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Gut and Liver update

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수록범위 : 1권1호(2007)~13권2호(2019) |수록논문 수 : 1,141
Gut and Liver
13권2호(2019년 03월) 수록논문
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KCI등재 SCI SCOPUS

1Insulin Resistance: A Hidden Risk Factor for Gastric Cancer?

저자 : Yoon Jin Choi

발행기관 : 대한소화기내시경학회 간행물 : Gut and Liver 13권 2호 발행 연도 : 2019 페이지 : pp. 133-134 (2 pages)

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KCI등재 SCI SCOPUS

2Drainage Procedures for the Treatment of Walled-Off Pancreatic Necrosis: Is More Refinement Necessary?

저자 : Sung-hoon Moon

발행기관 : 대한소화기내시경학회 간행물 : Gut and Liver 13권 2호 발행 연도 : 2019 페이지 : pp. 135-137 (3 pages)

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3Can Statin Prevent the Risk of Colorectal Cancer in Patients with Inflammatory Bowel Disease?

저자 : Hyun Joo Jang

발행기관 : 대한소화기내시경학회 간행물 : Gut and Liver 13권 2호 발행 연도 : 2019 페이지 : pp. 138-139 (2 pages)

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4Blue Laser Imaging, Blue Light Imaging, and Linked Color Imaging for the Detection and Characterization of Colorectal Tumors

저자 : Naohisa Yoshida , Osamu Dohi , Ken Inoue , Ritsu Yasuda , Takaaki Murakami , Ryohei Hirose , Ken Inoue , Yuji Naito , Yutaka Inada , Kiyoshi Ogiso , Yukiko Morinaga , Mitsuo Kishimoto , Rafiz Abdul Rani ,

발행기관 : 대한소화기내시경학회 간행물 : Gut and Liver 13권 2호 발행 연도 : 2019 페이지 : pp. 140-148 (9 pages)

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A laser endoscopy system was developed in 2012. The system allows blue laser imaging (BLI), BLI-bright, and linked color imaging (LCI) to be performed as modes of narrowband light observation; these modes have been reported to be useful for tumor detection and characterization. Furthermore, an innovative endoscopy system using four-light emitting diode (LED) multilight technology was released in 2016 to 2017 in some areas in which laser endoscopes have not been approved for use, including the United States and Europe. This system enables blue light imaging (this is also known as BLI) and LCI with an LED light source instead of a laser light source. Several reports have shown that these modes have improved tumor detection. In this paper, we review the efficacy of BLI and LCI with laser and LED endoscopes in tumor detection and characterization. (Gut Liver 2019;13:140-148)

KCI등재 SCI SCOPUS

5Current Definition of and Controversial Issues Regarding Postoperative Pancreatic Fistulas

저자 : Giovanni Marchegiani , Stefano Andrianello , Roberto Salvia , Claudio Bassi

발행기관 : 대한소화기내시경학회 간행물 : Gut and Liver 13권 2호 발행 연도 : 2019 페이지 : pp. 149-153 (5 pages)

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The International Study Group for Pancreatic Fistula (ISGPF) made the first attempt to standardize the outcome measure of fistulas in the field of pancreatic surgery by publishing the definition and classification of postoperative pancreatic fistulas (POPFs) in 2005. POPFs were determined by any measurable volume of fluid output via an operatively placed drain with amylase activity greater than three times the upper normal serum value. Taking into account more than 10 years of reported experience worldwide, the updated definition published in 2016 by the reconvened International Study Group for Pancreatic Surgery (ISGPS) attempted to overcome the limits of the previous classification. The crucial concept of POPF clinical significance was introduced by eliminating grade A from the fistula scenario. The wider use of interventional procedures has also made it necessary to recode grade C POPFs, which now have clearer boundaries, toward the worst end of the severity scale. Grade B still represents the most prevalent and heterogeneous category of POPFs, both in terms of clinical burden and management. In the near future, further efforts will be required to better stratify grade B POPFs to standardize treatment strategies and compare outcomes among institutions. (Gut Liver 2019;13:149- 153)

KCI등재 SCI SCOPUS

6Insulin Resistance Is Associated with Early Gastric Cancer: A Prospective Multicenter Case Control Study

저자 : Hye Jung Kwon , Moo In Park , Seun Ja Park , Won Moon , Sung Eun Kim , Jae Hyun Kim , Youn Jung Choi , Sang Kil Lee

발행기관 : 대한소화기내시경학회 간행물 : Gut and Liver 13권 2호 발행 연도 : 2019 페이지 : pp. 154-160 (7 pages)

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Background/Aims: Recently, increased body weight has been found to be associated with an increasing risk of several cancers, including gastric cancer. The true pathogenic role of hyperglycemia in the development of gastric cancer remains unclear as hyperglycemia and its associated conditions may work as carcinogenic factors. The goal of this study was to clarify the factors associated with early gastric cancer and evaluate a homeostasis model assessment of the insulin resistance (HOMA-IR) index, fasting glucose, and lipid profile as predictors of early gastric cancer. Methods: A total of 63 patients with early gastric cancer between November 2012 and March 2013 were included. Preoperative serum lipid profile levels and serum fasting glucose were examined prospectively in patients with early gastric cancer. The same number of controls were evaluated and matched to the early gastric cancer group for age and gender. We performed multivariate logistic regression analysis to identify independent risk factors for early gastric cancer. Results: Univariate analysis showed that risk for early gastric cancer was associated with diastolic blood pressure (BP), total cholesterol, fasting glucose, and HOMA-IR. In the multivariate-adjusted model, higher total cholesterol, fasting glucose, body mass index, and diastolic BP were strongly associated with an increased risk of early gastric cancer. Conclusions: Hyperglycemia, a lower high-density lipoprotein cholesterol level, and a low HOMA-IR level appear to be associated with early gastric cancer risk. (Gut Liver 2019;13:154-160)

KCI등재 SCI SCOPUS

7Predicting Malignancy Risk in Gastrointestinal Subepithelial Tumors with Contrast-Enhanced Harmonic Endoscopic Ultrasonography Using Perfusion Analysis Software

저자 : Hyun Seok Lee , Chang Min Cho , Yong Hwan Kwon , Su Youn Nam

발행기관 : 대한소화기내시경학회 간행물 : Gut and Liver 13권 2호 발행 연도 : 2019 페이지 : pp. 161-168 (8 pages)

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Background/Aims: Contrast-enhanced harmonic endoscopic ultrasonography (CEH-EUS) is a promising imaging modality that can differentiate subepithelial tumors (SETs) by detecting the degree of enhancement. However, whether CEHEUS alone can predict the malignancy risk of gastrointestinal stromal tumors (GISTs) remains unclear. This study aimed to evaluate the feasibility of CEH-EUS by using perfusion analysis software for distinguishing among SETs and predicting the malignancy risk of GISTs. Methods: We retrospectively included patients with SETs who underwent preoperative CEH-EUS. In this study, 44 patients with histologically proven GISTs and benign SETs were enrolled. Perfusion analysis was performed using perfusion quantification software. Peak enhancement (PE), wash-in rate (WiR), wash-in perfusion index (WiPI), and wash-in and wash-out areas under the time-intensity curve (WiWoAUC) were calculated and compared between the GISTs and benign SETs. Results: When we allocated the enrolled patients into the leiomyoma group and low- and high-grade malignancy GIST groups, significant statistical differences in PE (p<0.001), WiR (p=0.009), WiPI (p<0.001), and WiWoAUC (p<0.001) were identified in the high-grade malignancy group compared with the leiomyoma group. Conclusions: CEH-EUS with perfusion analysis using perfusion analysis software could be a quantitative and independent method for predicting malignancy risk in gastrointestinal SETs. (Gut Liver 2019;13:161-168)

KCI등재 SCI SCOPUS

8Usefulness of Personal Bowel Habits as a Predictive Factor for Inadequate Bowel Preparation for Colonoscopy: A Prospective Questionnaire-Based Observational Study

저자 : Namyoung Paik , Eun Ran Kim , Tae Jun Kim , Sung Noh Hong , Dong Kyung Chang , Young-ho Kim

발행기관 : 대한소화기내시경학회 간행물 : Gut and Liver 13권 2호 발행 연도 : 2019 페이지 : pp. 169-175 (7 pages)

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Background/Aims: The quality of bowel preparation is important for optimal colonoscopy. It is influenced by medical and personal factors. We aimed to evaluate the effect of bowel habit on the quality of bowel preparation and to identify predictors of inadequate bowel preparation among bowel habit factors. Methods: From June 2017 to September 2017, 90 volunteers were enrolled in this study. Each participant answered a questionnaire consisting of multiple questions about personal bowel habits, including stool form, frequency of bowel movements per week, duration, and degree of straining for bowel movement. Then, all volunteers underwent colonoscopic exam. Eleven endoscopists performed colonoscopies and used the Boston Bowel Preparation Scale (BBPS) as the index for bowel preparation. Two expert endoscopists simultaneously reviewed all colonoscopic images to confirm the final BBPS. Univariate and multivariate logistic regression analyses were performed to verify the correlation between bowel preparation adequacy and bowel habit. Results: Among the 90 participants, 20 (22.2%) had inadequate bowel preparation (total BBPS ≤6 or any segmental BBPS ≤1). In univariate analysis, infrequent bowel movement (0-2/week) (odds ratio [OR], 12.60; 95% confidence interval [CI], 1.22 to 129, p=0.03) and moderate straining (more than 1/4 of defecations) (OR, 4.40; 95% CI, 1.44 to 13.39; p=0.01) were significantly associated with inadequate bowel preparation. However, only moderate straining was significantly associated with inadequate bowel preparation in multivariate analysis (OR, 3.99; 95% CI, 1.26 to 12.65; p=0.02). Conclusions: Straining is a significant predictor for inadequate bowel preparation. For patients with straining during bowel movements, an intensified preparation regimen should be considered. (Gut Liver 2019;13:169-175)

KCI등재 SCI SCOPUS

9Safety and Efficacy of Low-Volume Preparation in the Elderly: Oral Sulfate Solution on the Day before and Split-Dose Regimens (SEE SAFE) Study

저자 : Min Seob Kwak , Jae Myung Cha , Hyo-joon Yang , Dong Il Park , Kyeong Ok Kim , Jun Lee , Jeong Eun Shin , Young-eun , Joo , Jongha Park , Jeong-sik Byeon , Hyun Gun Kim

발행기관 : 대한소화기내시경학회 간행물 : Gut and Liver 13권 2호 발행 연도 : 2019 페이지 : pp. 176-182 (7 pages)

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Background/Aims: The use of a low-volume bowel cleansing agent is associated with a greater willingness to undergo repeat colonoscopy. Oral sulfate solution (OSS) is a recently approved low-volume agent; however, its efficacy and safety in the elderly population remain unclear. We aimed to evaluate the efficacy, safety, and acceptability of the OSS preparation, in comparison to those of a standard polyethylene glycol (PEG; 4 L) preparation, in elderly patients. Methods: A multicenter, randomized, investigator-blinded study was conducted. Participants were randomized to receive OSS or 4-L PEG with a split-dose regimen. Bowel cleansing efficacy was assessed using the Boston Bowel Preparation Scale (BBPS). Acceptance, satisfaction, and preparation-related symptoms were recorded. Additionally, blood parameters were analyzed for electrolyte abnormalities and nephrotoxicity. Results: A total of 193 patients were analyzed. No group differences in overall bowel cleansing efficacy were observed, with “adequate” preparations achieved in 95.9% (93/97) and 94.8% (91/96) of patients in the OSS and 4L PEG groups, respectively (p=0.747). However, mean BBPS scores for the entire (p=0.010) and right colon (p=0.001) were significantly higher in the OSS group than in the 4-L PEG group. The severity of clinical adverse events and frequency of acute kidney injury were similarly low, and no clinically meaningful electrolyte changes were identified. Self-reported scores regarding amount (p<0.001) and feeling (p=0.007), as well as overall satisfaction (p=0.001) and willingness to repeat the preparation (92.8% vs 67.7%, p<0.001), were significantly better in the OSS group than in the 4-L PEG group. Conclusions: In elderly individuals, OSS with a split-dose regimen has greater acceptability and comparable efficacy in bowel cleansing compared to 4-L PEG. (Clinical trials registration number: NCT03112967) (Gut Liver 2019;13:176-182)

KCI등재 SCI SCOPUS

10What Are the Clinical Features and Etiology of Eosinophilic Liver Infiltration?

저자 : Da Woon Sim , Dong Jun Son , Eunae Cho , Sung Kyu Choi , Sang Soo Shin , Chung Hwan Jun

발행기관 : 대한소화기내시경학회 간행물 : Gut and Liver 13권 2호 발행 연도 : 2019 페이지 : pp. 183-190 (8 pages)

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Background/Aims: Although eosinophilic liver infiltration (ELI) is not rare, few data exist regarding its clinical characteristics and etiology. Therefore, we evaluated these aspects to better understand the clinical implications of this lesion type, which is reasonably common in Korea. Methods: Patients suspected of having ELI, based on abdominal computed tomography results obtained between January 2010 and September 2017, were enrolled in this retrospective study. The presumptive etiologies of ELI were categorized as parasite infections, hypereosinophilic syndrome (HES), eosinophilic granulomatosis with polyangiitis (EGPA), malignancies, and unidentified. Clinical courses and treatment responses were also evaluated. Results: The mean age of the enrolled patients (male, 237/328) was 62 years. Most patients (63%) were diagnosed incidentally and had peripheral eosinophilia (90%). Only 38% of the enrolled patients (n=126) underwent further evaluations to elucidate the etiology of the suspected ELI; 82 (25%) had parasite infections, 31 (9%) had HES, five (2%) had EGPA, and five (2%) had drug reactions in conjunction with eosinophilia and systemic symptoms. Almost half of the other enrolled patients had cancer. Radiologic resolution was achieved in 191 patients (61%; median time to radiologic resolution, 185 days). Resolution of peripheral eosinophilia was achieved in 220 patients (79%). In most cases, the course of ELI was benign. Conclusions: This large ELI study is unique in that the incidence rate, underlying diseases, and clinical courses were comprehensively evaluated. Clinicians should investigate the etiology of ELI, as several of the underlying diseases require intervention rather than observation. (Gut Liver 2019;13:183-190)

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순천향대학교 마산대학교 Duke University 신구대학교 동의대학교
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