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대한피부과학회지 update

Korean Journal of Dermatology

  • : 대한피부과학회
  • : 의약학분야  >  피부과학
  • : KCI등재
  • : SCOPUS
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수록정보
수록범위 : 1권1호(1960)~58권7호(2020) |수록논문 수 : 9,412
대한피부과학회지
58권7호(2020년 08월) 수록논문
최근 권호 논문
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KCI등재 SCOPUS

1켈로이드와 비대흉터에서 Fractional Carbon Dioxide Laser와 Intralesional Triamcinolone Acetonide 병용요법과 Intralesional Triamcinolone Acetonide 단독치료 효과비교: 체계적 문헌고찰 및 메타분석

저자 : 김우일 ( Woo Il Kim ) , 허재영 ( Jaeyoung Heo ) , 김수영 ( Sooyoung Kim ) , 조문균 ( Moon Kyun Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 7호 발행 연도 : 2020 페이지 : pp. 445-452 (8 pages)

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Background: Fractional carbon dioxide laser (FCL) has been used to treat keloid and hypertrophic scars as monotherapy or combination therapy, including intralesional triamcinolone acetonide (ITAC). However, whether the combination of FCL and ITAC is really effective compared with other treatments, such as ITAC monotherapy in treating keloid and hypertrophic scars, remains unclear.
Objective: To evaluate the effectiveness of FCL plus ITAC compared with ITAC monotherapy in treating keloid and hypertrophic scars.
Methods: A computerized search was performed in different databases, including Cochrane, Embase, and PubMed. One randomized controlled trial and two controlled clinical trials were included. Statistical analyses of the extracted outcome data from the studies were then calculated using the Rex Software (version 3.0.1).
Results: A total of 203 records were identified by searching databases, including Cochrane, Embase, and PubMed. The meta-analysis results, including three studies, demonstrated that although FCL combined with ITAC showed a slightly pronounced improvement in keloid and hypertrophic scars than ITAC monotherapy, there was no statistical difference (SMD: 0.26, 95% confidence interval [CI]: -0.10∼0.61, p=0.1541).
Conclusion: FCL combined with ITAC may not be a cost-effective treatment for the treatment of keloid and hypertrophic scars due to similar effectiveness compared with ITAC monotherapy. However, this study had limitations, including insufficiency of published articles and data. Therefore, further investigations are needed.
(Korean J Dermatol 2020;58(7):445∼452)

KCI등재 SCOPUS

2BCG 예방 접종 후 발생한 특이 피부 이상반응에 대한 임상 연구

저자 : 원상현 ( Sang-hyeon Won ) , 신기혁 ( Kihyuk Shin ) , 김우일 ( Woo-il Kim ) , 양민영 ( Min-young Yang ) , 이원구 ( Won-ku Lee ) , 김훈수 ( Hoon-soo Kim ) , 김병수 ( Byung-soo Kim ) , 김문범 ( Moon-bum Kim ) , 고현창 ( Hyun-chang Ko )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 7호 발행 연도 : 2020 페이지 : pp. 453-458 (6 pages)

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Background: Bacille Calmette-Guérin (BCG) vaccination has been widely used to prevent severe infections caused by Mycobacterium tuberculosis. Although BCG vaccination is generally safe, some cutaneous complications may occur. However, cutaneous complications related to BCG infection have been rarely investigated in Korea.
Objective: This study aimed to investigate the clinical characteristics of cutaneous complications following BCG vaccination in Korean patients.
Methods: We identified 18 patients with cutaneous complications following BCG vaccination in the Pusan National University Hospitals (Busan and Yangsan) from 2002 to 2019. Clinical manifestations and course were examined by the review of medical records and photographs.
Results: Among BCG-vaccinated persons, 18 patients manifested with BCG-specific cutaneous complications. The mean age of the patients was 10.6±10.1 months, and 10 (55.6%) were female. The specific cutaneous complications following BCG vaccination were local abscess (7, 38.9%), lymphadenitis (4, 22.2%), BCG reactivation in incomplete Kawasaki disease (4, 22.2%), tuberculid (3, 16.7%), and scrofuloderma (1, 5.6%). Disseminated BCG infection was detected in 2 brothers (11.1%) who had an immunocompromised state and a family history of BCG complication.
Conclusion: Specific cutaneous complications after BCG vaccination are rare, but may occur in various manifestations.
(Korean J Dermatol 2020;58(7):453∼458)

KCI등재 SCOPUS

3A Comparative Study for Evaluating the Diagnostic Capacity of the Dermatophyte Test Strip for Tinea Unguium

저자 : Ji Youn Hong , Sung Min Kim , Hye In Cheon , Yang Won Lee , Yong Beom Choe , Kyu Joong Ahn

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 7호 발행 연도 : 2020 페이지 : pp. 459-464 (6 pages)

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Background: Both direct microscopic examination and fungal culture are standard diagnostic methods for tinea unguium diagnosis. However, the accuracy of these tests is low and the results tend to be dependent on the skills of the performer. The Dermatophyte Test Strip, a newly developed diagnostic tool that is used to detect dermatophytes, facilitates the diagnosis of tinea unguium using immunochromatography.
Objective: We compared the diagnostic capacity of the Dermatophyte Test Strip and conventional diagnostic methods for the detection of dermatophytes in clinically suspected tinea unguium specimens in Korea.
Methods: Direct microscopic examination and the Dermatophyte Test Strip were performed on all specimens. If the results differed between the two methods, we used polymerase chain reaction (PCR) analysis to confirm the dermatophyte presence.
Results: Of the 120 specimens, 77 (64.2%) showed positive results on the Dermatophyte Test Strip and 66 (55.0%) on the direct microscopic examination. PCR analysis was performed on the 27 specimens whose results differed between the two tests, and all these specimens showed positive results on PCR analysis. When comparing the results of direct microscopy adjusted with PCR with those of the Dermatophyte Test Strip, the positive/negative/overall concordance rates were 100%, 81.4%, and 93.3%, respectively, while the kappa coefficient was 0.85 (95% confidence interval, 0.75∼0.95).
Conclusion: This study suggests that the Dermatophyte Test Strip, a practical diagnostic kit that detects dermatophytes without using other technical instruments, may be a valuable diagnostic tool for tinea unguium and may reduce the unnecessary use of antifungal agents. (Korean J Dermatol 2020;58(7):459∼464)

KCI등재 SCOPUS

4Correlation of Serum Inflammatory Cytokine Levels with Clinical Characteristics Including Severity in Korean Patients with Psoriasis

저자 : Jin Cheol Kim , Heera Lee , Soo Yeon Cho , Mi Jin Park , Eun-so Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 7호 발행 연도 : 2020 페이지 : pp. 465-471 (7 pages)

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Background: Psoriasis is a chronic relapsing inflammatory disease, with several cytokines related to its pathophysiology and clinical manifestations, such as disease activity, severity, and clinical subtype. However, there is limited information regarding Korean psoriasis patients.
Objective: We investigated the association between serum inflammatory cytokines and clinical characteristics of psoriasis, including treatment modalities.
Methods: We evaluated the serum Th17-related cytokine levels of 70 patients diagnosed with psoriasis using a multiplex immunoassay. All clinical information of patients was collected by reviewing electronic medical records and photo documentation in a retrospective manner.
Results: The serum IL-23 level was significantly higher in the young age group (<40 years), and the IL-6, TNF- β, and IL-28A levels were significantly higher in the early onset group (<40 years). In addition, patients with moderate-to-severe psoriasis (PASI≥10 and body surface area ≥10%) exhibited significantly lower serum IL-28A levels. We observed high serum TNF-α and CCL20 levels in patients with metabolic comorbidities and those with psoriatic arthritis, respectively, and biologics use and systemic treatment modality were also significantly associated with the serum levels of some cytokines.
Conclusion: Disease severity, comorbidities, presence of psoriatic arthritis, and treatment responsiveness might affect the inflammatory cytokine levels in psoriasis patients. Therefore, the serum cytokine levels can be used to predict the severity or treatment responsiveness of psoriasis patients. (Korean J Dermatol 2020;58(7):465∼471)

KCI등재 SCOPUS

5귀의 맞구슬에 발생한 단발성 섬유모낭종 1예

저자 : 구태한 ( Taehan Koo ) , 백가연 ( Gayun Baek ) , 박은정 ( Eunjung Park ) , 조민결 ( Mingyul Jo ) , 박지호 ( Ji-ho Park ) , 김민수 ( Min Soo Kim ) , 주민숙 ( Mihn-sook Jue )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 7호 발행 연도 : 2020 페이지 : pp. 472-475 (4 pages)

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Fibrofolliculoma is a benign perifollicular connective tissue tumor that usually occurs in the face. Most fibrofolliculoma present as multiple lesions and typically occur with trichodiscomas and acrochordons, constituting the Birt-Hogg-Dube syndrome. Solitary fibrofolliculoma is nonhereditary and unassociated with other cutaneous abnormalities. A 72-year-old man visited our clinic complaining of a solitary umbilicated nodule on the antitragus of the left ear. Skin biopsy from the lesion showed a central dilated follicular infundibulum with anastomosing bands of follicular epithelium extending into the fibrous stroma. The diagnosis of a solitary fibrofolliculoma was made based on the clinical and histopathological findings. No signs of lesion recurrence for 1 year after shave removal were noted. We report a rare case of solitary fibrofolliculoma that occurred on the antitragus of the ear. (Korean J Dermatol 2020;58(7):472∼475)

KCI등재 SCOPUS

6유전성 출혈성 모세혈관 확장증 1예

저자 : 류건욱 ( Geon Wook Ryu ) , 박형건 ( Hyung Keon Park ) , 이지범 ( Jee-bum Lee ) , 김성진 ( Seong-jin Kim ) , 이승철 ( Seung-chul Lee ) , 원영호 ( Young Ho Won ) , 윤숙정 ( Sook Jung Yun )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 7호 발행 연도 : 2020 페이지 : pp. 476-479 (4 pages)

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Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu syndrome, is a rare autosomal dominant genetic disorder that results in vascular malformation in the skin, mucous membrane, and other internal organs, such as the gastrointestinal tract, lung, liver, and brain. A 49-year-old man presented with purpuric punctate, spider-like telangiectasia on the face, hands, and fingers. He had episodes of recurrent nasal bleeding. The family members of the patient had similar events of recurrent nasal bleeding and cutaneous telangiectasia. Abdominal computed tomography revealed multiple arteriovenous malformations and cysts in the liver. Gastroendoscopy and colonoscopy showed angiodysplasia of the fundus of the stomach and mucous membrane of the colon. Histopathologic examination revealed dilated vessels lined with flat endothelial cells in the dermis. We report herein the case of HTT because it is rare and significant for differential diagnosis. (Korean J Dermatol 2020;58(7):476∼ 479)

KCI등재 SCOPUS

7손바닥에 발생한 기저세포암

저자 : 정의성 ( Eui-sung Jung ) , 박상우 ( Sang-woo Park ) , 이상경 ( Sang-kyung Lee ) , 남경화 ( Kyung-hwa Nam ) , 박진 ( Jin Park ) , 이내호 ( Nae-ho Lee ) , 윤석권 ( Seok-kweon Yun )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 7호 발행 연도 : 2020 페이지 : pp. 480-482 (3 pages)

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Basal cell carcinoma (BCC) is the most common type of skin cancer. It typically develops on sun-exposed and hair-containing areas of the body, such as the head and neck regions. The occurrence on the palms and soles is very rare. A 66-year-old Korean woman presented with a red elliptical ulcerative nodule on her left palm. Biopsy revealed basaloid cell mass and nests in the dermis with basal cells containing dark and elongated nuclei. She was diagnosed with basal cell carcinoma, and wide excision with full-thickness skin graft was performed. To the best of our knowledge, no case of basal cell carcinoma on the palm without basal cell nevus syndrome has been reported in Korean literature. Herein, we report this case owing to its rare occurrence on such location. (Korean J Dermatol 2020;58(7):480∼482)

KCI등재 SCOPUS

8비결핵성 항산균과 연관된 유육종증 1예

저자 : 석승휘 ( Seung Hui Seok ) , 신정우 ( Jung U Shin ) , 김현정 ( Hyun Jung Kim ) , 이희정 ( Hee Jung Lee ) , 윤문수 ( Moon Soo Yoon ) , 김동현 ( Dong Hyun Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 7호 발행 연도 : 2020 페이지 : pp. 483-486 (4 pages)

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Sarcoidosis is a multisystem granulomatous disease of unknown etiology. A range of factors including tuberculous infection, beryllium exposure, and cold climate have been implicated in the pathogenesis of the condition. A 45-year-old woman presented with a 4-month history of an asymptomatic eyelid swelling and multiple erythematous papules on the neck. Histological examination of the neck, orbital soft tissue, and lacrimal gland was consistent with sarcoidosis. Ziehl-Neelsen stains and polymerase chain reactions (PCRs) for tuberculosis on the skin biopsy specimens were negative. However, the orbital soft tissue specimen was positive for non-tuberculous mycobacteria (NTM) PCR. The patient was finally diagnosed with sarcoidosis associated with NTM. Treatment with systemic steroid and hydroxychloroquine was started, resulting in an improvement of skin lesions. We herein report a case of sarcoidosis associated with NTM infection with review of the literature, as only little is known regarding the role of mycobacteria in sarcoidosis. (Korean J Dermatol 2020;58(7):483∼486)

KCI등재 SCOPUS

9A Case of Lepromatous Leprosy in an Elderly Patient

저자 : Seung Ah Yoo , Chul Hwan Bang , Ju Hee Han , Ji Hyun Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 7호 발행 연도 : 2020 페이지 : pp. 487-488 (2 pages)

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Leprosy is an infectious disease caused by Mycobacterium leprae. Patients usually present with hypopigmented or erythematous plaques with central hypoesthesia or tenderness, and necessitate a differential diagnosis with eczema, granuloma annulare, sarcoidosis, syphilid, mycosis fungoides, erythema nodosum, and skin cancer. A 93-year-old woman presented with asymptomatic erythematous plaques and subdermal nodules on the face and extremities for 6∼ 7 months, and the lesions were suspicious for skin cancer. Histopathologic examination revealed diffuse infiltration of foamy histiocytes separated by a grenz zone. Acid-fast bacilli were seen in Ziehl-Neelsen stain with clumps called globi. Based on clinical and histopathological findings, she was finally diagnosed with lepromatous leprosy. The patient was diagnosed with leprosy at an advanced age; thus, we report the case in which dermatologists should consider leprosy as well as skin cancer in the elderly patients with unusual erythematous nodules, despite decreasing prevalence of leprosy. (Korean J Dermatol 2020;58(7):487∼488)

KCI등재 SCOPUS

10낭성 모모세포종 1예

저자 : 권형목 , 김혜리 , 신동훈 , 최종수 , 배영경

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 58권 7호 발행 연도 : 2020 페이지 : pp. 489-490 (2 pages)

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1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

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