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대한간학회> Clinical and Molecular Hepatology(대한간학회지)

Clinical and Molecular Hepatology(대한간학회지) update

Clinical and Molecular Hepatology (CMH)

  • : 대한간학회
  • : 의약학분야  >  내과학
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  • : 2287-2728
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  • : 대한간학회지()→Korean Journal of Hepatology(2004~)→대한간학회지(2012~)

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수록범위 : 1권1호(1995)~25권2호(2019) |수록논문 수 : 4,562
Clinical and Molecular Hepatology(대한간학회지)
25권2호(2019년 06월) 수록논문
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KCI등재 SCOPUS

1KASL clinical practice guidelines for management of chronic hepatitis B

저자 : 대한간학회

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 25권 2호 발행 연도 : 2019 페이지 : pp. 93-159 (67 pages)

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KCI등재 SCOPUS

2Advances in ultrasound diagnosis in chronic liver diseases

저자 : Hitoshi Maruyama , Naoya Kato

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 25권 2호 발행 연도 : 2019 페이지 : pp. 160-167 (8 pages)

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Chronic liver disease is a major disorder worldwide. A better understanding of anatomy, blood flow, and pathophysiology may be a key issue for their proper management. Ultrasound (US) is a simple and non-invasive diagnostic tool in the abdominal field. Doppler mode offers real-time hemodynamic evaluation, and the contrast-enhanced US is one of the most frequently used modalities for the detailed assessment. Further development in digital technology enables three-dimensional (3D) visualization of target images with high resolution. This article reviews the wide ranges of application in the abdominal US and describes the recent progress in the diagnosis of chronic liver diseases. (Clin Mol Hepatol 2019;25:160-167)

KCI등재 SCOPUS

3Direct-acting antivirals response in hepatocellular carcinoma: Does the presence of hepatocellular carcinoma matter?

저자 : Chung-feng Huang , Ming-lung Yu

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 25권 2호 발행 연도 : 2019 페이지 : pp. 168-171 (4 pages)

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During the clinical trial development of directly acting antivirals (DAAs), evidence regarding the treatment efficacy in chronic hepatitis C patients with hepatocellular carcinoma (HCC) was scarce because these patients have always been excluded. Apart from the clinical trials, more HCC patients are currently being treated in daily practice, given that these treatments are highly effective and involve well-tolerated regimens. Large scale, real-world studies have demonstrated potentially suboptimal antiviral treatment efficacy in HCC patients who received DAAs. It is postulated that the impairment of the bioavailability of DAAs may account for the inferior treatment response. However, the results could not be generalized across all studies. The differing results were attributed to diverse patient characteristics, suboptimal regimens or imprecise definitions of active cancer statuses at the time of treatment initiation. Additional large-scale studies that utilize the treatment of choice in clearly defined HCC patients with different disease severities are warranted to clarify the issue. (Clin Mol Hepatol 2019;25:168-171)

KCI등재 SCOPUS

4Unmet need in chronic hepatitis B management

저자 : Lilian Yan Liang , Grace Lai-hung Wong

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 25권 2호 발행 연도 : 2019 페이지 : pp. 172-180 (9 pages)

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Despite all these exciting developments, there remain some unmet needs in the management for patients with chronic hepatitis B (CHB). As majority of CHB patients are going to use oral nucleos(t)ide analogues (NAs) for decades, Safety profile of NAs is of no doubt an important issue. The newest nucleotide analogue tenofovir alafenamide is potent in terms of viral suppression, together with favourable renal and bone safety profile. Biochemical response as reflected by alanine aminotransferase (ALT) normalization is recently found to be prognostically important. Patients who achieved ALT normalization have reduced the risk of hepatic events by 49%. Functional cure as reflected by hepatitis B surface antigen seroclearance not only implies patients may stop NA treatment, it also confers to a reduced risk of hepatocellular carcinoma and other hepatic events. Hence functional cure should be the ultimate treatment goal in CHB patients. Preemptive antiviral treatment may reduce mother-to-child transmission of hepatitis B virus, especially if birth dose of vaccination cannot be given in the first two hours after delivery. Lastly, despite the currently first-line NAs have high-genetic barrier to drug resistance mutations, there are still are many patients who were previously treated with low barrier of resistance including lamivudine, telbivudine or adefovir dipivoxil which could lead to antiviral resistance and affecting the choice of NAs. (Clin Mol Hepatol 2019;25:172-180)

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6Endoscopic treatment or balloon-occluded retrograde transvenous obliteration is safe for patients with esophageal/gastric varices in Child-Pugh class C end-stage liver cirrhosis

저자 : Keiji Yokoyama , Ryo Yamauchi , Kumiko Shibata , Hiromi Fukuda , Hideo Kunimoto , Kazuhide Takata , Takashi Tanaka , Shinjiro Inomata , Daisuke Morihara , Yasuaki Takeyama , Satoshi Shakado , Shotaro Sakisaka

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 25권 2호 발행 연도 : 2019 페이지 : pp. 183-189 (7 pages)

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Background/Aims: There is a controversy about the availability of invasive treatment for esophageal/gastric varices in patients with Child-Pugh class C (CP-C) end-stage liver cirrhosis (LC). We have evaluated the validity of invasive treatment with CP-C end-stage LC patients.
Methods: The study enrolled 51 patients with CP-C end-stage LC who had undergone invasive treatment. The treatment modalities included endoscopic variceal ligation in 22 patients, endoscopic injection sclerotherapy in 17 patients, and balloon-occluded retrograde transvenous obliteration (BRTO) in 12 patients. We have investigated the overall survival (OS) rates and risk factors that contributed to death within one year after treatment.
Results: The OS rate in all patients at one, three, and five years was 72.6%, 30.2%, and 15.1%, respectively. The OS rate in patients who received endoscopic treatment and the BRTO group at one, three, and five years was 67.6%, 28.2% and 14.1% and 90.0%, 36.0% and 18.0%, respectively. The average of Child-Pugh scores (CPS) from before treatment to one month after variceal treatment significantly improved from 10.53 to 10.02 (P=0.003). Three significant factors that contributed to death within one year after treatment included the presence of bleeding varices, high CPS (≥11), and high serum total bilirubin levels (≥4.0 mg/dL).
Conclusions: The study demonstrated that patients with a CPS of up to 10 and less than 4.0 mg/dL of serum total bilirubin levels may not have a negative impact on prognosis after invasive treatment for esophageal/gastric varices despite their CP-C end-stage LC. (Clin Mol Hepatol 2019;25:183-189)

KCI등재 SCOPUS

7Evaluation of bioenergetic and mitochondrial function in liver transplantation

저자 : Rui Miguel Martins , Joao Soeiro Teodoro , Emanuel Furtado , Anabela Pinto Rolo , Carlos Marques Palmeira , Jose Guilherme Tralhao

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 25권 2호 발행 연도 : 2019 페이지 : pp. 190-198 (9 pages)

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Background/Aims: We measured changes in mitochondrial function and bioenergetics that occur during ischemia/reperfusion in fresh liver samples of patients undergoing liver transplantation. These variations correlated with markers of liver function and clinical outcome. Ischemia/reperfusion injury related to liver transplantation affects mitochondrial function and bioenergetics. Experimental studies were conducted to identify the role of bioenergetics and mitochondrial dysfunction. To the best of our knowledge, no investigation of these two factors' impacts on liver transplantation has been performed.
Methods: This was a prospective study of 28 patients who underwent liver transplantation. We measured parameters of mitochondrial function and bioenergetics in biopsies performed during the procedure.
Results: We observed a statistically significant reduction in mitochondrial membrane potential, an increase in lag phase, and decreases in mitochondrial respiration and adenosine triphosphate content (P<0.010). Higher postoperative aminotransferase peaks correlated with worse mitochondrial function; mitochondrial respiration correlated with arterial lactate (P<0.010).
Conclusions: There is a relationship between mitochondrial function and ischemia/reperfusion injury. The future use of these clinical markers as prognostic factors may allow early identification of post-transplant liver failure and may indicate the need to perform a new transplant. (Clin Mol Hepatol 2019;25:190-198)

KCI등재 SCOPUS

8Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial

저자 : Manoj Kumar Sharma , Sumeet Kainth , Sachin Kumar , Ankit Bhardwaj , Hemant Kumar Agarwal , Rakhi Maiwall , Kapil Dev Jamwal , Saggere Muralikrishna Shasthry , Ankur Jindal , Ashok Choudhary , Lovkesh Anand , R

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 25권 2호 발행 연도 : 2019 페이지 : pp. 199-209 (11 pages)

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Background/Aims: The aim of this study was to study the efficacy and safety of zolpidem for sleep disturbances in patients with cirrhosis.
Methods: Fifty-two Child-Turcotte-Pugh (CTP) class A or B cirrhotics with Pittsburgh Sleep Quality Index >5 were randomized to either zolpidem 5 mg daily (n=26) or placebo (n=26) for 4 weeks.
Results: The therapy of 4 weeks was completed by 23 patients receiving zolpidem (3 stopped treatment due to excessive daytime drowsiness) and 24 receiving placebo (2 refused to continue the study). In the zolpidem group, after 4 weeks of therapy, there was significant increase in total sleep time (TST) and sleep efficiency compared to baseline and improvement in polysomnographic parameters of sleep initiation and maintenance (i.e., decrease in sleep latency time, decrease in wake time, and decreases in number of arousals and periodic limbs movements per hour of sleep), without any significant change in sleep architecture.
Conclusions: Four weeks of 5 mg daily zolpidem in CTP class A or B cirrhosis patients with insomnia led to significant increases in TST and sleep efficiency and improvement in polysomnographic parameters of sleep initiation and maintenance without any significant change in sleep architecture. (Clin Mol Hepatol 2019;25:199-209)

KCI등재 SCOPUS

9Portal pressure gradient and serum albumin: A simple combined parameter associated with the appearance of ascites in decompensated cirrhosis treated with transjugular intrahepatic portosystemic shunt

저자 : Dongmei Zhao , Guobing Zhang , Mingquan Wang , Chaoxue Zhang , Jiabin Li

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 25권 2호 발행 연도 : 2019 페이지 : pp. 210-217 (8 pages)

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Background/Aims: In recent years, greater assessment accuracy after transjugular intrahepatic portosystemic shunt (TIPS) to ascertain prognosis has become important in decompensated cirrhosis due to portal hypertension. The aim of this study was to assess the ratio of the portal pressure gradient (PPG) pre-TIPS (pre-PPG) to albumin (PPA), which influence ascites formation in cirrhotic patients in the 6-months after TIPS placement, and is a metric introduced in our study.
Methods: This was a retrospective cohort study of 58 patients with decompensated cirrhosis admitted to an academic hospital for the purpose of TIPS placement. We collected the following data: demographics, laboratory measures, and PPG during the TIPS procedure. Then we analyzed the association between the above data and ascites formation post- TIPS in cirrhosis patients.
Results: Twenty-two patients with ascites and 28 without ascites were evaluated. Univariate and binary logistic regression analysis were adjusted for the following variables: to determine prognosis; Child-Pugh scores, lymphocyte count, platelet count, hemoglobin level, albumin level and pre-PPG or PPA. The outcome showed that PPA was better than pre-PPG and albumin for predicting ascites according to area under receiver operating characteristic curves and a statistical model that also showed PPA's influence 6-months post-TIPS.
Conclusions: The combined measurement of pre-PPG and albumin, defined as PPA, may provide a better way to predict post-TIPS ascites in decompensated cirrhosis, which underlines the need for a large clinical trial in the future. (Clin Mol Hepatol 2019;25:210-217)

KCI등재 SCOPUS

10VIEKIRA PAK associated drug-induced interstitial lung disease: Case series with systematic review of literature

저자 : Yu Jun Wong , Si Yuan Chew , John Chen Hsiang , Prem Harichander Thurairajah , Rahul Kumar , Eng Kiong Teo , Roshni Sadashiv Gokhale , Imran Bin Mohamed Noor , Jessica Tan

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 25권 2호 발행 연도 : 2019 페이지 : pp. 218-222 (5 pages)

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