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대한류마티스학회> Journal of Rheumatic Diseases(구 대한류마티스학회지)

Journal of Rheumatic Diseases(구 대한류마티스학회지) update

  • : 대한류마티스학회
  • : 의약학분야  >  정형외과학
  • : KCI등재
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  • : 연속간행물
  • : 계간
  • : 2093-940X
  • : 2233-4718
  • : 대한류마티스학회지(~2010)→Journal of Rheumatic Diseases(2011~)

수록정보
수록범위 : 1권1호(1994)~27권2호(2020) |수록논문 수 : 1,344
Journal of Rheumatic Diseases(구 대한류마티스학회지)
27권2호(2020년 04월) 수록논문
최근 권호 논문
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1Serum and Urine Uric Acid as a Biomarker in Osteoarthritis

저자 : Jae-bum Jun

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 27권 2호 발행 연도 : 2020 페이지 : pp. 75-77 (3 pages)

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2What is the Best Choice for Urate-lowering Therapy for Korean?

저자 : Yun-hong Cheon , Jung Soo Song

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 27권 2호 발행 연도 : 2020 페이지 : pp. 78-87 (10 pages)

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Gout is one of the most common forms of acute inflammatory arthritis caused by long-standing hyperuricemia. Various clinical and epidemiological studies have demonstrated that uric acid, which is strongly associated with the pathogenesis of gout, is closely related with increased cardiovascular (CV) risk. Thus, properly controlling uric acid levels within its physiological level using urate-lowering therapy has been hypothesized to improve CV outcomes. Recently, however, on the basis of the results of the largest prospective, the double-blind, randomized controlled trial, entitled “the Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout (CARES),” has aroused the possibility of increased CV-related and all-cause mortality in patients receiving febuxostat. Largely on the basis of this unpredicted result, the US and Korea Food and Drug Administration issued a public safety alert concerning the high risk of CV death with the use of febuxostat in February 2019. This unexpected announcement left many rheumatologists confused when they decide the first-line urate-lowering drug in Korea. In this review, we searched for previous studies on uric acid and increased risk of CV disease. In addition, we will introduce various interpretations of the results of the CARES trial and discuss the best choice of urate-lowering therapy for Korean.

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3The Uric Acid and Gout have No Direct Causality With Osteoarthritis: A Mendelian Randomization Study

저자 : Young Ho Lee , Gwan Gyu Song

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 27권 2호 발행 연도 : 2020 페이지 : pp. 88-95 (8 pages)

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Objective. To examine whether uric acid level or gout is causally associated with the risk of osteoarthritis. Methods. We performed a two-sample Mendelian randomization (MR) analysis using inverse-variance weighted (IVW), MR-Egger regression, and weighted median methods. We used the publicly available summary statistics datasets of uric acid level or gout genome- wide association studies (GWASs) as the exposure, and a GWAS in 3,498 patients with osteoarthritis in the arcOGEN study and 11,009 controls of European ancestry as the outcome. Results. Six single nucleotide polymorphisms (SNPs) from the GWAS data on uric acid level and 12 SNPs from the GWAS data on gout were selected as instrumental variables (IVs). The IVW analysis did not support a causal association between uric acid level or gout and risk of osteoarthritis (beta=-0.026, standard error [SE]=0.096, p=0.789; beta=-0.018, SE=0.025, p=0.482). MR-Egger regression revealed no causal association between uric acid level or gout and risk of osteoarthritis (beta=0.028, SE=0.142, p=0.852; beta=-0.056, SE=0.090, p=0.548). Similarly, no evidence of a casual association was provided by the weighted median approach (beta=0.004, SE=0.064, p=0.946; beta=-0.005, SE=0.025, p=0.843). Conclusion. The results of MR analysis demonstrates that uric acid level and gout may be not causally associated with the increased risk of osteoarthritis. Considering MR study is not susceptible to bias from unmeasured confounders or reverse causation, the epidemiological evidence for an association between uric acid level or gout and a higher risk of osteoarthritis may be due to residual confounding or reverse causation rather than direct causality.

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4Clinical Significance of Elevated Serum Immunoglobulin G4 Levels in Patients With Rheumatoid Arthritis

저자 : Sang-hyon Kim , Hye-jin Jeong , Ji-min Kim , Jae-bum Jun , Chang-nam Son

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 27권 2호 발행 연도 : 2020 페이지 : pp. 96-99 (4 pages)

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Objective. This study aimed to evaluate the relationship between serum immunoglobulin G4 (IgG4) levels and the presence and disease activity of rheumatoid arthritis (RA). Methods. The study enrolled 128 participants (RA, 96; healthy controls, 17; osteoarthritis, 11; and IgG4-related disease, 4) between March 2014 and July 2017. Blood samples were collected prior to the commencement of treatment, and serum IgG4 levels were determined using a nephelometric assay (levels ≥135 mg/dL were considered elevated). The levels of serum IgG4 and the ratio of IgG4/total IgG in patients with RA were compared with those in healthy controls, patients with osteoarthritis, and patients with IgG4-related disease. Furthermore, the relationship between serum IgG4 levels and RA disease activity was evaluated. Results. Among the 96 patients with RA, the mean (±standard deviation) serum IgG4 level was 48.0±45.4 mg/dL; 6 (6.3%) patients had elevated serum IgG4 levels. However, none of the healthy controls or patients with osteoarthritis had elevated serum IgG4 levels. The mean serum IgG4/IgG ratio in patients with RA was 3.5%±2.8% (range, 0.2%∼16.9%). Using Spearman's correlation coefficient analysis, a significant correlation was found between serum IgG4 levels and the Disease Activity Score-28 with erythrocyte sedimentation rate (r, 0.245; p=0.016). Conclusion. There was an increased frequency of elevated serum IgG4 levels in patients with RA, and the levels were correlated with RA disease activity.

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5Comparison of Clinical, Angiographic Features and Outcome in Takayasu's Arteritis and Behçet's Disease With Arterial Involvement

저자 : Su Jin Choi , Hyun Jung Koo , Dong Hyun Yang , Joon-won Kang , Ji Seon Oh , Seokchan Hong , Yong-gil Kim , Bin Yoo , Chang-keun Lee

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 27권 2호 발행 연도 : 2020 페이지 : pp. 100-109 (10 pages)

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Objective. Takayasu's arteritis (TAK) is a vasculitis that primarily involves the aorta and its branches. In Behçet's disease (BD), systemic vasculitis is one of major manifestations. We aimed to compare clinical and angiographic features and outcome between TAK and BD with arterial involvement. Methods. We retrospectively reviewed medical records of 206 TAK patients and 50 BD patients between 1995 and 2015. Angiographic lesions were evaluated via computed tomography, magnetic resonance imaging, and/or conventional angiography. Results. Fever (30% vs. 9.2%, p<0.001) and arthralgia (36% vs. 7.3%, p<0.001) were more common in BD. C-reactive protein was higher in BD compared with TAK (5.85 mg/dL vs. 2.08 mg/dL, p<0.001). Stenosis (89.8% vs. 60%, p<0.001) and occlusion (65.5% vs. 32%, p<0.001) were more observed in TAK. In contrast, aneurysm was common in BD (62% vs. 20.9%, p<0.001). The carotid artery (73.3% vs. 30%, p<0.001), subclavian artery (71.4% vs. 16%, p<0.001), descending aorta (35% vs. 12%, p=0.002), renal artery (23.8% vs. 10%, p=0.032), superior mesenteric artery (18.4% vs. 4%, p=0.012), and brachiocephalic trunk (13.6% vs. 2%, p=0.020) were more commonly involved in TAK, whereas the femoral artery (10% vs. 2.4%, p=0.027) was more frequently involved in BD. During follow-up, arterial dissection (10% vs. 1.9%, p=0.016), rupture (12% vs. 0.5%, p<0.001), and arterial replacement/resection (66% vs. 9.7%, p<0.001) were more observed in BD. Conclusion. TAK differs from BD regarding clinical features and vascular involvement patterns. BD exhibits a higher rate of vascular complications.

KCI등재

6Circulating Interleukin-18 Level in Systemic Lupus Erythematosus

저자 : Young Ho Lee , Gwan Gyu Song

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 27권 2호 발행 연도 : 2020 페이지 : pp. 110-115 (6 pages)

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Objective. This study aimed to evaluate the relationship between circulating interleukin (IL)-18 levels and systemic lupus erythematosus (SLE) and establish a correlation between plasma/serum IL-18 levels and SLE activity. Methods. We performed a meta-analysis comparing plasma/serum IL-18 levels in patients with SLE to controls by using fixed or random effects model based on the heterogeneity. Results. Sixteen studies with 659 SLE patients and 502 controls were included in this meta-analysis. Meta-analysis showed that IL-18 levels were significantly higher in the SLE group (standardized mean difference=1.556, 95% confidence interval=1.087∼2.024, p<0.001). Stratifying by ethnicity showed that IL-18 levels were significantly elevated in the SLE groups of European, Asian, and Arab populations. Stratification by adjustment for age and/or sex revealed a significantly higher IL-18 level in the SLE group, independently of the adjustment. Subgroup analysis by sample size showed significantly higher IL-18 levels in the SLE group for both large sample (n≥50) and small sample (n<50) subgroups. Subgroup analysis by data type showed significantly higher IL-18 levels in the SLE group for both original and calculated data populations. Conclusion. This meta-analysis demonstrated that circulating IL-18 levels are higher in patients with SLE.

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7Combination of Methotrexate and Leflunomide for Adult-onset Still's Disease: A Case Report and Literature Review

저자 : Eunyoung Emily Lee , Min Jung Kim , Yeong Wook Song , Jin Kyun Park

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 27권 2호 발행 연도 : 2020 페이지 : pp. 116-119 (4 pages)

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The treatment of adult-onset Still's disease (AOSD) aims to control systemic inflammation and prevent organ damage. Systemic inflammation can be controlled with corticosteroid (CS) monotherapy in most cases. However, symptoms often flare as CS is tapered, often requiring long-term CS treatment, with its associated risks of infection, cardiovascular disease, and osteoporosis. Disease-modifying antirheumatic drugs (DMARDs) are often used as CS-sparing agents; however, the choice of DMARD has been largely empirical. Methotrexate (MTX) is recommended as the first-line steroid-sparing drug due to its well-known efficacy and safety in rheumatoid arthritis (RA). When MTX treatment is unsuccessful in AOSD, the choice of a second-line drug has not been established. In RA, leflunomide (LEF) has been used as an alternative to or in combination with MTX. To date, there has been no adequate assessment of the combination of LEF and MTX in AOSD. Here, we report a case of refractory chronic AOSD successfully treated with the MTX-LEF combination.

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8Rapidly Progressive Pansclerotic Morphea Associated With Raynaud Phenomenon

저자 : Rkiouak Adil , El Kassimi Ilyas , Sahel Nawal , Zaizaa Meryem , Mohamed Tbouda , Sekkach Youssef

발행기관 : 대한류마티스학회 간행물 : Journal of Rheumatic Diseases(구 대한류마티스학회지) 27권 2호 발행 연도 : 2020 페이지 : pp. 120-122 (3 pages)

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