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대한피부과학회지 update

Korean Journal of Dermatology

  • : 대한피부과학회
  • : 의약학분야  >  피부과학
  • : KCI등재
  • : SCOPUS
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수록정보
수록범위 : 1권1호(1960)~55권9호(2017) |수록논문 수 : 8,878
대한피부과학회지
55권9호(2017년) 수록논문
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KCI등재 SCOPUS

1주사 환자에서 경구 메트로니다졸 치료의 효용성에 대한 고찰

저자 : 한석현 ( Seok Hyun Han ) , 서호석 ( Ho Seok Suh ) , 최유성 ( Yu Sung Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 9호 발행 연도 : 2017 페이지 : pp. 557-564 (8 pages)

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Background: Recent studies have revealed that several factors including Demodex mites induce an excessive immune response and that the skin lesions seen in patients with rosacea may develop as a result of excessive inflammation. Therefore, acaricidal and anti-inflammatory treatments such as systemic metronidazole have been shown to be efficacious for rosacea. Objective: This study aimed to evaluate the efficacy of systemic metronidazole in the treatment of rosacea. Methods: A group of 39 patients diagnosed with rosacea who visited the Department of Dermatology of Ulsan University Hospital from April 2014 to July 2015 was investigated in this single-center retrospective study. Patients were treated with metronidazole 250 mg 3 times daily for 3 weeks. The response was evaluated using serial photographs of the patients. According to clinical improvement, patients were classified into an effective group and a failure group. Results: After treatment, 29 patients (74.4%) responded to systemic metronidazole treatment. Fourteen patients (48.3%) in the effective group were well controlled without recurrence for 20.1 weeks. Patients in the effective group showed a higher detection rate of Demodex mites and proportion of the papulopustular rosacea subtype than patients in the failure group. Conclusion: The results of this study showed that systemic metronidazole was a tolerable and effective option for the treatment of patients with papulopustular rosacea with Demodex mites. Moreover, the early treatment of inflammatory lesions leads to an improved prognosis. (Korean J Dermatol 2017;55(9):557∼564)

KCI등재 SCOPUS

2성별과 중증도에 따른 건선의 임상적, 병리조직학적 및 면역조직화학적인 특성: 에스트로겐의 역할에 대한 연구

저자 : 양지영 ( Ji Young Yang ) , 박영준 ( Young Joon Park ) , 정수은 ( Soo-eun Jung ) , 박미진 ( M

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 9호 발행 연도 : 2017 페이지 : pp. 565-571 (7 pages)

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Background: Psoriasis is a chronic inflammatory skin disorder histopathologically characterized by epidermal hyperplasia, vascular proliferation, and inflammatory infiltrates. It runs a less severe course in women than in men. The role of estrogen in the pathogenesis of psoriasis remains unclear. Objective: We investigated the clinicohistopathological differences between men and women with psoriasis and examined whether serum estrogen levels and immunohistochemical findings correlate with gender and disease severity. Methods: We retrospectively reviewed the medical records of 500 patients with psoriasis. Among these patients, 60 who consented to participate in the study were classified into four groups as follows: 10 men showing psoriasis on <10% of their body surface area (BSA) with psoriasis area severity index (PASI)<10; 20 men showing psoriasis on ≥10% of their BSA with PASI≥10; 10 women showing psoriasis on <10% of their BSA with PASI<10; and 20 women showing psoriasis on ≥10% of their BSA with PASI ≥10. Serum estrogen levels were measured using radioimmunoassay. Immunohistochemical staining of skin biopsy tissues was performed using ERα, ERβ, and CCL5. Results: Men diagnosed with psoriasis showed higher BSA and PASI scores than women. Women aged ≥60 years showed higher BSA and PASI scores than women aged <60 years. There were no histological differences between the four groups. Serum estrogen levels were higher in the patients presenting with mild psoriasis, as well as in women. ERα, ERβ, and CCL5 showed a stronger staining tendency in patients with more severe psoriasis. Conclusion: Gender influences the severity of psoriasis, and estrogen plays an important role. This finding is explained by the fact that estrogen decreases inflammation in psoriasis possibly via its action on estrogen receptors in epidermal keratinocytes. (Korean J Dermatol 2017;55(9):565∼571)

KCI등재 SCOPUS

3여드름 환자의 삶의 질에 대한 고찰: 10년 전과 비교

저자 : 신요섭 ( Yo Sup Shin ) , 이민경 ( Min Kyung Lee ) , 박복원 ( Bok Won Park ) , 조은별 ( Eun B

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 9호 발행 연도 : 2017 페이지 : pp. 572-579 (8 pages)

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Background: Acne has been found to be associated with psychosocial problems, and the influence of acne may vary according to the era. Objective: We aimed to compare the present quality of life (QOL) of acne patients with that in the past 10 years. Additionally, financial values that patients attach to the treatment of their acne were evaluated. Methods: We analyzed the influences of acne on QOL using self-reported validated questionnaires (WHOQOL-BREF, Skindex-29, APSEA, CADI) between June 2014 and December 2015. Results: 100 acne patients and 70 controls were enrolled in the study. Compared with that in the past 10 years, the quality of life of acne patients decreased in terms of psychological and social relationships, and the difference between males and females was reduced. Clinical characteristics associated with quality of life were identified as age, duration, education, and self-reported severity score, etc. Patient-based financial valuation of treatment costs was associated with the Skindex-29, WHOQOL-BREF, and CADI scores. Conclusion: The impact of acne on QOL, especially psychosocial aspects, is important, and early initiation of the appropriate treatment may help to address the diminished QOL and financial burden of acne patients. (Korean J Dermatol 2017;55(9):572∼579)

KCI등재 SCOPUS

4광노화 병변의 유병률 조사 및 단일성과 다발성 광선각화증 환자들의 특성 비교: 환자 61명에 대한 후향적 연구

저자 : 고병용 ( Byoung Yong Koh ) , 명기범 ( Ki Bum Myung ) , 한형진 ( Hyung Jin Hahn ) , 정승현 (

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 9호 발행 연도 : 2017 페이지 : pp. 580-587 (8 pages)

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Background: Photoaged skin is characterized by actinic skin lesions such as wrinkling, elastosis, and premalignant and malignant lesions. Actinic keratosis (AK) is one of the most common precancerous lesions, and multiple actinic keratosis lesions are one of the risk factors for skin cancer. Few studies have investigated the prevalences of actinic skin lesions and compared the characteristics of the lesions and the patients with sinle and multiple AK lesions. Objective: The aim of this study was to evaluate the prevalences of actinic skin lesions and to compare characteristics between single and multiple lesions in Korean patients with AK. Methods: We retrospectively reviewed the medical records and biopsy specimens of 61 patients. Results: Frequencies of deep wrinkle, solar elastosis, cutis rhomboidalis nuchae, and senile purpura were higher in the multiple lesions group. The ratio of males to females was 1:3.43 and the mean age was 79 years in the multiple lesions group, both of which were higher than those in the single lesion group (1:1.14, 72 years). The mean duration was longer in the multiple lesions group. Sun protective behavior was more frequent in the single lesion group, and the occupation of farmer was more common in the multiple lesions group. There was no statistically significant clinicopathological difference between the two groups. Conclusion: This study may improve our understanding of the characteristics of actinic keratosis with both single and multiple lesions. (Korean J Dermatol 2017;55(9):580∼587)

KCI등재 SCOPUS

5임신선에 관한 대학 병원 피부과 외래 환자의 인식도, 유병율 및 특징 설문조사

저자 : 최훈 ( Hoon Choi ) , 김윤수 ( Yoon Soo Kim ) , 김민성 ( Min Sung Kim ) , 나찬호 ( Chan Ho N

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 9호 발행 연도 : 2017 페이지 : pp. 588-596 (9 pages)

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Background: Striae gravidarum (SG) is a common skin change that occurs in pregnancy. Various risk factors associated with SG have been reported, but the results are controversial. Objective: This study aimed to determine the incidence, clinically associated factors, and awareness of SG in postpartum women at the dermatology clinic of a university hospital. Methods: A questionnaire-based survey was conducted on women with fertility histories who had visited the dermatologic clinic of our hospital from October 2015 to December 2016. The survey items included the time of SG appearance, maternal age, and factors related to the development of SG (e.g., maternal weight gain, fetal weight and sex, and family history). We also investigated the awareness of SG development and treatment, and excluded subjects with various diseases that could affect SG. Results: The subjects were 38 primiparas and 62 multiparas, and SG was observed in 91 subjects (91%). In 55.9% of the primiparous women, the SG became evident in the second trimester, although 63.1% of the multiparous women experienced the development of SG in the third trimester. There was a statistically significant difference in the time of SG appearance between primiparas and multiparas. In addition, fetal weight, maternal weight gain, and family history of SG were statistically associated with the occurrence of SG. However, fetal sex was not related to SG. The pregnant women considered the weight gain during pregnancy to be the most common cause of SG, while family history, fetal overweight, and the use of cream for skin regeneration were thought to be other causes of SG. 53.8% of the subjects with SG experienced various treatment methods, which did not show any significant difference in terms of effectiveness when compared with non-treated subjects. Conclusion: In our study, maternal weight gain, family history, and fetal weight were statistically significantly associated with the development of SG. We believe that this study may be useful to enhance our understanding of the awareness, prevalence, and related factors of SG in dermatologic outpatients at a university hospital. Multi-center studies with large numbers of patients are warranted to further investigate the clinical features of SG. (Korean J Dermatol 2017;55(9):588∼596)

KCI등재 SCOPUS

6면역억제환자에서 발생한 범발성 편평사마귀를 경구 아시트레틴과 국소 5% Imiquimod Cream 병합요법으로 효과적으로 치료한 1예

저자 : 임재윤 ( Jae-yun Lim ) , 김한샘 ( Han-saem Kim ) , 김정인 ( Jung-in Kim ) , 민준홍 ( Joon Ho

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 9호 발행 연도 : 2017 페이지 : pp. 597-601 (5 pages)

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Verruca plana is a subtype of warts, which are one of the most common dermatological diseases. A 37-year-old man presented with multiple asymptomatic skin-colored, 1∼2-mm, flat-topped papules on both arms, neck, and face. The patient had ulcerative colitis, which had been treated with immunosuppressants for 15 years. After skin biopsy, verruca plana was confirmed. The patient was treated with 5% imiquimod cream for 6 months. However, only mild improvement was observed. Acitretin was then added to the treatment regimen. After 44 weeks of treatment, acitretin was stopped. Dramatic and rapid clinical improvement was achieved after 3 weeks of treatment, and no sign of recurrence after treatment cessation has been reported for 60 weeks. Consequently, the combination of oral acitretin and topical 5% imiquimod cream should be recommended for the effective and safe treatment of recalcitrant verruca plana in immunosuppressed patients. (Korean J Dermatol 2017;55(9):597∼601)

KCI등재 SCOPUS

7선천성 모세혈관 확장성 대리석양 피부 2예

저자 : 김수정 ( Sue-jeong Kim ) , 하정민 ( Jeong-min Ha ) , 임명 ( Myung Im ) , 서영준 ( Young Joo

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 9호 발행 연도 : 2017 페이지 : pp. 602-605 (4 pages)

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Cutis marmorata telangiectatica congenita (CMTC) is a rare congenital vascular disorder. The skin lesions associated with CMTC include persistent, reticulated vascular patches and telangiectasia, and they are sometimes associated with underlying atrophy and ulceration. The condition is present at birth and tends to improve with age, although some skin lesions remain unchanged throughout life. We encountered two patients with CMTC: a 12-day-old infant and a 21-year-old woman with a history of CMTC since birth. Both patients had localized reticulated purpuric patches with atrophy. During follow-up, although the purpuric patches improved in both patients, there were no changes in the skin atrophy in either patient. Herein, we present these cases showing the changes in the cutaneous features of CMTC over time and demonstrate that CMTC at birth may persist throughout life. (Korean J Dermatol 2017;55(9):602∼605)

KCI등재 SCOPUS

8전신 스테로이드제 투여 환자에서 빠른 속도로 악화된 카포시육종 1예

저자 : 이호열 ( Ho Yeol Lee ) , 우청하 ( Cheong Ha Woo ) , 박혜진 ( Hai-jin Park ) , 허식 ( Sik Ha

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 9호 발행 연도 : 2017 페이지 : pp. 606-609 (4 pages)

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Kaposi's sarcoma (KS) is a vascular neoplasm originating from vascular and lymphatic endothelial cells. Iatrogenic KS mainly develops in organ transplant patients or after receiving immunosuppressive therapy. An 81-year-old man presented with multiple dark-purplish nodules, plaques, and patches on the right leg for 3 weeks. Previously, the patient was treated with prednisolone 10∼30 mg/day for chronic obstructive pulmonary disease for 3 months, and percutaneous transluminal angioplasty was performed 1 month previously for the treatment of peripheral arterial occlusive disease. A biopsy specimen of the nodule showed closely packed spindle cells forming slit-like vascular structures, which were consistent with KS. Despite the dosage reduction of prednisolone for treatment, the skin lesions progressed aggressively throughout the entire body, and the patient died after 5 months. We report a case of iatrogenic prednisolone-associated KS rapidly progressing to the entire body shortly thereafter. (Korean J Dermatol 2017;55(9):606∼609)

KCI등재 SCOPUS

9손바닥에 발생한 원발 피부 역형성 대세포 림프종 1예

저자 : 김병수 ( Byeong Su Kim ) , 유문형 ( Moon Hyung You ) , 김준군 ( Joon Goon Kim ) , 김연웅 ( Y

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 9호 발행 연도 : 2017 페이지 : pp. 610-614 (5 pages)

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Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare primary cutaneous lymphoma that is predominantly composed of large lymphoid cells that express the CD30 antigen. The skin lesion of PCALCL is usually single, ulcerative, and located on the trunk or extremities and rarely the palm. A 25-year-old woman presented with a plaque on the left palm for 20 days. The plaque was walnut-sized and purple to gray colored with erosion in the center. Histopathologic examination showed infiltration of large atypical cells in the dermis. The large tumor cells showed positivity for CD3, CD4, and CD30 and negativity for CD8, CD20, epithelial membrane antigen, and anaplastic lymphoma kinase. PET-CT showed no other hypermetabolic lesion except that on the left palm, and we finally arrived at a diagnosis of PCALCL. The patient was treated with an intralesional injection of methotrexate (25 mg/mL, 0.45 cc). After 3 months of treatment, the walnut-sized plaque had disappeared and a peripheral hyperpigmented patch remained. (Korean J Dermatol 2017;55(9):610∼614)

KCI등재 SCOPUS

10모모세포종과 복합모반을 동반한 피지샘 모반

저자 : 오수진 ( Su Jin Oh ) , 한성수 ( Sung Soo Han ) , 박형권 ( Hyung Kwon Park ) , 유희준 ( Hee J

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 9호 발행 연도 : 2017 페이지 : pp. 615-618 (4 pages)

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Nevus sebaceous is a common congenital cutaneous hamartoma occurring mainly on the face and scalp. It is well known that secondary neoplasms can be easily observed in the primary lesion. However, a case of trichoblastoma and compound nevus concurrently arising from nevus sebaceous has not been previously reported. A 26-year-old woman presented with a well-demarcated atrophic skin-colored plaque on her scalp from birth. On the plaque, a black dome-shaped round nodule and a brownish nodule with irregular margins were found one week previously without subjective symptoms. Histopathological examination of the central plaque lesion revealed epidermal hyperplasia and hyperplasia of the sebaceous glands and eccrine glands. In addition, ectopic, dilated apocrine glands were revealed in the lower dermis, and the hair follicles remained small and primordial, consistent with nevus sebaceous. A section of the black nodule showed palisading basaloid cells surrounded by abundant fibrous stroma. Nests of nevus cells were found at the dermo-epidermal junction and dermis in the brownish nodule. Based on these findings, the black nodule and brownish nodule were diagnosed as trichoblastoma and compound nevus, respectively. Herein, we report an interesting case of trichoblastoma and compound nevus concurrently arising from nevus sebaceous, which is, to our knowledge, the first such report in the dermatologic literature. (Korean J Dermatol 2017;55(9):615∼618)

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(2006)홍길동41회 피인용

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