간행물

대한소화기학회> Gut and Liver

Gut and Liver update

  • : 대한소화기학회
  • : 의약학분야  >  내과학
  • : KCI등재
  • : SCI,SCOPUS
  • : 연속간행물
  • : 격월
  • : 1976-2283
  • :
  • :

수록정보
수록범위 : 1권1호(2007)~12권6호(2018) |수록논문 수 : 1,110
Gut and Liver
12권6호(2018년 11월) 수록논문
최근 권호 논문
| | | |

KCI등재 SCI SCOPUS

1Weight Management as a Treatment Option for Gastroesophageal Reflux Disease: A Mechanical or Metabolic Rescuer?

저자 : Hyuk Lee

발행기관 : 대한소화기학회 간행물 : Gut and Liver 12권 6호 발행 연도 : 2018 페이지 : pp. 607-608 (2 pages)

다운로드

(기관인증 필요)

키워드 보기
초록보기

다운로드

(기관인증 필요)

키워드 보기
초록보기

KCI등재 SCI SCOPUS

3The Choice of Interventional Treatment of Gastric Variceal Hemorrhage: What Is Better?

저자 : Moon Young Kim

발행기관 : 대한소화기학회 간행물 : Gut and Liver 12권 6호 발행 연도 : 2018 페이지 : pp. 611-612 (2 pages)

다운로드

(기관인증 필요)

키워드 보기
초록보기

KCI등재 SCI SCOPUS

4The More, the Better? Predicting Prognosis in Primary Biliary Cholangitis

저자 : Bo Hyun Kim

발행기관 : 대한소화기학회 간행물 : Gut and Liver 12권 6호 발행 연도 : 2018 페이지 : pp. 613-614 (2 pages)

다운로드

(기관인증 필요)

키워드 보기
초록보기

KCI등재 SCI SCOPUS

5A Program to Treat Hepatitis B in North Korea: A Model of Antiviral Therapy in a Resource-Poor Setting

저자 : Alice Unah Lee , Heidi Linton , Marcia Kilsby , David C. Hilmers

발행기관 : 대한소화기학회 간행물 : Gut and Liver 12권 6호 발행 연도 : 2018 페이지 : pp. 615-622 (8 pages)

다운로드

(기관인증 필요)

초록보기

Despite the well-proven, safe and effective therapies for hepatitis B infection, delivery of treatment remains a significant challenge in resource-poor settings. Geopolitical and economic restrictions present additional difficulties in providing care in North Korea. However, treatment of patients with chronic hepatitis B remains a top priority for both the North Korean Ministry of Public Health and international agencies working in North Korean hepatitis healthcare facilities. Working in partnership, a path was created to institute this much-needed program. A consortium of United States and Australian humanitarian non-governmental organizations along with generous individual and corporate donors working in concert with local and national health authorities have succeeded in establishing the first hepatitis B treatment program in North Korea. The essential elements of this program include renovation of existing hepatitis hospitals, access to antiviral medications, establishment of laboratory facilities, creation of medical documentation and record-keeping, training of local health care professionals, and quarterly visits by international volunteer physicians and laboratory experts. Management and treatment decisions are made bilaterally. To date, nearly 1,500 patients have been evaluated, and over 800 have been started on long-term antiviral therapy. It is envisioned that this program will eventually be managed and funded by the Democratic People's Republic of Korea Ministry of Public Health. This program's success demonstrates a potential model for delivery of antiviral therapy for patients suffering from hepatitis B in other developing countries. (Gut Liver 2018;12:615-622)

KCI등재 SCI SCOPUS

6Anti-Tumor Necrosis Factor Therapy in Intestinal Behcet's Disease

저자 : Jihye Park , Jae Hee Cheon

발행기관 : 대한소화기학회 간행물 : Gut and Liver 12권 6호 발행 연도 : 2018 페이지 : pp. 623-632 (10 pages)

다운로드

(기관인증 필요)

초록보기

Intestinal Behcet's disease is a rare, immune-mediated chronic intestinal inflammatory disease; therefore, clinical trials to optimize the management and treatment of patients are scarce. Moreover, intestinal Behcet's disease is difficult to treat and often requires surgery because of the failure of conventional medical treatment. Administration of anti-tumor necrosis factor-α, a potential therapeutic strategy, is currently under active clinical investigation, and evidence of its effectiveness for both intestinal Behcet's disease and inflammatory bowel diseases has been accumulating. Here, we review updated data on current experiences and outcomes after the administration of anti-tumor necrosis factor-α for the treatment of intestinal Behcet's disease. In addition to infliximab and adalimumab, which are the most commonly used agents, we describe agents such as golimumab, etanercept, and certolizumab pegol, which have recently been shown to be effective in refractory intestinal Behcet's disease. This review also discusses safety issues associated with anti-tumor necrosis factor-α, including vulnerability to infections and malignancy. (Gut Liver 2018;12:623-632)

KCI등재 SCI SCOPUS

7Weight Loss as a Nonpharmacologic Strategy for Erosive Esophagitis: A 5-Year Follow-up Study

저자 : Ki Bae Bang , Jung Ho Park

발행기관 : 대한소화기학회 간행물 : Gut and Liver 12권 6호 발행 연도 : 2018 페이지 : pp. 633-640 (8 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aims: Obesity is a risk factor for gastroesophageal reflux disease (GERD), with several studies demonstrating positive associations between body mass index (BMI) and GERD symptoms. However, little is known about the effect of BMI changes on erosive esophagitis (EE). In this study, we investigated whether BMI reduction could resolve EE. Methods: A retrospective cohort study was performed to assess the natural course of EE according to changes in BMI. Participants undergoing health check-ups from 2006 to 2012 were enrolled, and 1,126 subjects with EE were included. The degree of esophagitis was measured by upper endoscopy and serially checked over a 5-year follow-up. Logistic regression and Cox proportional hazards models were used to investigate the association between BMI reduction and EE resolution. Results: Substantial weight loss is associated with EE resolution. The adjusted odds ratio for EE resolution was 1.44 (95% confidence interval [CI], 1.09 to 1.92) among participants with a decrease in BMI compared to those with no decrease in BMI. The EE resolution rate was related to the degree of BMI reduction. The effect of weight loss on EE resolution was higher among subjects who lost more weight. Compared with subjects with no decrease in BMI, the hazard ratios for EE resolution were 1.09 (95% CI, 0.89 to 1.35), 1.31 (95% CI, 1.01 to 1.72) and 2.12 (95% CI, 1.44 to 3.12) in subjects with BMI reductions of ≤1, 1-2, and >2 kg/㎡, respectively. Conclusions: EE resolution is associated with a decrease in BMI, and weight loss is potentially an effective GERD treatment. (Gut Liver 2018;12:633-640)

KCI등재 SCI SCOPUS

8Peptide Nucleic Acid Probe-Based Analysis as a New Detection Method for Clarithromycin Resistance in Helicobacter pylori

저자 : Da Hyun Jung , Jie-hyun Kim , Su Jin Jeong , Soon Young Park , Il-mo Kang , Kyoung Hwa Lee , Young Goo Song

발행기관 : 대한소화기학회 간행물 : Gut and Liver 12권 6호 발행 연도 : 2018 페이지 : pp. 641-648 (8 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aims: Helicobacter pylori eradication rates are decreasing because of increases in clarithromycin resistance. Thus, finding an easy and accurate method of detecting clarithromycin resistance is important. Methods: We evaluated 70 H. pylori isolates from Korean patients. Duallabeled peptide nucleic acid (PNA) probes were designed to detect resistance associated with point mutations in 23S ribosomal ribonucleic acid gene domain V (A2142G, A2143G, and T2182C). Data were analyzed by probe-based fluorescence melting curve analysis based on probe-target dissociation temperatures and compared with Sanger sequencing. Results: Among 70 H. pylori isolates, 0, 16, and 58 isolates contained A2142G, A2143G, and T2182C mutations, respectively. PNA probe-based analysis exhibited 100.0% positive predictive values for A2142G and A2143G and a 98.3% positive predictive value for T2182C. PNA probe-based analysis results correlated with 98.6% of Sanger sequencing results (κ-value=0.990; standard error, 0.010). Conclusions: H. pylori clarithromycin resistance can be easily and accurately assessed by dual-labeled PNA probe-based melting curve analysis if probes are used based on the appropriate resistance-related mutations. This method is fast, simple, accurate, and adaptable for clinical samples. It may help clinicians choose a precise eradication regimen. (Gut Liver 2018;12:641-647)

KCI등재 SCI SCOPUS

9An Economic Modeling Study of Helicobacter pylori Eradication: Comparison of Dual Priming Oligonucleotide-Based Multiplex Polymerase Chain Reaction and Empirical Treatment

저자 : Tae-geun Gweon , Joon Sung Kim , Byung-wook Kim

발행기관 : 대한소화기학회 간행물 : Gut and Liver 12권 6호 발행 연도 : 2018 페이지 : pp. 648-654 (7 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aims: Dual priming oligonucleotide-based multiplex polymerase chain reaction (DPO-based PCR) can detect the presence of clarithromycin resistance without culture. The aim of this study was to investigate the cost-effectiveness of DPO-based PCR for Helicobacter pylori eradication. Methods: From 2015 to 2016, medical records of patients who received H. pylori eradication therapy were analyzed. Patients were divided into two groups: tailored group patients who were treated based on DPO-based PCR and empirical group patients. Eradication rate and medical cost, including diagnostic tests, eradication regimens, and 13C-urea breath tests, were compared between the two groups. Cost for one successful eradication was calculated in each group. The expected cost of eradication for empirical treatment was investigated by varying the treatment duration and eradication rate. Results: A total of 527 patients were analyzed (tailored group 208, empirical group 319). The eradication success rate of the first-line therapy was higher in the tailored group compared to that in the empirical group (91.8% vs 72.1%, p<0.01). The total medical cost for each group was 114.8±14.1 U.S. dollars (USD) and 85.8±24.4 USD, respectively (p<0.01). The total medical costs for each ultimately successful eradication in the tailored group and in the empirical group were 120.0 USD and 92.4 USD, respectively. The economic modeling expected cost of a successful eradication after a 7- or 14-day empirical treatment was 93.8 to 111.4 USD and 126.3 to 149.9 USD, respectively. Conclusions: Based on economic modeling, the cost for a successful eradication using DPO-based PCR would be similar or superior to the expected cost of a successful eradication with a 14-day empirical treatment when the first-line eradication rate is ≤80%. (Gut Liver 2018;12:648-654)

KCI등재 SCI SCOPUS

10Optimal Starting Age for Colorectal Cancer Screening in an Era of Increased Metabolic Unhealthiness: A Nationwide Korean Cross-Sectional Study

저자 : Yoon Jin Choi , Dong Ho Lee , Kyung-do Han , Hyun Soo Kim , Hyuk Yoon , Cheol Min Shin , Young Soo Park , Nayoung Kim

발행기관 : 대한소화기학회 간행물 : Gut and Liver 12권 6호 발행 연도 : 2018 페이지 : pp. 655-666 (12 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aims: The association between metabolic syndrome and colorectal cancer (CRC) has been suggested as one of causes for the increasing incidence of CRC, particularly in younger age groups. The present study examined whether the current age threshold (50 years) for CRC screening in Korea requires modification when considering increased metabolic syndrome. Methods: We analyzed data from the National Health Insurance Corporation database, which covers ~97% of the population in Korea. CRC risk was evaluated with stratification based on age and the presence/absence of relevant metabolic syndrome components (diabetes, dyslipidemia, and hypertension). Results: A total of 51,612,316 subjects enrolled during 2014 to 2015 were analyzed. Among them, 19.3% had diabetes, hypertension, dyslipidemia, or some combination thereof. This population had a higher incidence of CRC than did those without these conditions, and this was more prominent in subjects <40 years of age. The optimal cutoff age for detecting CRC, based on the highest Youden index, was 45 years among individuals without diabetes, dyslipidemia, and hypertension. Individuals with at least one of these components of metabolic syndrome had the highest Youden index at 62 years old, but the value was only 0.2. Resetting the cutoff age from 50 years to 45 years achieved a 6% increase in sensitivity for CRC detection among the total population. Conclusions: Starting CRC screening earlier, namely, at 45 rather than at 50 years of age, may improve secondary prevention of CRC in Korea. (Gut Liver 2018;12:655-663)

12
권호별 보기
가장 많이 인용된 논문

(자료제공: 네이버학술정보)

가장 많이 인용된 논문
| | | |
1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

다운로드

2미국의 비트코인 규제

(2006)홍길동심리학41회 피인용

다운로드

가장 많이 참고한 논문

(자료제공: 네이버학술정보)

가장 많이 참고한 논문

다운로드

2미국의 비트코인 규제

(2006)홍길동41회 피인용

다운로드

해당 간행물 관심 구독기관

인제대학교 중앙대학교(서울) 원광대학교 부산대학교 지방보훈병원
 7
 1
 1
 1
 1
  • 1 인제대학교 (7건)
  • 2 중앙대학교(서울) (1건)
  • 3 원광대학교 (1건)
  • 4 부산대학교 (1건)
  • 5 지방보훈병원 (1건)
  • 6 University of Toronto (1건)
  • 7 충남대학교 (1건)

내가 찾은 최근 검색어

최근 열람 자료

맞춤 논문

보관함

내 보관함
공유한 보관함

1:1문의

닫기