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한국질량분석학회> Mass Spectrometry Letters

Mass Spectrometry Letters update

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수록정보
수록범위 : 1권1호(2010)~11권3호(2020) |수록논문 수 : 209
Mass Spectrometry Letters
11권3호(2020년 09월) 수록논문
최근 권호 논문
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KCI등재 SCOPUS

1Mass Spectrometry Imaging of Microbes

저자 : Hyojik Yang , David R Goodlett , Robert K Ernst , Alison J Scott

발행기관 : 한국질량분석학회 간행물 : Mass Spectrometry Letters 11권 3호 발행 연도 : 2020 페이지 : pp. 41-51 (11 pages)

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Microbes influence many aspects of human life from the environment to health, yet evaluating their biological processes at the chemical level can be problematic. Mass spectrometry imaging (MSI) enables direct evaluation of microbial chemical processes at the atomic to molecular levels without destruction of valuable two-dimensional information. MSI is a label-free method that allows multiplex spatiotemporal visualization of atomic- or molecular-level information of microbial and microberelated samples. As a result, microbial MSI has become an important field for both mass spectrometrists and microbiologists. In this review, basic techniques for microbial MSI, such as ionization methods and analyzers, are explored. In addition, we discuss practical applications of microbial MSI and various data-processing techniques.

KCI등재 SCOPUS

2Global Histidine Phosphoproteomics in Human Prostate Cancer Cells

저자 : Yan Gao , Doeun Kim , Eunji Sung , Minjia Tan , Tae Gyun Kwon , Jun Nyung Lee , Sangkyu Lee

발행기관 : 한국질량분석학회 간행물 : Mass Spectrometry Letters 11권 3호 발행 연도 : 2020 페이지 : pp. 52-58 (7 pages)

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Histidine phosphorylation (pHis) is increasingly recognized as an important post translational modification (PTM) in regulating cellular functions in eukaryotes. In order to clarify the role of pHis in mammalian cell signaling system, a global phosphorylation study was performed in human prostate cancer cells, PC-3M, using a TiO2 affinity chromatography. A total number of 307 pHis sites were identified on the 268 proteins among total identified 9,924 phosphorylation sites on 3,316 proteins. In addition, 22 pHis proteins were classified in enzyme category. This report provides the first database for the study of pHis in prostate cancer cells.

KCI등재 SCOPUS

3Determination of Mertansine in Rat Plasma Using Liquid Chromatography-Tandem Mass Spectrometry and Pharmacokinetics of Mertansine in Rats

저자 : Won-gu Choi , Ju-hyun Kim , Hyun-joon Jang , Hye Suk Lee

발행기관 : 한국질량분석학회 간행물 : Mass Spectrometry Letters 11권 3호 발행 연도 : 2020 페이지 : pp. 59-64 (6 pages)

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Mertansine, a thiol-containing maytansinoid, is a tubulin inhibitor used as the cytotoxic component of antibody-drug conjugates for the treatment of cancer. Liquid chromatography-tandem mass spectrometry was described for the determination of mertansine in rat plasma. 50-μL rat plasma sample was pretreated with 25 μL of 20 mM tris-(2-carboxyethyl)-phosphine, a reducing reagent, and further vortex-mixing with 50 μL of 50 mM N-ethylmaleimide for 3 min resulted in the alkylation of thiol group in mertansine. Alkylation reaction was stopped by addition of 100 μL of sildenafil in acetonitrile (200 ng/mL), and following centrifugation, aliquot of the supernatant was analyzed by the selected reaction monitoring mode. The standard curve was linear over the range of 1-1000 ng/mL in rat plasma with the lower limit of quantification level at 1 ng/mL. The intra- and inter-day accuracies and coefficient variations for mertansine at four quality control concentrations were 96.7-113.1% and 2.6- 15.0%, respectively. Using this method, the pharmacokinetics of mertansine were evaluated after intravenous administration of mertansine at doses of 0.2, 0.5, and 1 mg/kg to female Sprague Dawley rats.

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