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The Journal of Applied Oriental Medicine

  • : 한약응용학회
  • : 의약학분야  >  기초한의학
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  • : 연속간행물
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  • : 1598-5539
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수록정보
수록범위 : 1권1호(2001)~19권1호(2019) |수록논문 수 : 168
한약응용학회지
19권1호(2019년 12월) 수록논문
최근 권호 논문
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1葛根(갈근)의 鮮用(선용), 生用(생용)과 炮製用(포제용)에 관한 문헌적 고찰

저자 : 오양팡란 ( Ouyang Fang-lan )

발행기관 : 한약응용학회 간행물 : 한약응용학회지 19권 1호 발행 연도 : 2019 페이지 : pp. 1-8 (8 pages)

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Puerariae Lobatae Radix is in use in the Korean medicina. The Korean medical doctors use PLR for solution of muscle defervescence(解肌退熱), help produce saliva and slake thirst(生津止渴), Promoting eruption(透疹), promoting spleen yang and stopping antidiarrheal (升陽止瀉), clearing and activating the channels and collaterals(通經活絡),eliminating toxin (解毒)etc. I investigated about fresh use,crude use and processed us of Puerariae Lobatae Radix.

2고지방 식이로 유발한 마우스 동물모델에서 제조법을 달리한 보이차 추출물이 지질대사 및 항산화에 미치는 영향

저자 : 박소윤 ( So Yun Park ) , 서부일 ( Bu-il Seo )

발행기관 : 한약응용학회 간행물 : 한약응용학회지 19권 1호 발행 연도 : 2019 페이지 : pp. 9-25 (17 pages)

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Objectives : The aim of this study was investigate an antioxidative activities effects of raw ethanol extracts and fermented ethanol extracts of pu-erh tea (Camellia sinensis L.).
Methods : The 6 kinds of raw pu-erh tea and 6 kinds of fermented pu-erh tea was prepared 24 hours by stirrer extraction with 30% ethanol. The antioxidant activities were evaluated through radical scavenging assays using 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH). Also, examined total poly phenol and flavonoids contents. The most outstanding pu-erh tea was used to measure pancreatic lipase and lipid metabolism in high-fat diet induced mice model.
Results : The antioxidant effects of raw pu-erh tea and fermented pu-erh tea were investigated and the following results were obtained. The total polyphenol contents of 6 kinds of raw pu-erh tea was 23.41±0.06 ㎎/g (imuyasaeng), 25.41±0.04 (imugwalpungchae), 31.99±0.10 (musangmyomi), 34.54±0.29 (gojingamlae), 33.28±0.30 (gosan-yeong-a), 30.75±0.06 (baosan). and 6 kinds of fermented pu-erh tea was 10.07±0.08 ㎎/g (polangsan), 7.77±0.04 (imugyomog), 10.35±0.04 (banjang-eunho), 7.98±0.06 (namnasan), 10.77±0.05 (gungjeongboi), 10.89±0.04 (donghai3geub). The total polyphenol contents of raw pu-erh tea was higher than fermented pu-erh tea.
Conclusion : pu-erh tea extracts has a excellent effect on antioxidant in in vitro, and raw pu-erh tea extract have a better effect on high-fat diet induced mice through antioxidant and lipid metabolism.

3韓國産(한국산) 느릅나무科(과)(Ulmaceae. 楡科(유과)) 植物(식물)에 關(관)한 本草學的(본초학적) 硏究(연구)와 部位別(부위별) 食用用途(식용용도)

저자 : 주시찬 ( Si Chan Joo ) , 손영숙 ( Young Sook Son )

발행기관 : 한약응용학회 간행물 : 한약응용학회지 19권 1호 발행 연도 : 2019 페이지 : pp. 27-49 (23 pages)

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Objective : For the development of Korean herbology and Sitology Through Korean Ulmaceous plant research, the literature of the successive generations have been exhaustively investigated for this article.
Method : In the field of herbology and Sitology, Internal and external Publications-Books, Online Journals, Off-line Journals-were examined.
Result : In this study, we make a list about Korean Wild Plants of Ulmaceae after domestic and foreign Ulmaceae literature investigation. On the bases of this list, First, Useful plants of Ulmaceae were selected and their habitat range were analyzed. The parts of Selected plant, which can be used as a medicine, were classified according to various categories-oriental medicine name, scientific name, non-official name-, noted Ulmaceae properties such as flavor, chammels they use, effects, Chief virtue, pharmacological action. Second, ediable plants of Ulmaceae were selected and noticed their edibility purpose to each part. Korean Ulmaceae were divided into 5 classes with 18 species, Of that, 9 species were found medically usable, 10 species were found ediable. In 9 medically usable plants, valuable part of plants were classified 8 rhizodermis, 7 cortexes, 5 leaves. these plants were identified to various features, include 8 Non-toxic plant, such as flatness drug, spicy taste, Diuretic diuresis, Detumescence, Detoxification, In 10 ediable plants, valuable part of plants were classified 5 immature leaves, 4 fruits 3 cortexes, etc. These plants were used for Korean Rice cake, Rescue plant, Soup, Noodles, fruit as well.
Conclusion : Korean wild Ulmaceous plant toxonomically divided into 5 classes with 18 species and 9 species used for medicine, 10 species used for food, as a result, Korean wild Ulmaceous plant were used as herbological medicine and Sitological food either.

4장구채 전초와 맥람채 종자의 약리효능 및 성분에 관한 고찰

저자 : 배혜경 ( Hye Kyung Bae )

발행기관 : 한약응용학회 간행물 : 한약응용학회지 19권 1호 발행 연도 : 2019 페이지 : pp. 51-61 (11 pages)

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Objectives : The present study purposed to compare the effects of Melandrii Herba and Vaccariae Semen, which are used as Wang-Bul-Yu-Haeng(王不留 行) in Korea and China. In this review, we provide a summary of the latest pharmacological efficacy and clinical study of Melandrii Herba and Vaccariae Semen.
Methods : All experiment papers on the Melandrii Herba and Vaccariae Semen has been searched with the keyword in the internet sites like RISS, NDSL, etc., and then they are analyzed on the basis of the effective classification of pharmacological efficacy and clinical study.
Results & Conclusion : In view of the fact that Wang-Bul-Yu-Haeng is used as an efficacy of to keep the blood flowing smoothly in clinical practice, most of the studies have been conducted based on the hypertensive activity from studies on hyperlipemia, extravasated blood, anti-inflammation on the viewpoint of oriental medicine. The results of comparative analysis of the outbreaks of Melandrii herba and Vaccariae semen showed that both had to kept the blood flowing smoothly. Moreover the Vaccariae semen showed better efficacy than the Melandrii herba. However, the fact that the origin of medicinal herbs which are currently used in the Wang-Bul-Yu-Haeng has not been clarified, and the differences in the effects of medicinal products have also been insufficient. It suggests that necessary to study the origin of the plant and to clarify the origins of the plants according to their respective efficacy.

5치자, 오배자 추출물이 함유된 마스크 시트의 항산화 · 항균 효과

저자 : 김부진 ( Bu Jin Kim ) , 서화진 ( Hwa-jin Suh ) , 권오운 ( Oh Oun Kwon ) , 노성수 ( Seong-soo Roh )

발행기관 : 한약응용학회 간행물 : 한약응용학회지 19권 1호 발행 연도 : 2019 페이지 : pp. 63-71 (9 pages)

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Objectives : Other than the traditional uses as the natural coloring matters, the gardenia seeds and the gallnuts have been used as the materials for the foods and the Oriental medicines. And, recently, as the naturally-derived substances, they have been utilized in the diverse fields. Although, regarding most of the natural dyes which are tinged with the colors, because they abundantly possess the polyphenol and the useful, secondary metabolites, they have the antioxidation and anti-bacterial efficacy, because the colorings of the skin and the stabilities of the materials are low, there are the difficulties with regard to the use. In this research, by using the gall nuts and the gardenia seeds, the research had been conducted for the verification of the efficacy as the cosmetic product materials, for the durability of the naturally-dyed, non-woven fabric, and for the production of an anti-bacterial, non-woven fabric.
Methods : In order to secure the visual beauty and the functional aspect, the gall nut and the gardenia seeds had been used as the complex extracts.
Results : Their anti-oxidant activities were analyzed to be 22.5/9.3 ㎍/㎖, respectively, regarding the DPPH/ABTS. And the inhibition (IC50, 11.3 ㎍/㎖) of the tyrosinase activity was, also, analyzed to be on a high level. This was excellent to the extent that it was comparable to the ascorbid acid, which had been used for the positive control. Not only that, regarding the anti-inflammatory efficacy and the anti-bacterial effect, too, the result on a far higher level compared to the other extracts was obtained.
Conclusion : In the light of such results, it is judged that there are a lot of the utilizations of the natural dye materials for making the raw, cosmetic product materials. And it is thought that, by carrying out the in-depth clinical researches at the same time, it will be able to be applied as a material with the safe and excellent efficacy.

6고지방식이로 유발된 이상지질혈증 동물모델에서 決明子(결명자) 에탄올 추출물의 개선 효과

저자 : 백선재 ( Seon-jae Baek ) , 노성수 ( Seong-soo Roh ) , 박지하 ( Ji-ha Park ) , 구진숙 ( Jin Suk Koo ) , 서부일 ( Bu-il Seo )

발행기관 : 한약응용학회 간행물 : 한약응용학회지 19권 1호 발행 연도 : 2019 페이지 : pp. 73-86 (14 pages)

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Objectives : Dyslipidemia has recently become an important social burden for public health. Therefore, the aim of this study was to investigate improvement effects of Cassia semen (CS) on dyslipidemia mouse model induced by high-fat diet.
Methods : The antioxidant activity and the inhibitory effect of pancreatic lipase were evaluated by in vitro assays. Experimental animals were divided into 3 groups; Control group, CS200 group and CS400 group. All groups were supplied high-fat diet for inducing dyslipidemia. During the experimental period, CS200 group and CS400 group were administrated CS extract at dose of 200 and 400 mg/kg/day, respectively. The changes of reactive oxygen species (ROS), peroxynitrite (ONOO-), triglyceride (TG), total cholesterol (TC), High-density lipoprotein cholesterol (HDL-C) and Low-density lipoprotein cholesterol (LDL-C) in serum were analyzed.
Results : The antioxidant capacity of CS was evaluated and its IC50 were 25.91 ㎍/㎖ for DPPH and 54.41 ㎍/㎖ for ABTS. Total phenol and total flavonoid of CS were 35.89 and 35.38 ㎎/g, respectively. Also, CS inhibited pancreatic lipase activity in a concentration-dependant manner. In dyslipidemia mouse model, the administration of CS was decreased body weight gain and the weight of epididymal fat. Moreover, CS administration suppressed the levels of ROS, ONOO-, TG, TC, and LDL-C in serem. On the contraty, serum HDL-C level was increased by CS administration.
Conclusion : In conclusion, these results support that CS may possess a therapeutic effect on dyslipidemia via antioxidant activity and pancreatic lipase inhibitory activity.

7길경의 경북 산지별 유효성분 비교 및 안전성 평가

저자 : 최해심 ( Hae Sim Choi ) , 김연수 ( Yeon-soo Kim ) , 황보민 ( Min Hwangbo ) , 지선영 ( Seon-young Jee )

발행기관 : 한약응용학회 간행물 : 한약응용학회지 19권 1호 발행 연도 : 2019 페이지 : pp. 87-97 (11 pages)

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Backgrounds : The quality of Platycodi Radix was compared and assessed according to regions cultivated in Gyeongbuk. The primary component, safety assessment, and residual pesticides of Platycodi Radix related to production regions in Gyeongbuk are currently unknown. Objective : The aim of this study is to compare and evaluate effective constituent and safety assessment according to production regions of Platycodi Radix which is produced in Gyeongbuk.
Methods : Platycodin D, which is the major biologically active compound of Platycodi Radix was measured using HPLC. Physicochemical characteristics of Platycodi Radix collected from 10 regions of Gyeongbuk were analyzed nutritional compositions. And physical properties measured by texture profile analyzer. The analysis of residual pesticides investigated using GC-ECD.
Results : HPLC analysis showed that platycodin D content of Platycodi Radix associated with produced by Yeongju was the highest of 113.6 ㎍/㎖, otherwise, its content by Andong was the lowest of 20.3 ㎍/㎖. The highest calory and protein among general nutrition compositions is produced by Yeongju. Moreover, Platycodi Radix produced by Yeongcheon with the lowest hardness needed the lowest energy at gumminess. In addition, residual pesticides didn't detect all regions of Gyeongbuk.
Conclusions : Taken together, the primary component or texture of Platycodi Radix grown 10 regions of Gyeongbuk are many derivations. However, Platycodi Radix in all regions of Gyeongbuk didn't detect residual pesticides. Accordingly, the additional researchs about Platycodi Radix are asked. And then, it is necessary to standardize the manufacture process for smooth supply of effective Platycodi Radix.

8안동산 두충의 유효성분 및 물성 비교 분석

저자 : 김문정 ( Moon Jeong Kim ) , 김연수 ( Yeon-soo Kim ) , 황보민 ( Min Hwangbo ) , 지선영 ( Seon-young Jee )

발행기관 : 한약응용학회 간행물 : 한약응용학회지 19권 1호 발행 연도 : 2019 페이지 : pp. 99-106 (8 pages)

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Backgrounds : Eucommiae cortex is traditionally being used for therapeutic agent. It is commonly known as Du-choong in Korean. Previous reserch has shown that it exerts a various beneficial effects such as anti-oxidant, anti-inflammatory, anti-hypertention, and the other pharmachological efficacy. Although Du-choong has recently been shown to exert various effects, whether the primary component or texture of Du-choong associated with supplier are similar is currently unknown.
Objective : The aim of this study is to compare and evaluate ingredient and charicteristics according to supplier of Du-choong which is produced in Andong.
Methods : Pinoresinol-diglucoside, which is the bioactive compound of Eucommiae cortex is detected using HPLC. Physicochemical characteristics of Du-choong collected from the different supplier were analyzed nutritional compositions of Du-choong. And physical properties measured by texture profile analyzer.
Results : HPLC analysis showed that Pinoresinol-diglucoside content of Du-choong supplied by Boro was the highest of 103.4 ㎍/㎖, otherwise, its content by Daehoon herbal medicine dealer was the lowest of 10.9 ㎍/㎖. The highest protein and sodium contents among general nutrition compositions are Du-choong supplied by Jung woo Dang. Moreover, Du-choong supplied by Daehoon herbal medicine dealer with the highest hardness needed a high energy both gumminess and chewiness.
Conclusions : Taken together, the primary component or texture of Du-choong grown at Andong associated with supplier are many derivations. Accordingly, the additional researchs about Du-choong cultivated in different districts are asked. And then, it is necessary to standardize the manufacturing process for harmonious supply of effective Du-choong.

9택사의 항비만 효과 및 항산화 효과

저자 : 목정일 ( Jeong Il Mok ) , 김난이 ( Nan-ee Kim ) , 황보민 ( Min Hwangbo ) , 지선영 ( Seon-young Jee )

발행기관 : 한약응용학회 간행물 : 한약응용학회지 19권 1호 발행 연도 : 2019 페이지 : pp. 107-116 (10 pages)

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Objectives : The aim of this study is to investigate the inhibitory effect of pancreatic lipase and its anti-oxidant effect of Alisma orienta water extract (AOE).
Methods : Alisma orienta (30 g) was extracted 10 times with distilled water (300 ㎖) for 2h. The inhibitory activity on pancreatic lipase enzyme of AOE was evaluated in vitro and its anti-oxidant effects were studied based on 2.2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and 2,2ʹ-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay. In addition, total phenolic content was measured as gallic acid equivalents (GAE) by the reference and the flavonoid content was measured as naringin equivalent (NE) by the reference.
Results : In our current study, the obtained result showed that AOE inhibited pancreatic lipase activity with IC50 of below 1 ㎍/㎖. The IC50 of DPPH radical scavenging activity of AOE was 489.19 ± 1.02 ㎍/㎖ and the IC50 value of ascorbic acid as a positive control was 1.17 ± 0.04 ㎍/ ㎖. Moreover, the calculated IC50 value of AOE against the ABTS radical was 120.04 ± 1.67 ㎍/㎖ and the IC50 value of ascorbic acid as a positive control was 2.27 ± 0.19 ㎍/㎖. Total phenolic content was found to 6.29 ± 0.05 ㎎ GAE/g of AOE. The flavonoid content was 1.56 ± 0.02 ㎎ naringin equivalent (NE)/g of AOE.
Conclusions : Taken together, AOE may exert anti-obesity effect by directly inhibiting pancreatic lipase, which would limit the lipid absorption from the small intestine. Accordingly, AOE administration may attenuate the physiological lipid changes caused by obesity.

10유근피의 스코폴라민으로 유도된 Mice의 기억력 장애 개선

저자 : 김응규 ( Eung-gyu Kim ) , 정지욱 ( Ji-wook Jung ) , 노성수 ( Seong-soo Roh )

발행기관 : 한약응용학회 간행물 : 한약응용학회지 19권 1호 발행 연도 : 2019 페이지 : pp. 117-125 (9 pages)

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Objectives : The purpose of this study was to characterize the neuroprotective effects of the water extracts of Ulmus davidiana var japonica on the learning and memory impairments induced by scopolamine.
Methods : The cognition-enhancing effect of Ulmus davidiana was investigated using a passive avoidance test, the Morris water maze test and Y-maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 ㎎/㎏, i.p.).
Results : A single treatment of Ulmus davidiana (50, 100 and 200 ㎎/㎏) significantly reversed the scopolamine-induced cognitive impairments in mice on the passive avoidance test in a does dependant manner (100 and 200 ㎎/㎏) without affecting the electric-shock induced behavior score. Ulmus davidiana (200 ㎎/㎏) also improved escape latencies in training trials and increased swimming times in the target zone of the Morris water maze (P < 0.05). On the Y-maze test, Ulmus davidiana (100 and 200 ㎎/㎏) also significantly reversed scopolamine­induced cognitive impairments in mice (P < 0.05).
Conclusions : The water extracts of Ulmus davidiana dramatically possesses the anti-amnestic and cognitive-enhancing activities related to the memory processes, and these activities were parallel to treatment duration and dependent on the learning models.

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경희대학교 전남대학교 청주대학교 제주과학고등학교 대구한의대학교(구 경산대학교)
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