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Allergy asthma & respiratory disease update

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수록정보
수록범위 : 1권1호(2013)~8권2호(2020) |수록논문 수 : 480
Allergy asthma & respiratory disease
8권2호(2020년 04월) 수록논문
최근 권호 논문
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KCI등재

1진료 현장에서 소아 마이코플라스마 폐렴을 어떻게 치료할 것인가?

저자 : 양현종 ( Hyeon-jong Yang )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 2호 발행 연도 : 2020 페이지 : pp. 51-52 (2 pages)

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2임파선내항원특이면역요법

저자 : 강성윤 ( Sung-yoon Kang ) , 정주현 ( Joo Hyun Jung ) , 이상민 ( Sang Min Lee ) , 이상표 ( Sang Pyo Lee )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 2호 발행 연도 : 2020 페이지 : pp. 53-65 (13 pages)

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Although allergen-specific immunotherapy (AIT) is a standard treatment for allergic diseases, only 5% or less of patients in whom AIT is indicated have been receiving immunotherapy because AIT needs a long-term therapeutic duration of up to 5 years. To overcome this limitation of conventional AIT, Kündig and his colleagues first introduced intralymphatic immunotherapy (ILIT) in patients with allergic rhinitis, publishing their results in 2008. Since then, 10 clinical trials that evaluated therapeutic efficacies and adverse effects of ILIT have been conducted. This article reviews the clinical trials of ILIT and suggests unmet needs in research fields of ILIT. (Allergy Asthma Respir Dis 2020;8:53-65)

KCI등재

3입원한 소아의 마이코플라스마 폐렴에서 치료 행태 분석: 다기관 후향적 연구

저자 : 이영주 ( Young Ju Lee ) , 안영민 ( Young Min Ahn ) , 장광천 ( Gwang Cheon Jang ) , 정혜리 ( Hai Lee Chung ) , 정은희 ( Eun Hee Chung ) , 황윤하 ( Yoon Ha Hwang ) , 심정연 ( Jung Yeon Shim )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 2호 발행 연도 : 2020 페이지 : pp. 66-72 (7 pages)

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Purpose: Macrolide-refractory Mycoplasma pneumoniae pneumonia (MP) has markedly increased since 2003 and corticosteroids or second-line antibiotics, such as fluoroquinolones or tetracyclines, was considered an alternative treatment modality in macrolide-refractory MP. We aimed to show the real-world treatment pattern of MP in hospitalized children and compared clinical and laboratory findings between children with and without steroid treatment.
Methods: We reviewed the medical records of 384 children diagnosed with MP from 6 hospitals in Korea from August 2015 to March 2016. We investigated the clinical, laboratory and radiologic findings, and medications used for the treatment of the subjects.
Results: The corticosteroids and second-line antibiotics were administered in 55.5% and 7.0%, respectively. The percentages of steroid administration varied from 17% to 69% in each hospital. The mean start date of corticosteroid administration was 3.4 hospital days. Patients with corticosteroid treatment had a longer length of hospital stay than those without corticosteroid. They exhibited higher rates of lobar pneumonia and pleural effusion, and required longer days until improvement in chest X-ray findings. They also had higher rates of allergic diseases and showed higher C-reactive protein levels at admission.
Conclusion: In the real-world practice studied in the 6 hospitals, corticosteroids were more frequently administered than second-line antibiotics to hospitalized children with MP. Children with corticosteroid adjuvant therapy had more severe pneumonia than those without. Randomized controlled trials are needed to make appropriate guidelines for macrolide-refractory MP. (Allergy Asthma Respir Dis 2020;8:66-72)

KCI등재

4일반병동에 입원한 호흡부전 소아에서 고습도 고유량 비캐뉼라의 유용성

저자 : 송근백 ( Kun Baek Song ) , 길홍량 ( Hong Ryang Kil ) , 조은영 ( Eun Young Cho ) , 이미희 ( Mi-hee Lee ) , 정은희 ( Eun Hee Chung )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 2호 발행 연도 : 2020 페이지 : pp. 73-79 (7 pages)

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Purpose: This study evaluated the clinical effects of heated humidified high flow nasal cannula (HHHFNC) treatment in pediatric patients with respiratory disease and respiratory insufficiency.
Methods: We reviewed the medical records for clinical features and tests performed in patients admitted to Chungnam University Hospital pediatric ward and treated with HHHFNC between July 2014 and December 2018. We evaluated the effects of HHHFNC treatment in patients with bronchiolitis treated with oxygen using a nasal prong.
Results: The 136 children were treated with HHHFNC during the study period, and their median age was 8 months. Among the 136 patients, 39 (28.7%) were diagnosed with bronchiolitis and pneumonia, 42 (30.9%) with pneumonia, 28 (20.6%) with bronchiolitis, and 3 (2.2%) with epilepsy. Thirty-five patients (25.7%) had underlying neurological disorders. Fifty-one (37.5%) received invasive ventilator treatment. After HHHFNC treatment, venous blood gas analysis showed a pH increase from 7.32 to 7.37 (P<0.05) and a decrease in partial pressure of carbon dioxide (pCO2) from 53.1 to 46.2 mmHg (P<0.05). The respiratory rate had decreased from 46.3 to 43.3/min (P<0.05). There were no statistically significant differences in hospital stay duration or intensive care unit admission rates between bronchiolitis patients receiving HHHFNC treatment and those not receiving.
Conclusion: In this study, in various diseases leading to pediatric respiratory insufficiency, HHHFNC treatment may improve physiologic parameters at the pediatric ward. HHHFNC may also be effective in patients with underlying neurological disorders and those with respiratory insufficiency from nonrespiratory infectious disease. (Allergy Asthma Respir Dis 2020;8:73-79)

KCI등재

5전연령 중증도별 식품알레르기의 주요 원인: 단일기관 최근 10년 후향적 조사 연구

저자 : 이은주 ( Eunjoo Lee ) , 정경욱 ( Kyunguk Jeong ) , 신유섭 ( Yoo-seob Shin ) , 남동호 ( Dong-ho Nahm ) , 박해심 ( Hae-sim Park ) , 최현나 ( Hyun-na Choi ) , 윤지원 ( Jiwon Yoon ) , 예영민 ( Young-min Ye ) , 이수영 ( Sooyoung Lee )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 2호 발행 연도 : 2020 페이지 : pp. 80-88 (9 pages)

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Purpose: Recent studies of food allergy (FA) at all ages are scanty in Korea. We performed this study to better understand severity-related and age-stratified causes of FA from infants to older adults in a single tertiary hospital in Korea.
Methods: A retrospective medical record review was performed on patients of all ages diagnosed with immediate-type FA between March 2008 and February 2018 in Ajou University Hospital.
Results: A total of 4,680 cases of FA among 2,733 patients were reported. The distribution of onset ages of the first FA symptom was as follows: 45.3% below 2 years, 16.2% at 2-6 years, 5.5% at 7-12 years, 4.0% at 13-18 years, 16.9% at 19-40 years, 10.4% at 41-65 years, and 1.8% above 65 years of age. The major 10 causative foods were hen's eggs (17.2%), cow's milk (16.7%), wheat (8.6%), crustaceans (8.5%), fish (4.6%), walnuts (4.4%), pork (3.2%), peanuts (3.2%), shellfish (3.0%), and peach (2.2%). The culprits ranked from the 11th to the 20th were as follows: soybean, apple, chicken, buckwheat, beef, kiwi, almonds, perilla seeds, tomato, and squid. The top 3 causative foods in children were hen's eggs, cow's milk, and wheat, while those in adults were crustaceans, wheat, and fish. Food-induced anaphylaxis was reported in 29.2% of all cases, with cow's milk, hen's eggs, wheat, crustaceans, fish, walnuts, pork, shellfish, buckwheat, and peanuts being the major 10 causes.
Conclusion: This study could provide a better understanding of the detailed ranks of the causes of FA according to severity and age in Korea. (Allergy Asthma Respir Dis 2020;8:80-88)

KCI등재

6Glutathione 주사에 의해 유발된 치명적인 천식발작 1예

저자 : 박정환 ( Jung Hwan Park ) , 김태희 ( Tae Hee Kim ) , 강민석 ( Min-suck Kang ) , 권도선 ( Do Sun Kwon ) , 변민광 ( Min Kwang Byun ) , 조재화 ( Jae Hwa Cho ) , 김형중 ( Hyung Jung Kim ) , 김재경 ( Jae Kyoung Kim ) , 박혜정 ( Hye Jung Park )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 2호 발행 연도 : 2020 페이지 : pp. 89-91 (3 pages)

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Baek-ok injection (glutathione) has been widely used antioxidant therapy to whiten and has antiaging effects in Korea. Glutathione is an enzyme which synthesizes leukotriene, then it can induce asthma attack theoretically; however, there have been few case reports concerning this therapy. In this report, we described a 41-year-old woman who developed glutathione-induced life-threatening asthma attack. She has asthma history controlled by an intermittent salbutamol inhaler. She developed general weakness and dyspnea right after glutathione injection, and injection was discontinued. Dyspnea was progressively aggravated, and she lost consciousness with shock. Cardiopulmonary resuscitation was started, and she arrived at the Emergency Department with wheezing, hypoxia, severe respiratory acidosis, and nonmeasurable blood pressure. Intubation and mechanical ventilation were started with intramuscular epinephrine/intravenous methylprednisolone injection and repeated salbutamol/ipratropium/budesonide inhalation. After 5 hours, extubation and spontaneous breathing were successful without wheezing. Next day, pulmonary function test showed moderate an obstructive airway disease pattern, and she was discharged with inhaled fluticasone/salmeterol, oral methylprednisolone, and montelukast. We can exclude anaphylaxis, because serum tryptase obtained at the Emergency Department was 0.0 mg/dL and the absence of skin lesions and angioedema at arrival. Baek-ok injection (glutathione) should be carefully performed in asthma patients. (Allergy Asthma Respir Dis 2020;8:89-91)

KCI등재

7임신 중 중증 천식지속상태 환자에서 체외막산소화장치 적용 1예

저자 : 옥혜성 ( Hye Sung Ock ) , 강래형 ( Lae Hyung Kang ) , 여혜주 ( Hye Ju Yeo ) , 윤성훈 ( Seong Hoon Yoon ) , 조우현 ( Woo Hyun Cho ) , 전두수 ( Doo Soo Jeon ) , 김윤성 ( Yun Seong Kim ) , 이승은 ( Seung Eun Lee )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 2호 발행 연도 : 2020 페이지 : pp. 92-95 (4 pages)

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Refractory status asthmaticus represents the most severe clinical presentations of asthma, and it is typically associated with the presence of hypoxemia, hypercapnia, lactic acidosis, dynamic hyperventilation and altered state of consciousness. Several case reports have demonstrated extracorporeal membrane oxygenation (ECMO) as an alternative treatment method for patients with status asthmaticus that failed to respond to maximal conventional therapy. We experienced a case of pregnant woman with severe asthma attack not relieved by conventional treatment, in whom early administration of ECMO resulted in a good outcome. A 23-year-old woman at, 11 weeks of pregnancy, was admitted with acute asthma attack. Despite maximal rescue therapies with mechanical ventilation, her condition gradually deteriorated. Venovenous ECMO was initiated 4 hours from intubation and gas exchange with lung mechanics was rapidly recovered within hours. She was extubated 45 hours after initiation of ECMO and had successful weaning from ECMO 2 days after extubation. The patient had no complication and gave birth to a healthy baby at 37 weeks of gestation. This is the first case report in Korea on the successful use of ECMO in a pregnant woman with severe respiratory insufficiency due to status asthmaticus, who failed to respond to mechanical ventilation and maximum pharmacological treatment. Early ECMO application is a useful treatment option for patients with refractory status asthmaticus refractory to conventional therapy. (Allergy Asthma Respir Dis 2020;8:92-95)

KCI등재

8호산구근막염: 증례보고와 문헌고찰

저자 : 조현웅 ( Hyun-woong Cho ) , 김현아 ( Hyun-ah Kim ) , 권미정 ( Mi Jung Kwon ) , 고성혜 ( Sung Hye Koh ) , 김주희 ( Joo-hee Kim ) , 김환일 ( Hwan Il Kim ) , 박지영 ( Ji-young Park ) , 박성훈 ( Sung-hoon Park ) , 황용일 ( Yong-il Hwang ) , 장승훈 ( Seung Hun Jang ) , 정기석 ( Ki-suck Jung )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 2호 발행 연도 : 2020 페이지 : pp. 96-101 (6 pages)

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Eosinophilic fasciitis (EF) is a scleroderma-like immune-allergic disorder of unknown etiology and pathogenesis. This rare disease is characterized by the progressive induration of the skin and soft tissue, and peripheral eosinophilia. Here, we report a case of EF. A 21-year-old female was referred due to edema in the upper and lower extremities for 1 month. Laboratory results were unremarkable except for severe eosinophilia. Parasite infestation, venous thrombosis, and cardiac and renal problems were excluded. Magnetic resonance imaging of both the lower extremities revealed symmetrical thickening and contrast enhancement of crural fascia with adjacent subcutaneous fat infiltration. A full-thickness biopsy at the lower extremity showed infiltration of the fascia by eosinophils, plasma cells, and lymphocytes with marked edema. Thus, this patient was confirmed to have EF and she was treated with systemic corticosteroids, resulting in a remarkable improvement in both edema and eosinophilia. (Allergy Asthma Respir Dis 2020;8:96-101)

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9토피라메이트와 관련된 독성표피괴사용해 1예

저자 : 유수정 ( Su Jeong You ) , 유수진 ( Soo Jin Yoo ) , 김효빈 ( Hyo-bin Kim )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 2호 발행 연도 : 2020 페이지 : pp. 102-104 (3 pages)

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Topiramate is an antiepileptic drug effective for multiple types of seizure and is also used to prevent migraine attack. Several side effects have been reported, such as metabolic acidosis, nephrolithiasis, anorexia, weight reduction, drowsiness, glaucoma, hyperthermia, and cognitive dysfunction, whereas skin manifestationis were rarely reported. We report a case of a 12-year-old girl on medication of topiramate for 8 months due to focal epilepsy. She had fever, sore throat, burning sense in the vaginal area, and then flaccid bullae and erythematous patches proceeded to the whole bodyskin and mucosa including the conjunctiva, oral cavity, and genital areas. She was diagnosed with toxic epidermal necrolysis (TEN) and improved after the discontinuation of topiramate and with administration of high-dose intravenous steroid and immunoglobulin. We, herein, report a girl who developed severe side effects on the skin, TEN, due to topiramate. (Allergy Asthma Respir Dis 2020;8:102-104)

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1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

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