간행물

대한장연구학회> Intestinal research (Intest Res)

Intestinal research (Intest Res) update

  • : 대한장연구학회
  • : 의약학분야  >  내과학
  • : KCI등재
  • : SCOPUS
  • : 연속간행물
  • : 계간
  • : 1598-9100
  • : 2288-1956
  • :

수록정보
수록범위 : 1권1호(2003)~17권1호(2019) |수록논문 수 : 710
Intestinal research (Intest Res)
17권1호(2019년 01월) 수록논문
최근 권호 논문
| | | |

KCI등재 SCOPUS

1A new opportunity for innovative inflammatory bowel disease research: the moderate-to-severe ulcerative colitis in Korea (MOSAIK) cohort study

저자 : Chang Kyun Lee , Kang-moon Lee , Dong Il Park , Sung-ae Jung , Yoon Tae Jeen , Young Sook Park , Hyo Jong Kim

발행기관 : 대한장연구학회 간행물 : Intestinal research (Intest Res) 17권 1호 발행 연도 : 2019 페이지 : pp. 1-5 (5 pages)

다운로드

(기관인증 필요)

키워드 보기
초록보기

다운로드

(기관인증 필요)

키워드 보기
초록보기

KCI등재 SCOPUS

3Recent advance in very early-onset inflammatory bowel disease

저자 : Jung Ok Shim

발행기관 : 대한장연구학회 간행물 : Intestinal research (Intest Res) 17권 1호 발행 연도 : 2019 페이지 : pp. 9-16 (8 pages)

다운로드

(기관인증 필요)

초록보기

Recent studies on pediatric inflammatory bowel disease (IBD) have revealed that early-onset IBD has distinct phenotypic differences compared with adult-onset IBD. In particular, very early-onset IBD (VEO-IBD) differs in many aspects, including the disease type, location of the lesions, disease behavior, and genetically attributable risks. Neonatal or infantile-onset IBD develops in less than 1% of pediatric patients. Children with infantile-onset IBD have high rates of affected first-degree relatives and severe disease course. The suspicion of a monogenic cause of VEO-IBD was first confirmed by the discovery of mutations in the genes encoding the interleukin 10 (IL-10) receptors that cause impaired IL-10 signaling. Patients with such mutations typically presented with perianal fistulae, shows a poor response to medical management, and require early surgical interventions in the first year of life. To date, 60 monogenic defects have been identified in children with IBD-like phenotypes. The majority of monogenic defects presents before 6 years of age, and many present before 1 year of age. Next generation sequencing could become an important diagnostic tool in children with suspected genetic defects especially in children with VEO-IBD with severe disease phenotypes. VEO-IBD is a phenotypically and genetically distinct disease entity from adult-onset or older pediatric IBD. (Intest Res 2019;17:9-16)

KCI등재 SCOPUS

4Clinical aspects and treatments for pediatric inflammatory bowel disease

저자 : Jin Soo Moon

발행기관 : 대한장연구학회 간행물 : Intestinal research (Intest Res) 17권 1호 발행 연도 : 2019 페이지 : pp. 17-23 (7 pages)

다운로드

(기관인증 필요)

초록보기

The incidence of pediatric inflammatory bowel disease (IBD) is increasing worldwide, especially in the developing countries. It differs from adult disease in clinical manifestations, especially with regard to genetic predisposition in monogenic IBD. Pediatric disease also have a tendency to show more aggressive inflammation and greater extent of lesion. Newer drugs such as anti-tumor necrosis factor-α have been known to make a difference in treating pediatric IBD. Recent studies suggested that the patients with high risk factors might have some benefits from earlier use of biologics. To achieve treatment goals such as relieving symptoms, optimizing growth, and improving quality of life while minimizing drug toxicity, more research is needed to develop tools for risk stratification in the use of biologics for pediatric IBD. (Intest Res 2019;17:17-23)

KCI등재 SCOPUS

5Successful transition from pediatric to adult care in inflammatory bowel disease: what is the key?

저자 : Jeongseok Kim , Byong Duk Ye

발행기관 : 대한장연구학회 간행물 : Intestinal research (Intest Res) 17권 1호 발행 연도 : 2019 페이지 : pp. 24-35 (12 pages)

다운로드

(기관인증 필요)

초록보기

The incidence of pediatric-onset inflammatory bowel disease (IBD) is on the rise, accounting for up to 25% of IBD cases. Pediatric IBD often has extensive bowel involvement with aggressive and rapidly progressing behavior compared to adult IBD. Because IBD has a high morbidity rate and can have a lifelong impact, successful transition from pediatric to adult care is important to maintain the continuity of care. Furthermore, successful transition facilitates appropriate development and psychosocial well-being among patients, as well as comprehensive and harmonious healthcare delivery amongst stakeholders. However, there are various obstacles related to patients, family, providers, and organizations that interfere with successful transition. Successful transition requires a flexible and tailored plan that is made according to the patient's developmental abilities and situation. This plan should be established through periodic interviews with the patient and family and through close collaboration with other care providers. Through a stepwise approach to the transition process, patients' knowledge and self-management skills can be improved. After preparation for the transition is completed and the obstacles are overcome, patients can be gradually moved to adult care. Finally, successful transition can increase patients' adherence to therapy, maintain the appropriate health status, improve patients' self-management, and promote self-reliance among patients. (Intest Res 2019;17:24-35)

KCI등재 SCOPUS

6Current new challenges in the management of ulcerative colitis

저자 : Tomohiro Fukuda , Makoto Naganuma , Takanori Kanai

발행기관 : 대한장연구학회 간행물 : Intestinal research (Intest Res) 17권 1호 발행 연도 : 2019 페이지 : pp. 36-44 (9 pages)

다운로드

(기관인증 필요)

초록보기

Ulcerative colitis (UC) is a chronic inflammatory condition of the gastrointestinal tract. Although the cause of UC is postulated to be multifactorial in nature, including genetic predisposition, epithelial barrier defects, dysregulation of immune responses, and environmental factors, the specific pathogenesis of UC is still incompletely understood. In the treatment of UC so far, a method of suppressing immunity and treating it has been mainstream. Immunosuppressant drugs, including thiopurines (azathioprine or 6-mercaptopurine), anti-tumor necrosis factor-α (anti-TNF-α) antibody (infliximab and adalimumab), and calcineurin inhibitor, can be used in treat patients with corticosteroid-dependent and/or corticosteroid-refractory moderate-to-severe UC. Recently, in addition to such a conventional therapeutic agent, golimumab, which is the first transgenic human monoclonal anti-TNF-α antibody to be fabricated, anti α-4/β-7 integrin antibody, and Janus kinase inhibitor have been reported to novel immunosuppressant therapy. Furthermore, other treatments with unique mechanisms different from immunosuppression, have also been suggested, including fecal microbiota transplantation and Indigo naturalis, which is a Chinese herbal medicine. We compared the features and efficacy of these new treatments. In this issue, the features and treatment options for these new treatments is reviewed. (Intest Res 2019;17:36-44)

KCI등재 SCOPUS

7Improving the quality of care for inflammatory bowel disease

저자 : Byong Duk Ye , Simon Travis

발행기관 : 대한장연구학회 간행물 : Intestinal research (Intest Res) 17권 1호 발행 연도 : 2019 페이지 : pp. 45-53 (9 pages)

다운로드

(기관인증 필요)

초록보기

Great strides have been achieved in the development of quality-of-care measures and standards for inflammatory bowel disease (IBD) over the last decade. The central structural component of care in IBD revolves around the multidisciplinary team, which should be equipped with the necessary resources to operate and implement decisions. Process measures have been defined by interest groups and can be adapted into process tools for the delivery of care for various patient subgroups and clinical scenarios. The emerging treat-to-target approach to IBD management may be used to achieve optimal long-term and holistic patient-centred outcomes, such as survival, control of inflammation and disease progression, symptomatic remission, quality of life and complications. Other important quality-of-care outcome measures for IBD include disutility of care, healthcare utilization and other patient-reported outcomes such as nutritional status and impact of fistulae. The current challenge for healthcare providers and health systems is the integration of quality-of-care structures and processes into clinical practice, and the consistent delivery of updated evidence-based quality IBD care to various patient populations by individual health care providers. Finally, the awareness and appreciation for quality of care in IBD is increasing in Asia, and Asian healthcare institutions should be encouraged to take the lead in improving the quality of care in IBD. (Intest Res 2019;17:45-53)

KCI등재 SCOPUS

8Epidemiological trend in inflammatory bowel disease in Taiwan from 2001 to 2015: a nationwide population-based study

저자 : Hsu-heng Yen , Meng-tzu Weng , Chien-chih Tung , Yu-ting Wang , Yuan Ting Chang , Chin-hao Chang , Ming-jium Shieh , Jau-min Wong , Shu-chen Wei

발행기관 : 대한장연구학회 간행물 : Intestinal research (Intest Res) 17권 1호 발행 연도 : 2019 페이지 : pp. 54-62 (9 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aims: Incidences of inflammatory bowel disease (IBD), ulcerative colitis (UC), and Crohn's disease (CD), have been increasing in Asia. In this study, we report the relevant clinical characteristics and determined the epidemiological trend of IBD in Taiwan from 2001 to 2015. Methods: A retrospective study was conducted to analyze data recorded from January 2001 through December 2015 in the registered database compiled by the National Health Insurance and provided by the Ministry of Health and Welfare, Taiwan. Results: A total of 3,806 patients with catastrophic IBD illness were registered from 2001 to 2015 in Taiwan (CD, 919; UC, 2,887). The crude incidence of CD increased from 0.17/100,000 in 2001 to 0.47/100,000 in 2015, whereas that of UC increased from 0.54/100,000 in 2001 to 0.95/100,000 in 2015. The prevalence of CD increased from 0.6/100,000 in 2001 to 3.9/100,000 in 2015, whereas that of UC increased from 2.1/100,000 in 2001 to 12.8/100,000 in 2015. The male-to-female ratio in the study sample was 2.19 for CD and 1.62 for UC. The median age of those registered with CD was lower than that of those registered for UC: 38.86 and 44.86 years, respectively. A significantly greater increase in CD incidence rate was identified among 20 to 39-year-old compared with other age groups. Conclusions: Using Taiwan's nationwide insurance database, we determined that the number of patients with CD increased more rapidly during the study period than the number of patients with UC, especially among age 20 to 39-year-old, resulting in a decreased UC-to-CD ratio. (Intest Res 2019;17:54-62)

KCI등재 SCOPUS

9Hypoalbuminemia as a risk factor for thromboembolic events in inflammatory bowel disease inpatients

저자 : Marcello Rabello Imbrizi , Daniela Oliveira Magro , Tirzah De Mendonca Lopes Secundo , Marlone Cunha-silva , Paulo Gustavo Kotze , Ciro Garcia Montes , Jazon Romilson De Souza Almeida , Virginia Lucia Ribeiro Cabral

발행기관 : 대한장연구학회 간행물 : Intestinal research (Intest Res) 17권 1호 발행 연도 : 2019 페이지 : pp. 63-69 (7 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aims: Inflammatory bowel disease (IBD) are chronic entities characterized by local and systemic inflammation and may be associated with thrombosis. The aim of this study was to identify the prevalence of thromboembolic events (TEE) in hospitalized IBD patients and identify risk factors for their occurrence. Methods: This retrospective, single-center study included patients treated at a Brazilian IBD referral unit between 2004 and 2014. Patients hospitalized for more than 48 hours due to active IBD and who did not receive prophylaxis for TEE during hospitalization were included. Patients were allocated to 2 groups: those with TEE up to 30 days or at the time of hospitalization (TEE-group) and patients without TEE (control-group). Clinical and laboratory characteristics were evaluated. Results: Of 53 patients evaluated, 69,8% with Crohn's disease (CD) and 30.2% with ulcerative colitis (UC). The prevalence of TEE 30 days before or during hospitalization was 15.1%, with 10.8% in CD and 25% in UC. In the TEE group, mean serum albumin was 2.06 g/dL versus 3.30 g/dL in the control group. Patients with albumin levels below 2.95 g/dL (43.18%) had a higher risk of developing TEE (relative risk, 1.72; 95% confidence interval, 1.17-2.53) (P<0.001). Conclusions: Albumin levels were significantly lower in patients with TEE, and hypoalbuminemia was considered a risk factor for the development of TEE in this population. (Intest Res 2019;17:63-69)

KCI등재 SCOPUS

10Vitamin D deficiency is associated with disease activity in patients with Crohn's disease

저자 : Kyoung Ho Ko , You Sun Kim , Bo Kyung Lee , Jong Hyun Choi , Yong Moon Woo , Jin Young Kim , Jeong Seop Moon

발행기관 : 대한장연구학회 간행물 : Intestinal research (Intest Res) 17권 1호 발행 연도 : 2019 페이지 : pp. 70-77 (8 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aims: Previous data suggest that vitamin D has a significant role in inflammatory bowel disease (IBD). We investigated the incidence of vitamin D deficiency in Korean patients with IBD and the correlation between serum vitamin D level and disease activity. Methods: We retrospectively analyzed the medical records of patients with IBD whose serum vitamin D levels were checked. Deficiency of 25-hydroxyvitamin D was defined as <20 ng/mL. Disease activity was evaluated using the partial Mayo score for ulcerative colitis (≥2 defined as active disease) and Harvey-Bradshaw index for Crohn's disease (≥4 defined as active disease). Results: We enrolled 87 patients with IBD (ulcerative colitis [UC], 45; Crohn's disease [CD], 42). Among them, 65.5% (57/87) were men, with a mean age of 44.9±15.1 years (range, 18-75 years). The mean duration of disease was 4.7±4.8 years (range, 0.1-17.1 years). Vitamin D deficiency was found in 73.6% (64/87) of patients with IBD. Patients with IBD (mean vitamin D level, 16.3±9.0 ng/mL) showed lower vitamin D level than the healthy control group (mean vitamin D level, 20.4±7.0 ng/mL), with no statistically significant difference (P=0.136). Disease activity was inversely correlated with vitamin D deficiency in patients with CD (P=0.007). However, no correlation was observed in patients with UC (P=0.134). Conclusions: Approximately 75% of Korean patients with IBD showed vitamin D deficiency state. Vitamin D deficiency is associated with disease activity, particularly in patients with CD. (Intest Res 2019;17:70-77)

12
권호별 보기
가장 많이 인용된 논문

(자료제공: 네이버학술정보)

가장 많이 인용된 논문
| | | |
1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

다운로드

2미국의 비트코인 규제

(2006)홍길동심리학41회 피인용

다운로드

가장 많이 참고한 논문

(자료제공: 네이버학술정보)

가장 많이 참고한 논문

다운로드

2미국의 비트코인 규제

(2006)홍길동41회 피인용

다운로드

해당 간행물 관심 구독기관

국립경찰병원 백석대학교 인제대학교 순천향대학교 부산대학교
 27
 19
 19
 11
 10
  • 1 국립경찰병원 (27건)
  • 2 백석대학교 (19건)
  • 3 인제대학교 (19건)
  • 4 순천향대학교 (11건)
  • 5 부산대학교 (10건)
  • 6 연세대학교 (5건)
  • 7 목포과학대학교 (5건)
  • 8 한국방송통신대학교 (5건)
  • 9 아주대학교 (5건)
  • 10 영남대학교 (5건)

내가 찾은 최근 검색어

최근 열람 자료

맞춤 논문

보관함

내 보관함
공유한 보관함

1:1문의

닫기