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대한류마티스학회> Journal of Rheumatic Diseases(구 대한류마티스학회지)

Journal of Rheumatic Diseases(구 대한류마티스학회지) update

  • : 대한류마티스학회
  • : 의약학분야  >  정형외과학
  • : KCI등재
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  • : 연속간행물
  • : 계간
  • : 2093-940X
  • : 2233-4718
  • : 대한류마티스학회지(~2010)→Journal of Rheumatic Diseases(2011~)

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수록범위 : 1권1호(1994)~26권2호(2019) |수록논문 수 : 1,307
Journal of Rheumatic Diseases(구 대한류마티스학회지)
26권2호(2019년 04월) 수록논문
최근 권호 논문
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1Korean Guideline of Glucocorticoid-induced Osteoporosis; Time to Prevent Fracture!

저자 : Chang-hee Suh

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 26권 2호 발행 연도 : 2019 페이지 : pp. 87-89 (3 pages)

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3Psychiatric Symptoms in Systemic Lupus Erythematosus: Diagnosis and Treatment

저자 : Seoyoung Yoon , Dae Hun Kang , Tae Young Choi

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 26권 2호 발행 연도 : 2019 페이지 : pp. 93-103 (11 pages)

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According to the American College of Rheumatology classification, lupus erythematosus has five psychiatric manifestations, including cognitive dysfunction, mood disorder, anxiety disorder, psychosis, and acute confusional state, which are frequently accompanied by other symptoms. Cognitive dysfunction is the most common psychiatric manifestation in lupus patients with a prevalence rate ranging from 20% to 80%. The expression of psychiatric manifestations has been considered to be associated with disease activity, side effects of medications, and/or psychosocial stresses from the chronicity of lupus, but this has not been fully understood. Appropriate management of psychiatric symptoms is essential as it affects treatment adherence and quality of life. This review aimed to facilitate understanding of psychiatric manifestations of lupus through literature review on the prevalence, clinical features, diagnosis, and treatments of each psychiatric symptom. (J Rheum Dis 2019;26:93-103)

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4Causal Association between Bone Mineral Density and Osteoarthritis: A Mendelian Randomization Study

저자 : Gwan Gyu Song , Young Ho Lee

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 26권 2호 발행 연도 : 2019 페이지 : pp. 104-110 (7 pages)

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Objective. To examine whether bone mineral density (BMD) is causally associated with osteoarthritis (OA). Methods. We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighting (IVW), weighted median, and MR-Egger regression methods. We used publicly available summary statistics datasets of a genome-wide association study (GWAS) on femur neck (FN) BMD of individuals of European ancestry as the exposure and a GWAS for non-cancer illness code self-reported: OA from the individuals included in the UK Biobank as the outcome. Results. We selected 21 independent single- nucleotide polymorphisms with genome-wide significance (p<5.00E-08) from GWAS on FN BMD as the instrumental variables. The IVW method (beta=0.010, standard error [SE]=0.003, p=0.002) and the weighted median approach (beta=0.011, SE=0.004, p=0.006) yielded evidence of a causal association between FN BMD and OA. However, the MR-Egger analysis showed no causal association between FN BMD and OA (beta=0.005, SE=0.017, p=0.753). Since MR-Egger regression suffers from a lack of power and a susceptibility to weak instrument bias, the MR analysis results may support a causal association between FN BMD and OA. Conclusion. The results of MR analysis by IVW and weighted median, but not MR-Egger regression indicate that FN BMD is likely to be causally associated with an increased risk of OA incidence The current findings may provide an opportunity to elucidate the underlying mechanisms of the effects of BMD on the OA incidence. (J Rheum Dis 2019;26:104-110)

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5Usability Evaluation of an Image-based Pill Identification Application

저자 : Soo-kyung Cho , Bora Kim , Eunohk Park , Jieun Kim , Hokyoung Ryu , Yoon-kyoung Sung

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 26권 2호 발행 연도 : 2019 페이지 : pp. 111-123 (13 pages)

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Objective. To measure the accuracy and usability of an the image-processing based pill identifier application that we have developed. Methods. The subjects selected were medical residents and nurses. Five nurses and five physicians were randomly assigned to use either an the image-processing based pill identifier application (n=10), or the conventional pill identifier application (n=10). They were instructed to examine 10 pills using the application assigned to them, and searches that took <3 minutes to find candidate drugs were recognized as successes. Among these successful searches, the accuracy was defined to identify the correct names of the drugs and the times needed in the correctly identifications were also measured. After using one application the subjects were instructed to use the other one and repeat the same process. Finally, they answered a questionnaire on the usability of the applications. Results. The average proportion searches completed within 3 minutes was 91% for the the image-processing based pill identifier application, slightly, but not significantly, higher than that for the conventional pill identifier application (85%). The accuracies of the the image-processing based and conventional pill identifier applications were similar, 89% and 83%, respectively. In the usability examination, the the image-processing based pill identifier application yielded higher scores for the desirable, usable, findable and useful qualities than the conventional pill identifier application. Conclusion. The the image-processing based pill identifier application application has a similar accuracy to the existing conventional pill identifier application, and its usability was also found to be good. (J Rheum Dis 2019;26:111-117)

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6Relationship between Urate Crystal Deposits Detected by Dual-energy Computed Tomography and Bone Erosions in Symptomatic Gout Patients without Clinically Apparent Tophi

저자 : Min Kyung Chung , In Je Kim , Hyeran Hyun , Ji Young Hwang , Jisoo Lee

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 26권 2호 발행 연도 : 2019 페이지 : pp. 124-130 (7 pages)

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Objective. Dual-energy computed tomography (DECT) allows sensitive detection of monosodium urate (MSU) crystal deposits in gout. However, the role of MSU deposits on DECT during the disease process of gout is not clear. The aim of our study was to evaluate the relationship between joint damage and MSU deposits detected by DECT in symptomatic non-tophaceous gout. Methods. DECT scans of 51 gout patients without clinically apparent tophi were assessed. Individual ankle and foot joints and Achilles tendon insertion sites were evaluated for the presence of MSU deposits and bone erosions. The total volume of MSU crystal on DECT was quantified using an automated software program. Clinical and laboratory data at the time of the DECT evaluation were obtained from medical record. Results. MSU deposits were detected in 92.2% of the patients evaluated. Median number and total volume of MSU deposit per patient was 5.0 and 0.6 cm3, respectively. Bone erosion was found in 54.9% of patients. MSU deposits in the first (1st) metatarsophalangeal (MTP) joints were significantly associated with presence of bone erosions (odds ratio [OR] 3.77, 95% confidence interval [CI] 1.06∼13.38, p=0.040). Older age and frequent gout attack were associated with development of bone erosion in patients with MSU deposits (OR 1.12 and 2.57, 95% CI 1.04∼1.22 and 1.02∼ 6.50, p-value 0.004 and 0.047, respectively). Conclusion. MSU deposits and erosions were frequently detected by DECT in symptomatic non-tophaceous gout patients, and MSU deposits in 1st MTP joints were associated with presence of bone erosions especially in patients with older age and frequent gout attack. (J Rheum Dis 2019;26:124-130)

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7Causal Association between Rheumatoid Arthritis with the Increased Risk of Type 2 Diabetes: A Mendelian Randomization Analysis

저자 : Young Ho Lee , Gwan Gyu Song

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 26권 2호 발행 연도 : 2019 페이지 : pp. 131-141 (11 pages)

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Objective. This study aimed to examine whether rheumatoid arthritis (RA) is causally associated with type 2 diabetes (T2D). Methods. We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We used the publicly available summary statistics datasets from a genome- wide association studies (GWAS) meta-analysis of 5,539 autoantibody-positive individuals with RA and 20,169 controls of European descent, and a GWAS dataset of 10,247 individuals with T2D and 53,924 controls, overwhelmingly of European descent as outcomes. Results. We selected 10 single-nucleotide polymorphisms from GWAS data on RA as instrumental variables to improve the inference. The IVW method supported a causal association between RA and T2D (β=0.044, standard error [SE]=0.022, p=0.047). The MR-Egger analysis showed a causal association between RA and T2D (β=0.093, SE=0.033, p=0.023). In addition, the weighted median approach supported a causal association between RA and T2D (β=0.056, SE=0.025, p=0.028). The association between RA and T2D was consistently observed using IVW, MR Egger, and weighted median methods. Cochran's Q test indicated no evidence of heterogeneity between instrumental variable estimates based on individual variants and MR-Egger regression revealed that directional pleiotropy was unlikely to have biased the results (intercept=- 0.030; p=0.101). Conclusion. MR analysis supports that RA may be causally associated with an increased risk of T2D. (J Rheum Dis 2019;26:131-136)

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8Causal Association between Rheumatoid Arthritis with the Increased Risk of Type 2 Diabetes: A Mendelian Randomization Analysis

저자 : Young Ho Lee , Gwan Gyu Song

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 26권 2호 발행 연도 : 2019 페이지 : pp. 131-135 (5 pages)

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Objective. This study aimed to examine whether rheumatoid arthritis (RA) is causally associated with type 2 diabetes (T2D). Methods. We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We used the publicly available summary statistics datasets from a genome- wide association studies (GWAS) meta-analysis of 5,539 autoantibody-positive individuals with RA and 20,169 controls of European descent, and a GWAS dataset of 10,247 individuals with T2D and 53,924 controls, overwhelmingly of European descent as outcomes. Results. We selected 10 single-nucleotide polymorphisms from GWAS data on RA as instrumental variables to improve the inference. The IVW method supported a causal association between RA and T2D (β=0.044, standard error [SE]=0.022, p=0.047). The MR-Egger analysis showed a causal association between RA and T2D (β=0.093, SE=0.033, p=0.023). In addition, the weighted median approach supported a causal association between RA and T2D (β=0.056, SE=0.025, p=0.028). The association between RA and T2D was consistently observed using IVW, MR Egger, and weighted median methods. Cochran's Q test indicated no evidence of heterogeneity between instrumental variable estimates based on individual variants and MR-Egger regression revealed that directional pleiotropy was unlikely to have biased the results (intercept=- 0.030; p=0.101). Conclusion. MR analysis supports that RA may be causally associated with an increased risk of T2D. (J Rheum Dis 2019;26:131-136)

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9A Case of Hepatic Inflammatory Pseudotumor Occurred in a Patient with Lupus Nephritis

저자 : Min Jung Kim , Hyoungyoung Kim , Yeo-jin Song , Soo-kyung Cho , Yoon-kyoung Sung

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 26권 2호 발행 연도 : 2019 페이지 : pp. 137-143 (7 pages)

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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease affecting various organs. Among its manifestations, inflammatory pseudotumor (IPT) is an extremely rare disease about which no case has been reported of it occurring in the liver. We present a case of a SLE patient with hepatic IPT (hIPT) successfully treated with immunosuppressants. A 16-year-old male with elevated liver enzymes visited our clinic and was diagnosed as SLE. Although no lesion was observed in the initial abdomen ultrasonography, the abdominal CT on hospital day 7 revealed a new hepatic mass resembling an abscess. Despite 5 weeks of antibiotics treatment, the hepatic mass remained, and was re-diagnosed as hIPT secondary to SLE with an abdominal MRI. After high dose prednisolone and mycophenolate mofetil treatment, lupus activity subsided and hIPT disappeared in the follow- up CT. This case suggests that hIPT should be considered as a differential diagnosis among hepatic mass in SLE patients. (J Rheum Dis 2019;26:137-141)

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10Very Rapidly Progressive Shoulder Arthropathy with Complete Destruction of the Humeral Head

저자 : Wooseong Jeong , Jinseok Kim , Sungwook Choi , Hyunseong Kang

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 26권 2호 발행 연도 : 2019 페이지 : pp. 142-146 (5 pages)

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Milwaukee shoulder syndrome (MSS) is a rare disease in which joints are destroyed and occurs mainly in elderly women. We describe rapidly progressive MSS with complete destruction of the shoulder joint within 2 months. An 80-year-old woman visited the outpatient clinic with shoulder pain for 2 weeks. rotator cuff tear arthropathy was diagnosed, and nonsteroidal anti-inflammatory drugs were prescribed. Two months later, her shoulder pain worsened without trauma. Shoulder swelling and tenderness, and arm lifting inability were observed. Complete humeral head disruption was observed by radiography. We diagnosed MSS based on the presence of serohematic and noninflammatory joint effusion, periarticular calcific deposits, and rapid joint destruction, and initiated conservative treatment. When initially treating elderly patients with shoulder arthropathy, it is advisable to perform short-term follow-up and to consider the possibility of crystal-induced arthropathy. (J Rheum Dis 2019;26: 142-146)

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