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대한피부과학회지 update

Korean Journal of Dermatology

  • : 대한피부과학회
  • : 의약학분야  >  피부과학
  • : KCI등재
  • : SCOPUS
  • : 연속간행물
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  • : 0494-4739
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수록정보
수록범위 : 1권1호(1960)~57권5호(2019) |수록논문 수 : 9,176
대한피부과학회지
57권5호(2019년) 수록논문
최근 권호 논문
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KCI등재 SCOPUS

1안면부 대상포진에 대한 15년간의 후향적 연구: 단일 기관에서의 경험

저자 : 서중헌 ( Joong Heon Suh ) , 이수경 ( Soo Kyung Lee ) , 이운하 ( Un Ha Lee ) , 김명신 ( Myoung Shin Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 5호 발행 연도 : 2019 페이지 : pp. 235-242 (8 pages)

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Background: Many studies about herpes zoster exist in the Korean dermatologic literature. However, few studies have reported about facial herpes zoster and its complications.
Objective: The purpose of this study was to investigate the epidemiology, clinical features, and complications of facial herpes zoster.
Methods: We analyzed the medical records of 977 patients who visited Sanggye Paik Hospital between January 2002 and December 2017. We categorized patients into 8 groups based on the dermatomal distribution of herpetic lesions. We investigated the correlations between clinical features, prognosis, and complications.
Results: The most common site of involvement of facial herpes zoster was the ophthalmic branch of the trigeminal nerve (59.2%). Herpes zoster involving the ophthalmic and the maxillary branches of the trigeminal nerves showed a significantly higher incidence rate of herpes zoster ophthalmicus than that observed with herpes zoster involving only the ophthalmic branch (odds ratio 7.373). Age and periorbital swelling were significantly correlated with herpes zoster ophthalmicus (p<0.001). Facial palsy was significantly correlated with otalgia and cutaneous ear involvement (p<0.001). Postherpetic neuralgia (PHN) occurred in 41% of patients with facial herpes zoster. Patients who received antiviral treatment within 3 days showed lower rates of PHN (35.8%) than patients who received treatment after 4 days (45.4%) (p=0.002).
Conclusion: Facial herpes zoster is associated with several neurological complications. Variables including age, periorbital swelling, otalgia, and cutaneous ear involvement are useful predictors of complications and prognosis. Early institution of antiviral treatment and appropriate interdepartmental consultations are required for better treatment outcomes. (Korean J Dermatol 2019;57(5):235∼242)

KCI등재 SCOPUS

2성인 황색육아종의 임상, 병리조직 및 면역조직화학적 연구

저자 : 곽현빈 ( Hyun-bin Kwak ) , 정의성 ( Eui Sung Jung ) , 박상우 ( Sang-woo Park ) , 윤석권 ( Seok-kweon Yun )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 5호 발행 연도 : 2019 페이지 : pp. 243-250 (8 pages)

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Background: Juvenile xanthogranuloma is a benign, self-limited disorder that usually occurs in infants and young children. Xanthogranuloma is rare in adults, and therefore studies reporting adult xanthogranuloma are limited.
Objective: We investigated the clinical, histopathological, and immunohistochemical characteristics of adult xanthogranuloma.
Methods: In this study, we evaluated 20 lesions in 19 patients with adult xanthogranuloma.
Results: A male predominance was observed (male:female ratio 1.4:1), and the mean age of patients was 35.1±16.3 years (range 15∼66 years), with the peak incidence observed in patients in their 20s. Notably, 65.0% of the lesions developed on the head and neck. The nodular form was more common than the papular form of this condition. Histopathological examination revealed dense monomorphic histiocytic infiltration without lipidization and scattered eosinophils without multinuclear giant cells in 5 lesions (25.0%), foamy histiocytic infiltration with variations of completely developed Touton giant cells in 10 lesions (50.0%), and fibrohistiocytic proliferation in 3 lesions (15.0%). On immunohistochemical examination, histiocytes including giant cells showed positive test results with Factor XIIIa (90.9%), vimentin (100%), and CD68 (100%) and negative test results with CD1a, smooth muscle actin, and S-100 protein stains. Tumor excision was the treatment for choice.
Conclusion: Adult xanthogranuloma most commonly manifested as the nodular form of the disease on the head and neck of men in their late 20s. Histopathologically, the classic Touton cell-rich stage was most commonly observed, followed by the stage of early predominantly mononuclear infiltration. This was a single-center, small-sized retrospective study; however, we expect the results of this study to contribute to a better understanding of adult xanthogranuloma. (Korean J Dermatol 2019;57(5):243∼250)

KCI등재 SCOPUS

3Efficacy of a Hair Tonic Containing Human Umbilical Cord Blood Mesenchymal Stem Cell-derived Conditioned Media in Patients with Androgenetic Alopecia

저자 : Hye Sung Han , Kui Young Park , Eun Jung Ko , Beom Joon Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 5호 발행 연도 : 2019 페이지 : pp. 251-257 (7 pages)

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Background: The development of a safe and convenient agent that can promote hair growth in patients with androgenetic alopecia remains challenging.
Objective: This study was designed to investigate the efficacy of a newly developed hair tonic containing a human umbilical cord blood mesenchymal stem cell (hUCB-MSC)-derived conditioned medium in promoting hair growth.
Methods: This double-blind, placebo-controlled clinical study investigated the efficacy of a hair tonic containing an hUCB-MSC-derived conditioned medium in 30 patients with patterned hair loss. Treatment efficacy was determined using phototrichograms to evaluate the density, diameter, and hair growth rate at baseline levels and after 4, 8, and 16 weeks of treatment.
Results: The hair density in the group treated with the hair tonic significantly increased from 125.2 to 134.6 hairs/㎠ (p<0.05). In this same group, the thickness of hair also increased from 0.083 to 0.110 mm (p<0.05). Additionally, the hair growth rate increased from 0.285 to 0.338 mm/day (p<0.05). No severe adverse reactions were reported.
Conclusion: A hair tonic containing an hUCB-MSC-derived conditioned medium could be a new effective alternative to treat patients with androgenetic alopecia. (Korean J Dermatol 2019;57(5):251∼257)

KCI등재 SCOPUS

4Vanishing Bile Duct Syndrome과 동반되어 나타난 Stevens-Johnson Syndrome 1예

저자 : 안지혜 ( Ji Hae An ) , 이선구 ( Seon Gu Lee ) , 김동현 ( Dong Hyun Kim ) , 윤문수 ( Moon Soo Yoon ) , 이희정 ( Hee Jung Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 5호 발행 연도 : 2019 페이지 : pp. 258-261 (4 pages)

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Stevens-Johnson syndrome (SJS) is a serious and potentially life-threatening disease. Vanishing bile duct syndrome (VBDS) is a rare cause of progressive cholestasis. Both syndromes are usually associated with the use of specific drugs. VBDS in patients with SJS is most commonly associated with drug hypersensitivity. To our knowledge, to date, the literature contains only a single report of toxic epidermal necrolysis associated with VBDS in Korea. We report a case of drug-induced SJS with acute onset of VBDS and present a review of the literature in this context. This case highlights the importance of awareness among clinicians regarding drug reactions, their severity, as well as diagnostic modalities and optimal management strategies in these cases. (Korean J Dermatol 2019;57(5):258∼261)

KCI등재 SCOPUS

5흉부에 발생한 섬유 탄력섬유용해구진증

저자 : 박근휘 ( Geun-hwi Park ) , 이현주 ( Hyun Joo Lee ) , 김훈수 ( Hoon-soo Kim ) , 고현창 ( Hyun-chang Ko ) , 김병수 ( Byung Soo Kim ) , 김문범 ( Moon-bum Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 5호 발행 연도 : 2019 페이지 : pp. 262-264 (3 pages)

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Fibroelastolytic papulosis is an acquired elastic tissue disorder that includes the clinicopathological features of white fibrous papulosis of the neck (WFPN) and pseudoxanthoma elasticum-like papillary dermal elastosis (PXE-PDE). It is clinically characterized by discrete white papules occurring on the neck in middle-aged women and is histopathologically characterized by elastolysis and/or fibrosis in the upper dermis. An 80-year-old woman presented with multiple white papules on her anterior chest, which occurred 6 months prior to the presentation. Histopathological examination of a biopsy specimen revealed some degree of fibrosis and elastolysis in the upper dermis. Thus, the final diagnosis in this case was compatible with fibroelastolytic papulosis considering that this patient showed clinicopathological features of both WFPN and PXE-PDE. Notably, this is the first case report that describes fibroelastolytic papulosis confined exclusively to the anterior chest. (Korean J Dermatol 2019;57(5):262∼264)

KCI등재 SCOPUS

6항 섬유화 제제로서의 국소 이미퀴모드 5% 크림으로 임상적 호전을 보인 섬유화성 질환 3예

저자 : 조여례 ( Yeo-rye Cho ) , 김호진 ( Ho-jin Kim ) , 서정완 ( Jeong-wan Seo ) , 김태훈 ( Tae-hoon Kim ) , 김기호 ( Ki Ho Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 5호 발행 연도 : 2019 페이지 : pp. 265-269 (5 pages)

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Imiquimod, a toll-like receptor agonist, is a topical immunomodulator that induces the production of several cytokines including interferon-alpha, which shows antifibrotic properties. We hypothesized that the antifibrotic effect of imiquimod would soften fibrotic skin lesions. Therefore, we applied topical imiquimod with topical tacrolimus or systemic acitretin in patients with refractory lesions of myxedema, angiolymphoid hyperplasia, and generalized discoid lupus erythematosus and confirmed improvement in fibrotic lesions in these patients. Thus, we conclude that use of imiquimod improves fibrotic skin lesions. This report describes our experience with the treatment of this condition along with a review of the related literature. (Korean J Dermatol 2019;57(5):265∼269)

KCI등재 SCOPUS

7만성신부전증에서 혈액투석으로 변경 후 호전을 보인 다발성 전이성 피부 석회증 1예

저자 : 최인혜 ( In Hye Choi ) , 박철종 ( Chul Jong Park ) , 이경호 ( Kyung Ho Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 5호 발행 연도 : 2019 페이지 : pp. 270-273 (4 pages)

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Metastatic calcinosis cutis refers to the deposition of calcium salts in normal tissue secondary to an underlying defect in calcium and/or phosphate metabolism. It commonly affects periarticular areas in patients with chronic renal failure. We report a case of a 51-year-old man with a past medical history of peritoneal dialysis for chronic renal failure, who presented with multiple yellowish nodules on his right thumb. In view of the asymptomatic non-inflamed fluctuating nodules, the differential diagnoses included bacterial, tuberculous, atypical mycobacterial, or fungal infections. Histopathological and radiological examinations revealed calcifications in the right thumb and shoulder with elevated serum phosphorus and parathyroid hormone levels. The lesions improved after the patient was switched from peritoneal dialysis to hemodialysis. We report a case of metastatic calcinosis cutis in a patient with chronic renal failure. We emphasize the importance of imaging for accurate diagnosis and follow-up of calcinosis cutis and that hemodialysis scores over peritoneal dialysis in the treatment of this condition. (Korean J Dermatol 2019;57(5):270∼273)

KCI등재 SCOPUS

8피부 병변으로 발현한 비정형 기형/횡문근양 종양 1예

저자 : 홍승기 ( Seung Gi Hong ) , 조선영 ( Sun Young Jo ) , 노기웅 ( Ki Woong Ro ) , 허은필 ( Eun Phil Heo )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 5호 발행 연도 : 2019 페이지 : pp. 274-278 (5 pages)

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An atypical teratoid/rhabdoid tumor (AT/RT) is a rare malignancy occurring in the first few years of life. This tumor shows rapid growth, a poor response to treatment, and poor prognosis. Cutaneous metastases presents as hamartomatous lesions mimicking skin tags. Immunohistochemical examination shows varied patterns of expression based on the sites of the body affected. Integrase interactor-1 (INI-1) gene sequencing and loss of expression of INI-1 observed with immunostaining can confirm AT/RT. In our patient, the skin lesion was identified at birth. Histopathological examination of the skin lesion could not establish an accurate diagnosis. Two months later, the patient presented with a brain tumor. Immunohistochemical examination of the brain lesion revealed complete loss of INI-1 expression in tumor cells, and the lesion was diagnosed as AT/RT. After that, we can detect the loss of INI-1 expression in the skin on the back. We report a rare case of AT/RT affecting the brain with cutaneous metastasis diagnosed with immunohistochemical staining. (Korean J Dermatol 2019;57(5):274∼278)

KCI등재 SCOPUS

9골성 화생을 보인 기저세포암 1예

저자 : 유대산 ( Dae San Yoo ) , 박세현 ( Seh Hyun Park ) , 노미령 ( Mi Ryung Roh )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 5호 발행 연도 : 2019 페이지 : pp. 279-280 (2 pages)

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KCI등재 SCOPUS

10흑색종과 유사한 임상양상을 보인 흑연 육아종 1례

저자 : 정국진 ( Guk Jin Jeong ) , 김재민 ( Jae Min Kim ) , 이갑석 ( Kap sok Li )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 5호 발행 연도 : 2019 페이지 : pp. 281-282 (2 pages)

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(2006)홍길동 외 1명심리학41회 피인용

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