간행물

대한내과학회> The Korean Journal of Internal Medicine

The Korean Journal of Internal Medicine update

  • : 대한내과학회
  • : 의약학분야  >  내과학
  • : KCI등재
  • : SCI
  • : 연속간행물
  • : 격월
  • : 1226-3303
  • : 2005-6648
  • :

수록정보
수록범위 : 1권1호(1986)~35권3호(2020) |수록논문 수 : 2,325
The Korean Journal of Internal Medicine
35권3호(2020년 05월) 수록논문
최근 권호 논문
| | | |

KCI등재 SCI

1Current status of heart failure: global and Korea

저자 : Jin Joo Park , Dong-ju Choi

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 35권 3호 발행 연도 : 2020 페이지 : pp. 487-497 (11 pages)

다운로드

(기관인증 필요)

초록보기

Heart failure (HF) is a condition in which the heart is unable to pump enough blood to meet the body's needs for blood and oxygen. Thus, HF is a grave disease with high morbidity and mortality. Because the prevalence of and exposure to the risk factors for HF increase with age, the prevalence of HF has been increasing in an aging society, including Korea. The vast advancement of medical and device therapy has improved the outcomes of HF, but significant residual risk still exists, and the benefit is confined to patients with reduced ejection fraction. Finding effective treatment for HF with preserved ejection fraction and identification of groups who benefit from drug and device therapy remain challenging. In this review, we illustrate the epidemiology, temporal trends, and current status of medical and device therapy, including heart transplantation, as well as emerging treatments for HF in Korea and worldwide.

KCI등재 SCI

2Angiotensin receptor-neprilysin inhibitor for the treatment of heart failure: a review of recent evidence

저자 : Hong-mi Choi , Mi-seung Shin

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 35권 3호 발행 연도 : 2020 페이지 : pp. 498-513 (16 pages)

다운로드

(기관인증 필요)

초록보기

Heart failure (HF) is a growing health concern in aging societies worldwide. Sacubitril/valsartan is changing the real-world treatment in the whole spectrum of HF. The beginning was the PARADIGM-HF trial published in 2014, which demonstrated the beneficial effects of inhibiting natriuretic peptide breakdown in combination with hindering the renin-angiotensin system in HF patients with a reduced ejection fraction. Subsequent large-scale randomized trials have evaluated angiotensin receptor-neprilysin inhibitor in HF patients with acute decompensation or with preserved ejection fraction. The post hoc analyses are being conducted as well. This review summarizes the recent evidence of sacubitril/valsartan regarding patient-centered outcomes, based on randomized controlled trials and their associated studies.

KCI등재 SCI

3Heart failure with preserved ejection fraction: insights from recent clinical researches

저자 : Mi-na Kim , Seong-mi Park

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 35권 3호 발행 연도 : 2020 페이지 : pp. 514-534 (21 pages)

다운로드

(기관인증 필요)

초록보기

Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for nearly half of the cases of HF and its incidence might be increasing with the aging society. Patients with HFpEF present with significant symptoms, including exercise intolerance, impaired quality of life, and have a poor prognosis as well as frequent hospitalization and increased mortality compared with HF with reduced ejection fraction. The concept of HFpEF is still evolving and may be a virtual complex rather than a real systemic disorder. Thus, beyond solely targeting cardiac abnormalities management strategies need to be extended, such as left ventricular diastolic dysfunction. In this review, we examine new diagnostic algorithms, pathophysiology, current management status, and ongoing trials based on heterogeneous pathophysiology and etiology in HFpEF.

KCI등재 SCI

4Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs

저자 : Tae Young Park , Hyoung-chul Oh , Evan L. Fogel , Glen A. Lehman

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 35권 3호 발행 연도 : 2020 페이지 : pp. 535-543 (9 pages)

다운로드

(기관인증 필요)

초록보기

Acute pancreatitis is the most common and feared adverse event associated with performance of endoscopic retrograde cholangiopancreatography (ERCP). Unremitting effort has been made for over 40 years to minimize the frequency and severity of this complication. Recently, the use of rectal non-steroidal anti-inflammatory drugs (NSAIDs) have opened a new era for its prevention. This review focuses on the role of NSAIDs in pancreatitis, the pharmacokinetics of these agents, and summarizes the results of clinical trials with rectal NSAIDs alone and combination regimens in the prevention of post-ERCP pancreatitis.

KCI등재 SCI

5Is serum pepsinogen testing necessary in population-based screening for gastric cancer?

저자 : Yeon-ji Kim , Woo Chul Chung

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 35권 3호 발행 연도 : 2020 페이지 : pp. 544-546 (3 pages)

다운로드

(기관인증 필요)

키워드 보기
초록보기

KCI등재 SCI

6We can do much better than what we did

저자 : Sang-hak Lee

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 35권 3호 발행 연도 : 2020 페이지 : pp. 547-549 (3 pages)

다운로드

(기관인증 필요)

키워드 보기
초록보기

KCI등재 SCI

7Clinical correlation between serum pepsinogen level and gastric atrophy in gastric neoplasm

저자 : Jae Hwang Cha , Jin Seok Jang

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 35권 3호 발행 연도 : 2020 페이지 : pp. 550-558 (9 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aims: The relationship between the serum pepsinogen (sPG) level and changes in gastric mucosa has been well studied. Here, we evaluated the usefulness of sPG (I, II, I/II ratio) and intragastric pH as a biomarker of severe gastric atrophy in gastric neoplastic lesions.
Methods: A total of 186 consecutive Korean patients with gastric neoplastic lesions underwent endoscopic submucosal dissection (ESD) in this study. The serologic atrophy group had sPG I level ≤ 70 ng/mL and an sPG I/II ratio ≤ 3.0. Before ESD, overnight fasting venous blood and gastric juice samples were collected to measure the sPG level and intragastric pH. The degree of gastric atrophy was estimated by endoscopy, and the rapid urease test was performed to investigate Helicobacter pylori infection.
Results: Patients who met the criteria of serologic atrophy showed more severe endoscopic atrophic changes (61% vs. 18%, p = 0.000). Older patients and those with more atrophic changes at the gastric upper body demonstrated both a lower sPG I level and a lower PG I/II ratio and more severe endoscopic atrophy. The sPG I/II ratio was the lowest in low grade dysplasia than in high grade dysplasia and early gastric cancer (EGC) (p = 0.015). In addition, patients who tested negative for serologic atrophy and H. pylori showed the lowest intragastric pH (p = 0.000).
Conclusions: A low sPG I level and a low I/II ratio were correlated with the severity of gastric atrophy in gastric neoplastic lesions, thus indicating it to be a sensitive biomarker of gastric precancerous lesions or EGC.

KCI등재 SCI

8Full-dose sofosbuvir plus low-dose ribavirin for hepatitis C virus genotype 2-infected patients on hemodialysis

저자 : Hee Yeon Seo , Myeong-sook Seo , Sun-young Yoon , Jong Wook Choi , Soon Young Ko

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 35권 3호 발행 연도 : 2020 페이지 : pp. 559-565 (7 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aims: New direct-acting antivirals have shown surprising success in the treatment of hepatitis C, not only in the general population, but also in difficult-to-treat cohorts. However, there is still limited data regarding direct-acting antivirals, including sofosbuvir (SOF), in the context of hemodialysis. The aim of this study was to investigate the safety and outcome of administering full-dose SOF (400 mg/day) plus low-dose ribavirin (RBV, 100 to 200 mg/day) in hemodialysis patients with hepatitis C virus (HCV) genotype 2 (GT2) infection.
Methods: Patients with chronic HCV GT2 infection and end-stage renal disease on maintenance hemodialysis treated with full-dose SOF plus low-dose RBV were retrospectively identified from a database of patients with HCV GT2 who were treated in Konkuk University Chungju Hospital between February 2017 and February 2018. Medical records were reviewed for demographics, medical history, laboratory data, and radiologic and electrocardiographic findings.
Results: All nine patients completed a full course of 12 weeks of treatment with a full-dose SOF plus low-dose RBV regimen. Two had compensated cirrhosis. Seven patients were treatment-naive, and two had a relapse following previous interferon-based therapy. All patients had a sustained viral response at 12 weeks post-treatment. There was no discontinuation of treatment because of side effects.
Conclusions: In hemodialysis patients with HCV GT2 infection, the full-dose SOF plus low-dose RBV regimen appears to be safe and well tolerated, and yields high rates of sustained virologic response.

KCI등재 SCI

9Prognostic impact of hepatitis B or C on intrahepatic cholangiocarcinoma

저자 : Jung Woong Seo , Byung Soo Kwan , Young Koog Cheon , Tae Yoon Lee , Chan Sup Shim , So Young Kwon , Won Hyeok Choe , Byung Chul Yoo , Jeong Min Yoon , Jung Hoon Lee

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 35권 3호 발행 연도 : 2020 페이지 : pp. 566-573 (8 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aims: Intrahepatic cholangiocarcinoma (ICC) is the second-most common primary liver malignancy, arising from the peripheral intrahepatic bile duct epithelium. Hepatitis B virus (HBV) or hepatitis C virus (HCV) may be involved in the development of ICC. We explored the prognostic value of hepatitis virus infection, as well as other prognostic factors affecting survival in patients with ICC.
Methods: A retrospective chart review was performed for patients diagnosed with ICC between August 2005 and December 2018 at Konkuk University Medical Center. We identified a total of 131 patients with ICC. Overall survival rates of patients with and without hepatitis were determined. Univariate and multivariate analyses were used to estimate factors influencing survival outcomes.
Results: A total of 17.6% (23/131) of patients were positive for HBV or HCV. Hepatitis B positive ICC patients were significantly younger with higher albumin and higher α-fetoprotein than those without hepatitis viral infections. The median survival of hepatitis-positive and hepatitis-negative groups was 280 and 213 days, respectively. Survival rates were not significantly different between the two groups (p = 0.279). Multivariate analyses indicated that lower serum carbohydrate antigen 19-9 (CA 19-9) (p < 0.001), lower T stage (p = 0.042), the absence of lymph-node metastasis (p = 0.043), and receiving curative surgery (p = 0.033) were independent predictors of better outcomes.
Conclusions: While hepatitis influenced a number of clinical features in ICC patients, it did not affect survival rate. Prognostic factors influencing survival outcomes with ICC were CA 19-9 level, T stage, the presence of lymph node metastasis, and curative surgery.

KCI등재 SCI

10Effects of probiotics or broccoli supplementation on Helicobacter pylori eradication with standard clarithromycin-based triple therapy

저자 : Young Woon Chang , Yoo Min Park , Chi Hyuk Oh , Shin Ju Oh , Jun-hyung Cho , Jung-wook Kim , Jae-young Jang

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 35권 3호 발행 연도 : 2020 페이지 : pp. 574-581 (8 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aims: The eradication failure rate of standard triple therapy (proton pump inhibitor, clarithromycin, and amoxicillin) for Helicobacter pylori infection has increased owing to antibiotic resistance in Korea. We assessed whether Saccharomyces boulardii probiotic or broccoli sprout extract sulforaphane supplementation could increase the H. pylori eradication rate and/or reduce antibiotic-associated adverse events.
Methods: A total of 217 patients with H. pylori-positive chronic gastritis or peptic ulcer disease were recruited. Clarithromycin resistance was assessed in all patients by testing for A2142G and A2143G point mutations in H. pylori 23S rRNA using a dual-priming polymerase chain reaction (PCR) oligonucleotide. Thirty-four patients (17.3%) were clarithromycin-resistant and were excluded from the study. Finally, 183 patients with infections not resistant to clarithromycin were randomly assigned to triple therapy only (group A, n = 61), triple therapy plus probiotics (group B, n = 61), or triple therapy plus sulforaphane (group C, n = 61) groups. CYP2C19 polymorphisms were examined at position G681A of exon 5 and G636A of exon 4 by PCR with restriction fragment length polymorphism (PCR-RFLP) analysis. H. pylori eradication was assessed by 13C-urea breath test 4 weeks after treatment completion.
Results: The eradication rates were similar among the groups both in the intention- to-treat (A = 85.2%, B = 89.6%, and C = 81.6%) and per-protocol (A = 89.2%, B = 86.8%, and C = 96.3%) analyses. The frequencies of overall adverse events in the groups also did not differ (A vs. B: p = 0.574; A vs. C: p = 1.000).
Conclusions: Probiotic or sulforaphane with triple therapy for H. pylori infection neither increased the eradication rate nor reduced the occurrence of adverse events.

123
권호별 보기
가장 많이 인용된 논문

(자료제공: 네이버학술정보)

가장 많이 인용된 논문
| | | |
1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

다운로드

2미국의 비트코인 규제

(2006)홍길동심리학41회 피인용

다운로드

가장 많이 참고한 논문

(자료제공: 네이버학술정보)

가장 많이 참고한 논문

다운로드

2미국의 비트코인 규제

(2006)홍길동41회 피인용

다운로드

해당 간행물 관심 구독기관

마산대학교 경희대학교 Monash University 고려대학교 혜전대학교
 8
 8
 5
 4
 4
  • 1 마산대학교 (8건)
  • 2 경희대학교 (8건)
  • 3 Monash University (5건)
  • 4 고려대학교 (4건)
  • 5 혜전대학교 (4건)
  • 6 동국대학교 (4건)
  • 7 경북대학교 (3건)
  • 8 연세대학교 (2건)
  • 9 우석대학교 (2건)
  • 10 이화여자대학교 (1건)

내가 찾은 최근 검색어

최근 열람 자료

맞춤 논문

보관함

내 보관함
공유한 보관함

1:1문의

닫기