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Allergy asthma & respiratory disease update

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수록정보
수록범위 : 1권1호(2013)~8권3호(2020) |수록논문 수 : 492
Allergy asthma & respiratory disease
8권3호(2020년 07월) 수록논문
최근 권호 논문
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KCI등재

1항암제 과민반응에 대한 탈감작요법

저자 : 정재우 ( Jae-woo Jung )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 3호 발행 연도 : 2020 페이지 : pp. 105-106 (2 pages)

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2요오드화 조영제 과민반응에 대한 임상 대처 최신 지견

저자 : 조민경 ( Min-kyoung Cho ) , 이서영 ( Suh-young Lee ) , 강혜련 ( Hye-ryun Kang )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 3호 발행 연도 : 2020 페이지 : pp. 107-113 (7 pages)

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Previously, immediate reactions to ionic high-osmolar iodinated contrast media (ICM) were regarded as nonimmunological. However, despite the use of lower-osmolar ICM, ICM hypersensitivity still occurs in some patients and recent studies suggest that there would be a true allergic response, especially in more severe form. Currently, it is important to identify the sensitized ICM and avoid the agent; however, the usefulness of skin tests and challenge tests has not yet been established, since there are few large-scale studies on them. Although, skin test-negative ICM can be safely used in clinical practice, conflicting results have been reported through various studies, depending on the challenge protocols used. Therefore, standard protocols need to provided. Even if a culprit agent is not proven by skin tests, its use should be avoided. Reuse of contrast media increases the risk of occurrence of hypersensitivity reactions. For patients with previous hypersensitivity reactions to contrast media, premedication can help prevent recurrence, but breakthrough in hypersensitivity is not fully achieved by premedication, especially when the previous reaction was a severe form such as anaphylaxis. Therefore, it is necessary to establish an optimal strategy to choose alternative ICM and premedication protocols to prevent recurrence of hypersensitivity reactions to nonionic contrast media. (Allergy Asthma Respir Dis 2020;8:107-113)

KCI등재

3알레르기질환의 발병에 미치는 인종과 혼합인종 가정의 역할

저자 : 김환수 ( Hwan Soo Kim ) , 김현희 ( Hyun Hee Kim )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 3호 발행 연도 : 2020 페이지 : pp. 114-118 (5 pages)

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Differences in the prevalence and severity of allergic diseases exist among racial and ethnic groups. However, influence of population admixing on allergic disease has not been studied. This review aimed to review studies in the literature which examined the difference in the prevalence and severity of allergic disease among populations with different ancestry and to discuss the effect of population admixing on the occurrence and severity of allergic disease. Several studies have shown that the prevalence and severity of asthma, allergic rhinitis, and atopic dermatitis were different according to ethnicity. However, there have been only a few studies evaluating the effect of population admixing on allergic disease. Ethnicity and environmental effect should be considered in the diagnosis and treatment of allergic disease. (Allergy Asthma Respir Dis 2020;8:114-118)

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4혈중 호염기구 수에 따른 성인 천식의 임상 양상 분석 및 호기 응축물 내 사이토카인과의 연관성 분석

저자 : 심지수 ( Ji-su Shim ) , 김민혜 ( Min-hye Kim ) , 조영주 ( Young-joo Cho )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 3호 발행 연도 : 2020 페이지 : pp. 119-126 (8 pages)

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Purpose: Although basophils are major effector cells involved in asthma, their pathophysiological role in asthma remains uncertain. In this study, we investigated the relationship between blood basophils, clinical features in asthmatics, and cytokines in exhaled breath condensate (EBC) which could be noninvasively obtained.
Methods: A total of 13 adult asthmatics were prospectively enrolled. We obtained information on demographics, asthma control levels, history of acute exacerbation as well as the asthma control test and Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA) scores. Peripheral blood and EBC samples were collected, and pulmonary function test was also performed. The association between blood basophil count and clinical feature and severity of asthma or inflammatory cytokines in EBC was analyzed.
Results: The percentage of blood basophils was positively correlated with that of blood eosinophils (Spearman r=0.665, P=0.013). The number of acute exacerbations was significantly larger (1.2±0.6 vs. 5.3±5.8, P=0.049) in the group with blood basophils ≥50 cells/μL, while the QLQAKA score was lower (68.8±7.9 vs. 49.0±12.0, P=0.028). There were no significant differences in age, atopy status, smoking history, and forced expiratory volume in 1 second according to blood basophil count. Blood basophil count was positively correlated with interleukin-33 (IL-33) (r=0.651, P=0.016) and IL-17 (r=0.732, P=0.004) in EBC.
Conclusion: Blood basophils may be associated with frequent asthma exacerbations and lower quality of life due to asthma. IL-33 and IL-17 may be the key mediators that stimulate basophils to participate in the pathogenesis of asthma. (Allergy Asthma Respir Dis 2020;8:119-126)

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5지역 사회 응급체계 구성원들의 아나필락시스에 대한 인지도 조사

저자 : 조현석 ( Hyunseok Cho ) , 김상하 ( Sang-ha Kim ) , 이지호 ( Ji-ho Lee ) , 김봉성 ( Bong-seong Kim ) , 이정민 ( Jeongmin Lee ) , 김자경 ( Ja Kyoung Kim ) , 박진성 ( Jin-sung Park ) , 권재우 ( Jae-woo Kwon )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 3호 발행 연도 : 2020 페이지 : pp. 127-134 (8 pages)

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Purpose: Anaphylaxis is life-threatening, so early recognition and proper response are critical. This study evaluated the awareness of anaphylaxis in Korean community including teachers, 119 rescue team, and doctors in public service.
Methods: A questionnaire of anonymously structured 9 items about anaphylaxis was administered to the teachers working in kindergartens or elementary schools, 119 rescue team, and public health physicians in Gangwon province in 2017. Additional questionnaire about knowledge on anaphylaxis management was administered to the physicians.
Results: A total of 415 people participated in the survey. About 4% of child care and health teachers experienced anaphylaxis within 1 year, but the overall awareness of anaphylaxis was very low, regardless of the educational level of anaphylaxis. 119 rescue teams experienced more anaphylactic patients, but they lacked knowledge of epinephrine administration and epinephrine autoinjector (EAI), independent of the educational level of anaphylaxis. Public health physicians had good knowledge of early treatment for anaphylaxis, but there was a lack of knowledge for epinephrine injection sites, observation plan, and EAI.
Conclusion: The awareness of anaphylaxis among community and emergency responders seems likely to be inadequate. Systematic and continuous education by anaphylaxis specialists is necessary for community health care providers. (Allergy Asthma Respir Dis 2020;8:127-134)

KCI등재

6Rituximab 과민반응 환자에서의 단일 농도 탈감작 프로토콜과 단계별 희석 탈감작 프로토콜의 비교

저자 : 김현화 ( Hyun Hwa Kim ) , 문미라 ( Mira Moon ) , 조민경 ( Min Kyoung Cho ) , 안경민 ( Kyung Min Ahn ) , 정수지 ( Soojie Chung ) , 강동윤 ( Dong Yoon Kang ) , 이서영 ( Suh Young Lee ) , 조상헌 ( Sang-heon Cho ) , 강혜련 ( Hye-ryun Kang )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 3호 발행 연도 : 2020 페이지 : pp. 135-141 (7 pages)

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Purpose: Rituximab is prone to infusion-related reactions, which commonly requires desensitization to maintain its administration. Conventional desensitization protocols are using multistep infusion by diluting solutions. However, the process of diluting drugs and stepwise delivery needs additional time and effort. The objective of this study was to investigate the safety and efficacy of a nondiluting, one-bag protocol of rituximab desensitization.
Methods: A retrospective study was performed by reviewing the medical records of patients who underwent rituximab desensitization between 2009 and 2018. The completion rate, occurrence and severity of breakthrough reactions (BTR), and time required to complete the therapy were compared between one-bag protocol and multibag protocol. Results were analyzed by generalized estimation equation method, and odds ratios (ORs) of completion rate and BTR incidence were estimated.
Results: Total 190 cases of desensitization therapy were performed in 49 patients; the incidence of BTR was 16.84% and the overall completion rate was 96.32%. No significant difference in completion rate was found (OR, 3.58; 95% confidence interval [CI], 0.79-16.38) and there was no significant difference in BTR incidence (OR, 0.81; 95% CI, 0.23-2.82) in one-bag protocol. BTR in the one-bag protocol tended to occur even through entire steps, whereas most of the BTR in the multibag protocol occurred at later steps of the process. The average time spent in the desensitization was 60 minutes shorter in the one-bag than the multibag protocol (258.15 minutes vs. 329.81 minutes, P<0.001).
Conclusion: One-bag desensitization protocol showed no significant difference in safety and efficiency compared to the conventional multibag protocol, with shortening the time required for completion. (Allergy Asthma Respir Dis 2020;8:135-141)

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7육고기 알레르기의 임상 양상

저자 : 김세진 ( Sejin Kim ) , 이재천 ( Jaechun Lee ) , 고아라 ( Ara Ko )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 3호 발행 연도 : 2020 페이지 : pp. 142-146 (5 pages)

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Purpose: Red meat allergy has recently been described as rare food hypersensitivity with unique pathogenesis and clinical relevance of delayed anaphylaxis. The culprits are various mammal meats containing oligosaccharide epitope (galactose-α-1,3-galactose, α-gal). Interestingly, hard tick bites precede the onset of this allergic condition. The clinical characteristics of red meat allergy had never been reported in Korea.
Methods: Among patients diagnosed with food hypersensitivity in a hospital located in Jeju, Korea, those with red meat allergy were recruited. Clinical characteristics were retrospectively reviewed and additionally interviewed.
Results: Five patients (mean age, 57±4 years; 4 males and 1 female) were diagnosed as having red meat allergy. They suffered from hives, as the most common symptom, followed by shortness of breath from 10 minutes to 6 hours after exposure to the culprits. Four patients visited the emergency department for anaphylaxis. Culprits included beef, pork, dog, ham, goat, and roe deer. Chicken, duck, bacon, or horse did not cause clinical symptoms. In 4 patients, hard tick bites preceded the onset. Detection of specific IgE to α-gal and culprits such as beef and pork facilitated the confirmative diagnosis. They were advised to avoid mammal meats and to receive a prescription for self-injectable epinephrine.
Conclusion: Red meat allergy is one of the food hypersensitivities, characterized by severe and delayed allergic reactions to various meats. Red meat allergy may be a tick-borne illness in Jeju, Korea. (Allergy Asthma Respir Dis 2020;8:142-146)

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8벌꿀에 의한 아나필락시스

저자 : 김지혜 ( Ji Hye Kim ) , 김단비 ( Danbi Kim ) , 김경훈 ( Kyunghoon Kim ) , 이혜진 ( Hye Jin Lee ) , 양은애 ( Eun Ae Yang ) , 김환수 ( Hwan Soo Kim ) , 전윤홍 ( Yoon Hong Chun ) , 김현희 ( Hyun Hee Kim ) , 김진택 ( Jin Tack Kim )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 3호 발행 연도 : 2020 페이지 : pp. 147-149 (3 pages)

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Honey is a food ingested worldwide. Allergic reaction to honey is rare and only a few cases have been reported in the literature. A 20-month-old boy developed angioedema 30 minutes after eating rice cake containing honey. After 2 weeks, we performed food challenge tests with honey which resulted in anaphylaxis. This is the first case report on anaphylaxis to honey in Korea. (Allergy Asthma Respir Dis 2020;8:147-149)

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9Diacerein에 의한 DRESS (drug reaction with eosinophilia and systemic symptoms) 환자에서 동반된 thromboembolic complication

저자 : 류효인 ( Hyo-in Rhyou ) , 엄수정 ( Soo-jung Um ) , 노미숙 ( Mee Sook Roh ) , 남영희 ( Young-hee Nam )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 3호 발행 연도 : 2020 페이지 : pp. 150-154 (5 pages)

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Diacerein is a safe drug for osteoarthritis due to its inhibitory effect on proinflammatory cytokines. Its common side effects, such as diarrhea, abdominal pain and skin rash, are relatively mild. There have been a few cases of drug reactions with eosinophilia and systemic symptoms (DRESS) syndrome accompanied by thromboembolic complications. We report the first case of diacerein-induced DRESS syndrome with thromboembolic complications. A 64-year-old man developed fever, skin rash, increase in liver enzymes, eosinophilia, deep vein thrombosis (DVT) and pulmonary thromboembolism (PTE) after taking diacerein. DVT and PTE were improved after anticoagulation therapy; however, fever, skin rash, eosinophilia and increase in liver enzymes were aggravated. A high-dose systemic corticosteroid (methylprednisolone 1 mg/kg/day) was administered, after which his clinical conditions improved. (Allergy Asthma Respir Dis 2020;8:150-154)

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10기질화 폐렴이 전신성 홍반성 루푸스의 초기 발현으로 나타난 한국 청소년 사례

저자 : 강소영 ( So-young Kang ) , 김수연 ( Soo Yeon Kim ) , 최선하 ( Sun Ha Choi ) , 설인숙 ( In Suk Sol ) , 김윤희 ( Yoon Hee Kim ) , 심효섭 ( Hyo Sup Shim ) , 이미정 ( Mi-jung Lee ) , 김경원 ( Kyung Won Kim ) , 손명현 ( Myung Hyun Sohn )

발행기관 : 대한천식알레르기학회(구 대한알레르기학회) 간행물 : Allergy asthma & respiratory disease 8권 3호 발행 연도 : 2020 페이지 : pp. 155-160 (6 pages)

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Organizing pneumonia is characterized histologically by the formation of granulation-tissue plugs within the lumens of small airways. It was reported in association with various disorders including infection, drug reactions and collagen vascular diseases. However, there have been only a few reports on organizing pneumonia accompanied by systemic lupus erythematosus (SLE), especially in the pediatric population. Herein, we report a case of an adolescent with SLE who initially developed respiratory illnesses due to organizing pneumonia. A 14-year-old girl was referred to our clinic for protracted cough with fever, dyspnea, and hemoptysis. Her chest x-ray revealed predominant multifocal consolidations in bilateral lung fields with pleural effusion. Computed tomography scan showed patchy consolidations with surrounding ground-glass opacities and a crazy paving appearance with multiple centrilobular nodules. Laboratory tests exhibited pancytopenia, elevated blood urea nitrogen and creatinine, proteinuria, low serum levels of complements, and positivity for antinuclear antibody and anti-double-stranded DNA antibody, which were suggestive of SLE. Lung biopsy was performed to exclude the possibility of vasculitis and other mixed connective tissue diseases, which confirmed focal organizing pneumonia. Systemic steroid therapy, including high-dose methylprednisolone, was started. After the treatment, her respiratory symptoms and radiologic findings showed significant improvements. The patient has been followed up so far, and she has remined disease-free. This pediatric case of organizing pneumonia as the initial presentation of SLE alerts clinicians to consider thorough assessment of pulmonary manifestations of SLE in children. (Allergy Asthma Respir Dis 2020;8:155-160)

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1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

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