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Gut and Liver update

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수록범위 : 1권1호(2007)~13권3호(2019) |수록논문 수 : 1,156
Gut and Liver
13권3호(2019년 05월) 수록논문
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KCI등재 SCI SCOPUS

1Which Needle Needs to Be Chosen for Better Outcome of Endoscopic Ultrasound-Guided Tissue Acquisition?

저자 : Dong Wook Lee , Eun Young Kim

발행기관 : 대한간학회 간행물 : Gut and Liver 13권 3호 발행 연도 : 2019 페이지 : pp. 223-224 (2 pages)

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KCI등재 SCI SCOPUS

2Developing Consilience Medicine: Positron Emission Tomography Scan and Transcriptomics in Pancreatic Cancer

저자 : Seong Hun Kim , Seung Ok Lee

발행기관 : 대한간학회 간행물 : Gut and Liver 13권 3호 발행 연도 : 2019 페이지 : pp. 225-226 (2 pages)

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32018 Korean Liver Cancer Association-National Cancer Center Korea Practice Guidelines for the Management of Hepatocellular Carcinoma

저자 : 대한간학회

발행기관 : 대한간학회 간행물 : Gut and Liver 13권 3호 발행 연도 : 2019 페이지 : pp. 227-290 (64 pages)

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Hepatocellular carcinoma (HCC) is the fifth most common cancer globally and the fourth most common cancer in men in Korea, where the prevalence of chronic hepatitis B infection is high in middle-aged and elderly patients. These practice guidelines will provide useful and constructive advice for the clinical management of patients with HCC. A total of 44 experts in hepatology, oncology, surgery, radiology and radiation oncology in the Korean Liver Cancer Association-National Cancer Center Korea Practice Guideline Revision Committee revised the 2014 Korean guidelines and developed new recommendations that integrate the most up-to-date research findings and expert opinions. (Gut Liver 2019;13:227-299)

KCI등재 SCI SCOPUS

4IgG4-Related Sclerosing Cholangitis and Primary Sclerosing Cholangitis

저자 : Atsushi Tanaka

발행기관 : 대한간학회 간행물 : Gut and Liver 13권 3호 발행 연도 : 2019 페이지 : pp. 300-307 (8 pages)

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Sclerosing cholangitis (SC) is defined as a condition with progressive stenosis and destruction of the bile ducts due to diffuse inflammation and fibrosis and currently includes three categories: primary sclerosing cholangitis (PSC), secondary cholangitis, and IgG4-related sclerosing cholangitis (IgG4-SC). SC categories share similar clinical features, such as cholestasis. Patients with SC present with cholestatic symptoms, including jaundice and pruritus, and blood tests reveal elevation of cholestatic enzymes. Cholangiography, endoscopic or magnetic, is inevitably required for making a diagnosis. Although the presentation of IgG4-SC and PSC are similar, the comorbidities, treatment response, and outcomes differ significantly, and therefore, it is strongly advisable to be familiar with these two diseases to make a correct diagnosis. Differentiation of cholangiocarcinoma from IgG4-SC and PSC is also extremely important. In this review, the clinical characteristics, comorbidities, treatment and outcomes of IgG4-SC and PSC will be outlined based on experience mainly from Japan. (Gut Liver 2019;13:300-307)

KCI등재 SCI SCOPUS

5Effects of Moderate Alcohol Drinking in Patients with Nonalcoholic Fatty Liver Disease

저자 : Inbeom Kwon , Dae Won Jun , Jin-hwa Moon

발행기관 : 대한간학회 간행물 : Gut and Liver 13권 3호 발행 연도 : 2019 페이지 : pp. 308-314 (7 pages)

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Whether moderate alcohol intake is beneficial remains an unsolved issue. Recent studies have suggested that moderate alcohol consumption is associated with beneficial effects related to the prevention of cardiovascular diseases. Moderate alcohol consumption leads to a higher risk of hepatocellular carcinoma in patients with chronic viral liver diseases. However, the effects of moderate alcohol intake in patients with nonalcoholic fatty liver disease are unclear. In this review, we analyzed, from various perspectives, the effect of moderate alcohol consumption in patients with nonalcoholic fatty liver disease. We reviewed four cohort studies and seven cross-sectional studies. The results showed that moderate alcohol consumption was negatively related to the incidence of nonalcoholic steatohepatitis and liver fibrosis. However, moderate alcohol consumption was positively associated with the incidence of hepatocellular carcinoma in patients with nonalcoholic fatty liver disease. The results of the analysis of the relationship between moderate alcohol consumption and the levels of triglycerides, total cholesterol, high-density lipoprotein, and hypertension were diverse. More clinical data are needed to draw a conclusion about the effects of moderate alcohol consumption in patients with nonalcoholic fatty liver disease. (Gut Liver 2019;13:308-314)

KCI등재 SCI SCOPUS

6Management of Clinical T1N0M0 Esophageal Cancer

저자 : Andrew J. Yang , Seo Hee Choi , Hwa Kyung Byun , Hyun Ju Kim , Jinhyun Choi , Yong Chan Lee , Sang Kil Lee , Kyung Ran Park , Chang Geol Lee

발행기관 : 대한간학회 간행물 : Gut and Liver 13권 3호 발행 연도 : 2019 페이지 : pp. 315-324 (10 pages)

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Background/Aims: Endoscopic resection is a standard treatment for stage T1a esophageal cancer, with esophagectomy or radical radiation therapy (RT) performed for stage T1b lesions. This study aimed to compare treatment outcomes of each modality for clinical stage T1 esophageal cancer. Methods: In total, 179 patients with clinical T1N0M0-stage esophageal cancer treated from 2006 to 2016 were retrospectively evaluated. Sixty-two patients with clinical T1a-stage cancer underwent endoscopic resection. Among 117 patients with clinical T1b-stage cancer, 82 underwent esophagectomy, and 35 received chemoradiotherapy or RT. We compared overall survival (OS) and recurrence-free survival (RFS) rates for each treatment modality. Results: The median follow-up time was 32 months (range, 1 to 120 months). The 5-year OS and RFS rates for patients with stage T1a cancer receiving endoscopic resection were 100% and 85%, respectively. For patients with stage T1b, the 5-year OS and RFS rates were 78% and 77%, respectively, for the esophagectomy group; 80% and 44%, respectively, for the RT alone group; and 96% and 80%, respectively, for the chemoradiation group. The esophagectomy group showed significantly higher RFS than the RT alone group (p=0.04). There was no significant difference in RFS between the esophagectomy and chemoradiation groups (p=0.922). Grade 4 or higher treatment-related complications occurred in four patients who underwent esophagectomy. Conclusions: Endoscopic resection appeared to be an adequate treatment for patients with T1a-stage esophageal cancer. The multidisciplinary approach involving chemoradiation was comparable to esophagectomy in terms of survival outcome without serious complications for T1b-stage esophageal cancer. (Gut Liver 2019;13:315-324)

KCI등재 SCI SCOPUS

7Depression Promotes the Onset of Irritable Bowel Syndrome through Unique Dysbiosis in Rats

저자 : Takeshi Takajo , Kengo Tomita , Hanae Tsuchihashi , Shingo Enomoto , Masaaki Tanichi , Hiroyuki Toda , Yoshikiyo Okada , Hirotaka Furuhashi , Nao Sugihara , Akinori Wada , Kazuki Horiuchi , Kenichi Inaba ,

발행기관 : 대한간학회 간행물 : Gut and Liver 13권 3호 발행 연도 : 2019 페이지 : pp. 325-332 (8 pages)

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Background/Aims: Although studies using conventional animal models have shown that specific stressors cause irritable bowel syndrome (IBS), it is unclear whether depression itself causes IBS. Our aim was to establish a rat model to determine if depression itself promotes the onset of IBS and to elucidate the role of gut microbiota in brain-gut axis pathogenesis during coincident depression and IBS. Methods: Rat models of depression were induced using our shuttle box method of learned helplessness. Visceral hypersensitivity was evaluated by colorectal distension (CRD) to diagnose IBS. Gut microbiota compositions were analyzed using high-throughput sequencing. In the subanalysis of rats without depression-like symptoms, rats with posttraumatic stress disorder (PTSD) were also examined. Results: The threshold value of CRD in depressed rats was significantly lower than that in control rats. Microbial community analysis of cecal microbiota showed that the relative abundance of Clostridiales incertae sedis, the most prevalent microbe, was significantly lower in depressed rats than in control rats. The distribution pattern of the microbiota clearly differed between depressed rats and control rats. Neither visceral hypersensitivity nor the composition of gut microbiota was altered in rats with PTSD-like phenotypes. Conclusions: Our rat model of depression is useful for clarifying the effect of depression on IBS and suggests that depression itself, rather than specific stressors, promotes the onset of IBS. Further, we provided evidence that various psychiatric diseases, viz., depression and PTSD, are associated with unique gut microbiota profiles, which could differentially affect the onset and progression of coincident IBS. (Gut Liver 2019;13:325-332)

KCI등재 SCI SCOPUS

8Increased Risk of Herpes Zoster in Young and Metabolically Healthy Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Study

저자 : Hosim Soh , Jaeyoung Chun , Kyungdo Han , Seona Park , Gukhwan Choi , Jihye Kim , Jooyoung Lee , Jong Pil Im , Joo Sung Kim

발행기관 : 대한간학회 간행물 : Gut and Liver 13권 3호 발행 연도 : 2019 페이지 : pp. 333-341 (9 pages)

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Background/Aims: The risk of herpes zoster (HZ) among patients with inflammatory bowel disease (IBD) remains unclear in terms of age and metabolic comorbidities, including diabetes mellitus, hypertension, or dyslipidemia. We conducted a nationwide population-based study to investigate the risk of HZ in patients with IBD. Methods: From 2010 to 2013, a retrospective study was performed using claims data in Korea. We compared the incidence of HZ between 30,100 IBD patients (10,517 Crohn's disease [CD] and 19,583 ulcerative colitis [UC] patients) and 150,500 non-IBD controls matched by age and sex. Results: During a mean follow-up of 5.0 years, incidence rates of HZ (per 1,000 person-years) were 13.60, 14.99, and 9.19 in the CD, UC, and control groups, respectively. The risk of HZ was significantly higher in patients with CD (adjusted hazard ratio [HR], 2.13; p<0.001) and UC (adjusted HR, 1.40; p<0.001) than in the controls. The impact of CD on developing HZ was significantly more prominent in younger patients (adjusted HR, 2.61 for age <15, whereas 1.39 for age ≥60; interaction p=0.001) and in patients without metabolic comorbidities (adjusted HR, 2.24, whereas 1.59 in those with metabolic comorbidities; interaction p=0.015). Moreover, the impact of UC on developing HZ significantly increased in younger patients (adjusted HR, 2.51 in age <15, whereas 1.22 in age ≥60; interaction p=0.014) and patients without metabolic comorbidities (adjusted HR, 1.49 whereas 1.16 in those with metabolic comorbidities; interaction p<0.001). Conclusions: IBD was associated with an increased risk of HZ, especially in younger patients without metabolic comorbidities. (Gut Liver 2019;13:333-341)

KCI등재 SCI SCOPUS

9Stem Cell Markers Predict the Response to Sorafenib in Patients with Hepatocellular Carcinoma

저자 : Bo Hyun Kim , Joong-won Park , Jin Sook Kim , Sook-kyung Lee , Eun Kyung Hong

발행기관 : 대한간학회 간행물 : Gut and Liver 13권 3호 발행 연도 : 2019 페이지 : pp. 342-348 (7 pages)

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Background/Aims: Sorafenib remains the only approved molecular targeted agent for hepatocellular carcinoma (HCC); however, reliable biomarkers that predict its efficacy are still lacking. The aim of this study was to explore whether cancer stem cell (CSC) markers have a predictive role with regard to the sorafenib response in HCC patients. Methods: We enrolled 47 patients with HCC for whom tumor samples obtained before starting sorafenib treatment were available. RNA was extracted from formalin-fixed, paraffin-embedded samples, and real-time polymerase chain reaction was used to quantify mRNA expression of the CSC genes EpCAM , CD13, CK8, CD24, CD44, CD90, CD133, SALL4, ALDH1A1, ALB , and AFP . Results: Of 47 patients, 14.9% and 74.5% had vascular invasion and extrahepatic spread, respectively. Patients with low CD133 expression tended to have longer progression-free survival (PFS) than those with high CD133 expression (5.5 months vs 4.0 months), although without statistical significance. The expression levels of other markers were not associated with PFS. When examining markers in combination, patients with high CD133 and CD90 expression had shorter PFS rates than those with low expression (2.7 months vs 5.5 months; p=0.04). Patients with low CD133 and EpCAM expression demonstrated better PFS than those with high expression (7.0 months vs 4.2 months; p=0.04). Multivariable analysis indicated that an Eastern Cooperative Oncology Group performance status score of 1 and high CD133/CD90 expression were significantly associated with shorter PFS. Conclusions: Overexpression of the CSC markers CD133 and CD90 in HCC was associated with poorer response to sorafenib. These two genes may serve as predictive biomarkers for sorafenib therapy. (Gut Liver 2019;13:342-348)

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10Comparison of the Diagnostic Yield of the Standard 22-Gauge Needle and the New 20-Gauge Forward-Bevel Core Biopsy Needle for Endoscopic Ultrasound-Guided Tissue Acquisition from Pancreatic Lesions

저자 : Shinya Fujie , Hirotoshi Ishiwatari , Keiko Sasaki Junya Sato , Hiroyuki Matsubayashi , Masao Yoshida , Sayo Ito , Noboru Kawata , Kenichiro Imai , Naomi Kakushima , Kohei Takizawa , Kinichi Hotta , Hiroyuki On

발행기관 : 대한간학회 간행물 : Gut and Liver 13권 3호 발행 연도 : 2019 페이지 : pp. 349-355 (7 pages)

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Background/Aims: To compare the diagnostic yield of 20-gauge forward-bevel core biopsy needle (CBN) and 22-gauge needle for endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) of solid pancreatic masses. Methods: The use of 20-gauge CBN was prospectively evaluated for 50 patients who underwent EUS-FNA from June 2016 to December 2016. Data were compared with those obtained by a retrospective study of 50 consecutive patients who underwent EUS-FNA using standard 22-gauge needles between December 2016 and April 2017. At least two punctures were performed for each patient; the sample from the first pass was used for cytology with or without histology and that from the second pass was used for histology. Sample quantity was evaluated using the sample obtained from the second pass. Results: There was no significant difference in the diagnostic accuracy rate between the first and second passes (20-gauge CBN: 96% [48/50]; standard 22-gauge needle: 88% [44/50]). Samples >10× power fields in length were obtained from 90% (43/48) and 60% (30/50) of patients using the 20-gauge CBN and standard 22-gauge needle, respectively (p=0.01). Technical failure occurred for two patients with the 20-gauge CBN. Conclusions: Diagnostic accuracy of the 20-gauge CBN was comparable to that of the 22-gauge needle. However, two passes with the 20-gauge CBN yielded a correct diagnosis for 100% of patients when technically feasible. Moreover, the 20-gauge CBN yielded core tissue for 90% patients, which was a performance superior to that of the 22-gauge needle. (Gut Liver 2019;13:349-355)

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