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대한피부과학회> Annals of Dermatology

Annals of Dermatology update

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  • : 의약학분야  >  피부과학
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수록범위 : 1권1호(1989)~32권6호(2020) |수록논문 수 : 2,897
Annals of Dermatology
32권6호(2020년 12월) 수록논문
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KCI등재 SCI SCOPUS

1The Role of MicroRNAs in Vitiligo: Regulators and Therapeutic Targets

저자 : Lili Li

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 32권 6호 발행 연도 : 2020 페이지 : pp. 441-451 (11 pages)

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Vitiligo is an acquired skin disorder clinically characterized by the progressive appearance of white maculae due to a loss of functioning epidermal melanocytes. Studies have shown that microRNAs (miRNAs) modulate cellular differentiation, proliferation and apoptosis, including immune cell and melanocyte development and functions. The role of miRNAs in the pathogenesis of several immune-related diseases has been explored. Novel approaches to target miRNAs have recently emerged allowing modulation of miRNAs levels in diverse pathological processes, thus making them promising targets for molecular-based diagnostics and therapy. Here, we report the present status of research on miRNAs expression and functional alterations in vitiligo, in order to more fully understand the role of these molecules in vitiligo pathology. (Ann Dermatol 32(6) 441∼451, 2020)

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2The Temperament Risk Factor, Disease Severity, and Quality of Life in Patients with Psoriasis

저자 : Konrad Janowski , Stanisława Steuden

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 32권 6호 발행 연도 : 2020 페이지 : pp. 452-459 (8 pages)

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Background: Psoriasis exerts a profound negative impact on health-related quality of life (QoL). Although the severity of psoriasis is one potential variable that contributes to decreased QoL, previous studies have shown only weak or no association between measures of psoriasis severity and QoL. We hypothesized that this relationship is moderated by temperament factors. Objective: We aimed to verify whether the relationship between disease severity and QoL is moderated by a constellation of temperament traits (i.e., temperament risk factors) and whether this moderation takes place via cognitive- appraisal and coping processes. Methods: One hundred fifty patients with psoriasis vulgaris participated in the study. Psoriasis severity was assessed by a standardized measure, the Psoriasis Area and Severity Index (PASI), and the patients also completed a battery of psychological questionnaires assessing QoL, temperament, disease-related cognitive appraisals, and coping strategies. Results: A specific constellation of temperament traits was found to moderate the strength of the association between the PASI and QoL. This constellation of temperament traits was associated with certain disease-related cognitive appraisals (i.e., threat, obstacle/ loss, harm, profit, value) and emotion-focused coping strategies (i.e., self-blame, avoidance, resignation, seeking social support, and seeking information). Conclusion: The constellation of temperament traits is a crucial individual variable that strongly moderates the negative impact of psoriasis severity on QoL, potentially through the activation of nonadaptive cognitive appraisals and coping strategies in susceptible individuals. (Ann Dermatol 32(6) 452∼459, 2020)

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3Clinical and Dermoscopic Features of Fungal Melanonychia: Differentiating from Subungual Melanoma

저자 : Hak-jun Kim , Tae-wook Kim , Sung-min Park , Hyun-joo Lee , Gun-wook Kim , Hoon-soo Kim , Byung-soo Kim , Moon-bum Kim , Hyun-chang Ko

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 32권 6호 발행 연도 : 2020 페이지 : pp. 460-465 (6 pages)

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Background: Fungal melanonychia (FM) is a rare nail disorder that presents as dark pigmentation in the nail plate because of fungal nail infection. The diagnosis of FM is occasionally confusing because its appearance is similar to melanonychia due to other causes including malignant melanoma. Dermoscopy could help increase the accuracy of diagnosing the cause of pigmented nail lesions. However, dermoscopic features of FM are not well elucidated. Objective: This study aimed to investigate clinical and dermoscopic characteristics of FM. Methods: The clinical features and dermoscopic findings of 20 patients diagnosed with FM and 14 patients diagnosed with subungual melanoma the Department of Dermatology of Pusan National University Hospitals (Busan and Yangsan) were retrospectively reviewed. Results: FM mainly occurred as a solitary form in the toenail. Patients in the FM group were older than those in the subungual melanoma group. The most distinguishable general dermoscopic features in FM were a distal diffuse pattern, distal linear pattern, and light brown to yellowish color. FM-associated specific dermoscopic patterns such as the reverse triangular pattern, subungual hyperkeratosis, scale on the nail surface, and white or yellowish streaks were dominantly observed in the FM group compared to the subungual melanoma group. Conclusion: FM-associated dermoscopic patterns and distal diffuse and linear patterns could be helpful diagnostic clues for differential diagnosis of FM from subungual melanoma. (Ann Dermatol 32(6) 460∼465, 2020)

KCI등재 SCI SCOPUS

4A Randomized, Placebo-Controlled Trial of Gamma Linolenic Acid as an Add-on Therapy to Minocycline for the Treatment of Rosacea

저자 : Ji Hyun Kim , Yong Woo Oh , Dong Hee Kim , Byeong Hak Seo , Ho Seok Suh , Yu Sung Choi

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 32권 6호 발행 연도 : 2020 페이지 : pp. 466-472 (7 pages)

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Background: A recent study suggested a possible role of skin barrier dysfunction in the pathogenesis of rosacea, which leads to irritation symptoms. Gamma linolenic acid (GLA) is an essential omega-6 fatty acid that is known to restore defective epidermal skin barrier. GLA supplementation has not previously been performed in rosacea patients. Objective: To investigate the efficacy and safety of adding GLA to minocycline compared to minocycline alone in rosacea patients. Methods: This prospective, double-blind, randomized, placebo- controlled trial enrolled 31 rosacea patients. They were randomly assigned to receive 320 mg/day of GLA (Evoprim) (n=16) or placebo (n=15) in addition to 100 mg/day of minocycline for 8 weeks. Investigator's global assessment (IGA) and patient's global assessment (PGA) were used to assess clinical severity at weeks 0, 4, 8, and 12. Biophysical parameters including melanin index, erythema index, transepidermal water loss (TEWL), lipid concentration, and stratum corneum hydration were measured. Results: In the GLA group, a higher proportion of patients achieved treatment success (IGA≤1) at week 8 (68.75% vs. 33.33%) and patient satisfaction (PGA≥3) at weeks 8 (75.0% vs. 40.0%) and 12 (81.3% vs. 46.6%). Both groups, throughout 12 weeks of treatment, revealed a trend toward improvement in erythema index, melanin index, TEWL, and stratum corneum hydration. Particularly, there was a significant difference in TEWL and stratum corneum hydration over time between the two groups (p=0.033, p=0.003, respectively). No serious adverse event was observed in both groups. Conclusion: GLA is beneficial as an additional therapeutic option for rosacea patients treated with minocycline. (Ann Dermatol 32(6) 466∼472, 2020)

KCI등재 SCI SCOPUS

5pH-Dependent Expression, Stability, and Activity of Malassezia restricta MrLip5 Lipase

저자 : Minji Park , Ji Su Lee , Won Hee Jung , Yang Won Lee

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 32권 6호 발행 연도 : 2020 페이지 : pp. 473-480 (8 pages)

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Background: The lipophilic yeasts Malassezia spp. are normally resident on the surface of the human body, and often associated with various skin diseases. Of the 18 known Malassezia spp., Malassezia restricta is the most predominantly identified Malassezia sp. found on the human skin. Malassezia possesses a large number of genes encoding lipases to degrade human sebum triglycerides into fatty acids, which are required not only for their growth, but also trigger skin diseases. Previously, we have shown that MrLIP5 (MRET_0930), one of the 12 lipase genes in the genome of M. restricta, and is the most frequently expressed lipase gene in the scalp of patients with dandruff. Objective: In this study, we aimed to analyze the activity, stability, and expression of MrLip5, with particular focus on pH. Methods: We heterologously expressed MrLip5 in Escherichia coli, and purified and analyzed its activity and expression under different pH conditions. Results: We found that MrLip5 was most active and stable and highly expressed under alkaline conditions, which is similar to that of the diseased skin surface. Conclusion: Our results suggest that the activity and expression of MrLip5 are pH-dependent, and that this lipase may play an essential role at the M. restricta-host interface during disease progression. (Ann Dermatol 32(6) 473∼480, 2020)

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6Possible Role of Lysine Demethylase 2A in the Pathophysiology of Psoriasis

저자 : Dong Ha Kim , Mi-ra Choi , Jae Kyung Lee , Dong-kyun Hong , Kyung Eun Jung , Chong Won Choi , Young Lee , Chang-deok Kim , Young-joon Seo , Jeung-hoon Lee

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 32권 6호 발행 연도 : 2020 페이지 : pp. 481-486 (6 pages)

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Background: Psoriasis is a common chronic inflammatory skin disease. The development of psoriasis is dependent on many intercellular events such as innate immunity and T cell-mediated inflammation. Furthermore, genetic factors are strongly implicated in the pathophysiology of psoriasis. Although a variety of susceptible genes are identified, it is likely that many important genes remain undisclosed. Objective: The aim of this study is to investigate the possible role of lysine demethylase 2A (KDM2A) in the pathophysiology of psoriasis. Methods: We examined the expression of KDM2A using a well established imiquimod-induced psoriasiform dermatitis model. Results: Immunohistochemistry analysis showed that expression of KDM2A was increased in imiquimod-induced psoriasiform dermatitis. Consistent with this result, KDM2A level was markedly increased in the epidermis of psoriatic patient. When keratinocytes were stimulated with TLR3 agonist poly(I:C), KDM2A was increased at both the mRNA and protein levels. Poly(I:C) increased the expression of psoriasis-related cytokines including tumor necrosis factor-α, interleukin-8, and CCL20, and KDM2A inhibitor daminozide enhanced the poly(I:C)-induced cytokine expression. Finally, topical co-application of imiquimod and daminozide exacerbated the imiquimod-induced psoriasiform dermatitis. Conclusion: Together, these results suggest that KDM2A is increased to negatively regulate the inflammatory reaction of epidermal keratinocytes in psoriasis. (Ann Dermatol 32(6) 481∼486, 2020)

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7Open versus Closed Surgery for Axillary Osmidrosis: A Meta-Analysis of Articles Published in Four Languages

저자 : Misako Nomura , Daichi Morioka , Yasutaka Kojima , Ryutaro Tanaka , Koichi Kadomatsu

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 32권 6호 발행 연도 : 2020 페이지 : pp. 487-495 (9 pages)

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Background: Individuals with axillary osmidrosis suffer detrimental effects to their psychosocial functioning. In Asian nations, major operations for axillary osmidrosis include subdermal excision (open surgery) and suction-curettage (closed surgery). Objective: The aim of this meta-analysis was to determine which of these two procedures is most favorable in terms of safety and efficacy. Methods: According to the Preferred Reporting Items for Systematic Reviews and Metaanalyses (PRISMA) guideline, we searched electronic databases for articles published in English, Japanese, Korean, and Chinese languages. Fixed-effects model meta-analyses of odds ratios (OR) and 95% confidence intervals (CI) were conducted, and the I2 was used to assess heterogeneity. Complication rates, recurrence/ineffectiveness rates, and patient satisfaction data were extracted and compared between open and closed surgeries. Results: Our search yielded 8 articles that include 1,179 patients; 560 underwent open surgery, and 619 underwent closed surgery. Our meta-analysis revealed that suction-curettage had a significantly lower risk of acute adverse events than open excision (OR, 0.15; 95% CI, 0.07∼0.32), whereas open excision was significantly superior to suction-curettage for recurrence/ineffectiveness rate (OR, 2.90; 95% CI, 1.37∼6.15). Patient satisfaction was equally high with both treatments (OR, 1.58; 95% CI, 0.69∼ 3.60). Conclusion: Since surgical treatments for axillary osmidrosis have been performed mostly in East Asian nations, it was meaningful to review articles published in four languages. This meta-analysis revealed that closed surgery was safer but less effective than open surgery. However, both patient groups expressed high satisfaction with the outcomes. Our results may be helpful for deciding surgical treatment options. (Ann Dermatol 32(6) 487∼495, 2020)

KCI등재 SCI SCOPUS

8Effects of Particulate Matter in a Mouse Model of Oxazolone-Induced Atopic Dermatitis

저자 : Yoo Jung Bae , Kui Young Park , Hye Sung Han , Young Shin Kim , Ji Yeon Hong , Tae Young Han , Seong Jun Seo

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 32권 6호 발행 연도 : 2020 페이지 : pp. 496-507 (12 pages)

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Background: Recent epidemiological studies have demonstrated that air pollution is associated with the inflammatory response and may aggravate inflammatory skin diseases such as atopic dermatitis (AD). However, it is unclear whether particulate matter (PM) aggravates AD symptoms. Objective: The aim of this study was to investigate whether PM exposure affects the skin barrier dysfunction and aggravates AD symptoms using human keratinocytes (HaCaT) cells and a mouse model of oxazolone-induced AD-like skin. Methods: Standard reference material (SRM) 1649b, which mainly comprises polycyclic aromatic hydrocarbons, was used as the reference PM. HaCaT cells and mouse model of oxazolone-induced AD-like skin were treated with PM. The mRNA or protein expression levels of stratum corneum (SC) and tight junction (TJ) proteins, inflammatory cytokines, as well as clinical and histological changes of the AD-like skin of mouse model were evaluated. The expression of genes and proteins was analyzed by real-time polymerase chain reaction and Western blotting. Levels of inflammatory cytokines were measured by enzyme-linked immunosorbent assay. Results: The results revealed that PM downregulates the expression levels of several SC and TJ-related proteins in the mouse model with AD-like skin. Clinically, epidermal and dermal thickness was significantly increased and dermal inflammation was prominent in PM treated AD-like skin. Conclusion: In conclusion, we found that PM aggravates skin barrier dysfunction, clinically augmenting epidermal and dermal thickening with dermal inflammation in AD-like skin. These results suggest that PM may trigger the exacerbation of AD symptoms via skin barrier dysfunction-related mechanisms. (Ann Dermatol 32(6) 496∼507, 2020)

KCI등재 SCI SCOPUS

9A Case of Livedoid Vasculopathy Successfully Treated with Sulodexide

저자 : Chang Hwa Song , Dong Seok Shin , Ju Wang Jang , Tae Lim Kim , Young Gyun Kim , Joung Soo Kim , Hyun-min Seo

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 32권 6호 발행 연도 : 2020 페이지 : pp. 508-511 (4 pages)

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We report a 29-year-old female with a one-month history of non-healing multiple erythematous to violaceous plaques with crusts over both legs and feet. Tender, scarring ulcers with surrounding erythema were present. The clinical manifestation, together with histopathologic findings of fibrinoid plugs within vascular lumens and walls, as well as red blood cell extravasation, led to diagnosis of livedoid vasculopathy. The patient experienced recurrent painful violaceous plaques with ulcerations during the two years of treatment with oral pentoxifylline 400 mg three times daily. The cutaneous lesions and symptoms dramatically improved after the treatment regimen changed to oral sulodexide (250 lipasemic units) three times daily. Sulodexide, a highly purified mixture of glycosaminoglycans including dermatan sulfate and lowmolecular weight heparin, could be an effective therapy for recalcitrant livedoid vasculopathy. Herein, we report a case of livedoid vasculopathy treated with sulodexide, which has not previously been reported. (Ann Dermatol 32(6) 508∼511, 2020)

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10Two Cases of Multiple Epidermolytic Acanthomas Mimicking Verruca Vulgaris

저자 : Hyun Jeong Byun , Donghwi Jang , Jongeun Lee , Se Jin Oh , Ji-hye Park , Dong-youn Lee

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 32권 6호 발행 연도 : 2020 페이지 : pp. 512-515 (4 pages)

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Epidermolytic acanthoma (EA) is a rare benign tumor, which usually appears as a solitary small papule. However, there are a few case reports of multiple EA, most of which occurs on the genital area. Cases of multiple EA may mimic verruca vulgaris, condyloma accuminatum, seborrheic keratosis, and bowenoid papulosis, and therefore, can be easily misdiagnosed. A 78-year-old male presented with a 2-week history of discrete, small skin-colored papules around the anus. The other case involved a 47-year-old male with a 5-year history of skin-colored papules on the scrotum. Skin biopsy of both cases revealed a well-demarcated papular lesion characterized by compact hyperkeratosis, perinuclear vacuolization, and reticular degeneration in the granular and upper spinous layer with coarse basophilic keratohyalin granules. Epidermal invagination was consistent with a cup-shaped type of EA. Both cases tested negative for human papillomavirus. We report typical cases of multiple EA, which should be considered as the differential diagnosis of small skin-colored papules in the anogenital area, to prevent the misdiagnosis. (Ann Dermatol 32(6) 512∼515, 2020)

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