writhing response for analgesic activities, uterus lipid peroxidation (malondialdehyde (MDA) levels), antioxidant defense system - glutathione (GSH) contents, activities of superoxide dismutase (SOD) and catalase (CAT), Nuclear factor-κB (NF-κB) and Cyclooxygenase (COX)-2 mRNA expressions, were monitored with uterus histopathology and immunohistochemistry for tumor necrosis factor (TNF)-a and inducible nitric oxide synthase (iNOS). The results of aqueous extracts were compared to those of Indomethacin adminstered rats.
Results:As results of estradiol benzoate and oxytocin treatment, noticeable decreases of body weights and gains, uterus GSH contents, SOD and CAT activities, increases of abdominal writhing responses, uterus lipid peroxidation (MDA level), uterus weights, NF-κB and COX-2 mRNA expressions were observed with increases of TNF-α and iNOS immunolabeled cells, inflammatory cell infiltrations, congestion and enlargement of the uterus at gross and histopathological inspections. These means classic inflammatory and oxidative stress mediated primary dysmenorrhea are relatively well induced. However, these signs were favorably, and dose-dependently inhibited by administration of three different dosages of aqueous extracts, but lesser than those of Indomethacin.
Conclusions: The results obtained in this study suggest that aqueous extracts has favorable analgesic and refinement activities dose-dependently on the estradiol benzoate and oxytocin treatment-induced primary dysmenorrhea signs.

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7임신성 고혈압의 한약 치료에 대한 무작위 대조군 연구의 문헌고찰

저자 : 황수인 ( Su-in Hwang ) , 윤영진 ( Young-jin Yoon ) , 박장경 ( Jang-kyung Park )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 33권 3호 발행 연도 : 2020 페이지 : pp. 119-135 (17 pages)

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Objectives : The purpose of this study is to confirm the effectiveness and safety of herbal medicine treatment for treating pregnancy-induced hypertension.
Methods:We searched for randomized controlled trials of pregnancy-induced hypertension treated with herbal medicine, through nine databases. Interventions and results of the selected clinical studies were analyzed.
Results:Eleven randomized controlled trials were finally included according to the inclusion and exclusion criteria. Treatment group was treated with herbal medicine alone in two studies, and with herbal medicine and western medicine in nine studies. Control group was treated with western medicine. Ramulus (桑寄生) (54.5%) was the most frequently used herb in herbal medicine treatment. In all of eleven studies, treatment group was more effective for pregnancy-induced hypertension than the control group.
Conclusions : This study suggested that herbal medicine treatment alone or combined with western medicine treatment could be helpful in improving the therapeutic effect on pregnancy-induced hypertension and reducing side effects as well. However, in order to obtain stronger evidence of herbal medicine treatment for pregnancy-induced hypertension, more high-quality and well-designed randomized controlled trials should be conducted.

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8갱년기 발한과다를 호소하며 일개 한방병원에 입원한 환자 21명에 대한 치료 분석

저자 : 이혜정 ( Hye-jung Lee ) , 이수정 ( Su-jeong Lee ) , 황덕상 ( Deok-sang Hwang ) , 이창훈 ( Chang-hoon Lee ) , 장준복 ( Jun-bock Jang ) , 이진무 ( Jin-moo Lee )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 33권 3호 발행 연도 : 2020 페이지 : pp. 136-148 (13 pages)

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Objectives : Hot flush and sweating is the most of common symptoms and the main cause of treatment in Menopause. This study aims to report the therapeutic effect of Korean medicine for menopausal sweating by analysis for the patients hospitalized in a Korean Medicine Hospital.
Methods:To analyze treatment of menopausal sweating, we studied 21 patients complaining of menopausal sweating hospitalized in Kyung Hee University Hospital at Gangdong from 1st January 2015 to 31th May 2020 with retrospective chart review.
Results:All 21 subjects are treated by acupuncture, moxibustion and cupping therapy during hospitalization for an average of 11.3+9.14 days. The most common used korean herbal medicine was Gwibi-tang-gagambang, Soyo-san-gagambang, and Dangwiyukhwang-tang-gagambang, every 6 case (20%), followed by with 2 cases (6.7%). The improvement rate averaged 56.4% for daytime sweating and 53.6% for night sweating.
Conclusions: The results suggest that menopausal sweating could improve by treatment of korean medicine, confirming significant treatment effects.

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9온경탕이 족부냉증에 미치는 영향에 대한 다기관 이중맹검 무작위 대조군 연구

저자 : 권나연 ( Na-yoen Kwon ) , 유준상 ( Joon-sang Yoo ) , 김형준 ( Hyeong-jun Kim ) , 이동녕 ( Dong Nyung Lee )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 33권 3호 발행 연도 : 2020 페이지 : pp. 149-174 (26 pages)

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Objectives:This study was aimed to figure out the effect of (OKT) on cold hypersensitivity on feet in female patients.
Methods:This study was designed to implement multi-center randomized clinical trial in three Korean medical hospitals. The female patients who were enrolled in this study were 112 women who suffered from cold hypersensitivity on feet. They were randomly allocated into OKT group or control group in 11 ratio. The primary outcome was change in score of visual analogue scale of hypersensitivity on feet, and the secondary outcomes were thermometer of LU4, PC8, ST32, LR3, visual analogue scale of hypersensitivity on hands, result of cold stress test, and score of World Health Organization Quality of Life-BREF.
Results:In both group, the VAS of hypersensitivity on feet and hands was decreased while taking the medicine, and the effect of decreasing the VAS continues for the 4 weeks after the end of medication (p<0.001, 0.03, 0.001). In OKT group, the body temperature difference in lower extremity (ST32-LR3) was steadily decreased at every visit and it was statistically significant(p = 0.003, <0.001). On the other hand, in control group, the body temperature difference in lower extremity was decreased only while taking the medicine (p〈0.001).
Conclusions: OKT significantly reduced discomfort coldness on feet in patients, and the effect of treatment was maintained at least for four weeks after medication.

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10조경종옥탕가미방으로 호전된 다낭성난소증후군에 의한 희발월경 환자 증례 보고

저자 : 김민욱 ( Min-wook Kim ) , 김보리 ( Bo-ri Kim ) , 감은영 ( Eun-young Kam ) , 양승정 ( Seung-jeong Yang ) , 조성희 ( Seong-hee Cho )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 33권 3호 발행 연도 : 2020 페이지 : pp. 175-186 (12 pages)

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Objectives: The purpose of this study is to report the effect of Jokyeongjongok -tang-gami in case of oligomenorrhea patients classified with gan-ulgiche and eumheo due to polycystic ovary syndrome.
Methods: Three patients suffering from oligomenorrhea due to polycystic ovary syndrome were treated with korean medical treatment (herbal medicine, moxibustion, acupuncture) more than 3 months. The patients classified with gan-ulgiche and eumheo were treated with Jokyeongjongok-tang-gami.
Results: Three oligomenorrhea patients recovered normal menstrual cycle more than 3 times after taking Korean medical treatment for 3~6 months.
Conclusions: This 3 cases classified with gan-ulgiche and eumheo show Jokyeongjongok -tang-gami is effective on patients with rare menstruation due to polycystic ovary syndrome.

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1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

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(2006)홍길동심리학41회 피인용

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2미국의 비트코인 규제

(2006)홍길동41회 피인용

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