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한국약제학회> PROCEEDINGS OF THE FIP POST-SATELLITE SYMPOSIUM `93 SEOUL : PHARMACEUTICAL EXCIPIENTS

PROCEEDINGS OF THE FIP POST-SATELLITE SYMPOSIUM `93 SEOUL : PHARMACEUTICAL EXCIPIENTS

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수록정보
수록범위 : 0권0호(1993) |수록논문 수 : 9
PROCEEDINGS OF THE FIP POST-SATELLITE SYMPOSIUM `93 SEOUL : PHARMACEUTICAL EXCIPIENTS
0권0호(1993년) 수록논문
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These days, it is not uncommon that a same kind of drug is circulated globally. However, the qualities of excipients used in the same drug have to be sometimes different depending on the different requirements in the qualities stipulated by each country. For a supplier of pharmaceutical excipients, it is generally necessary to carry out different tests on the same kind of testing criteria depending on the country of destination. Thus, the discrepancies between compendium requirements of pharmaceutical excipients create severe problems in various area of industrial activities. The decision of the United States Pharmacopoeia, European Pharmacopoeia and Japanese Pharmacopoeia Commissions to harmonize the requirements is a unique chance for the industries to overcome these problems. On the other hand, discrepancies of general test methods and requirements in each monograph of pharmaceutical excipient between the compendia valid at present are in most cases extensive. Consequently their harmonization needs a lot of detailed work requiring strong support from the industry. Based on these circumstances, pharmaceutical excipients councils have been established first in U.S.A. and successively in Europe and in Japan to contribute to the harmorization process. We should like to review here the progress since the Orlando Conference in 1991 and comment about the matters at issue with regard to the international harmonization of pharmaceutical excipients.

3Bioequivalence and Scale - Up of Solid Oral Dosage Forms

저자 : Choon Kyung Oh , S . Kathy Edmond Rouan

발행기관 : 한국약제학회 간행물 : PROCEEDINGS OF THE FIP POST-SATELLITE SYMPOSIUM `93 SEOUL : PHARMACEUTICAL EXCIPIENTS 0권 0호 발행 연도 : 1993 페이지 : pp. 23-32 (10 pages)

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4Enhanced Bioavailability of Poorly Water - Soluble Drugs Using Dry Elixir

저자 : Chong Kook Kim , Yong Sang Yoon , Jae Yoon Choi , Beom Jin Lee

발행기관 : 한국약제학회 간행물 : PROCEEDINGS OF THE FIP POST-SATELLITE SYMPOSIUM `93 SEOUL : PHARMACEUTICAL EXCIPIENTS 0권 0호 발행 연도 : 1993 페이지 : pp. 33-39 (7 pages)

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The iontophoretic delivery across rat skin of quaternary ammonium salts (isopropamide: ISP, pyridostigmine: PS), which are positively charged over a wide pH range, was measured in vitro. The study showed that: (a) iontophoresis significantly enhanced delivery of ISP and PS compared to respective passive transport; (b) delivery of ISP and PS was directly proportional to the applied continuous direct current density over the range of 0-0.69 mA/㎠; (c) delivery of ISP and PS was also proportional to the drug concentration in the donor compartment over the range of 0-2×10^(-2) M; (d) sodium ion in the donor compartment inhibited the drug transport possibly due to decreasing the electric transference number of the drug; (e) delivery of ISP and PS increased as the pH of the donor solution increased over the pH range 2-7 suggesting permselective nature of the epidermis, and inhibition of the transference number of the drugs by hydronium ion; (f) some organic anions such as taurodeoxycholate, salicylate and benzoate which form lipophilic ion-pair complexes with ISP inhibited the delivery of ISP. The degree of inhibition by the organic anions was linearly proportional to the extraction coefficient (K_c) of ISP from the partition system with each counteranion between phosphate buffer (pH 7.4) and n-octanol. For PS, however, taurodeoxycholate, but not salicylate and benzoate inhibited the iontophoretic delivery. It suggests that not only sodium ion and hydronium ion but also the counteranions which form lipophilic ion-pairs with quaternary ammonium drugs are not favorable components in formulating the donor solution of the drugs to achieve an effective iontophoretic delivery.

7Excipients in Development of Topical Drug Delivery Systems

저자 : Yoshiharu Machida

발행기관 : 한국약제학회 간행물 : PROCEEDINGS OF THE FIP POST-SATELLITE SYMPOSIUM `93 SEOUL : PHARMACEUTICAL EXCIPIENTS 0권 0호 발행 연도 : 1993 페이지 : pp. 67-70 (4 pages)

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8Polyvinylpyrrolidone-A Versatile Product in Pharmaceutical Technology

저자 : Siegfried Lang

발행기관 : 한국약제학회 간행물 : PROCEEDINGS OF THE FIP POST-SATELLITE SYMPOSIUM `93 SEOUL : PHARMACEUTICAL EXCIPIENTS 0권 0호 발행 연도 : 1993 페이지 : pp. 71-92 (22 pages)

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9Cyclodextrins : The All-purpose Excipients of Tomorrow

저자 : D . Duchene , D . Wouessidjewe

발행기관 : 한국약제학회 간행물 : PROCEEDINGS OF THE FIP POST-SATELLITE SYMPOSIUM `93 SEOUL : PHARMACEUTICAL EXCIPIENTS 0권 0호 발행 연도 : 1993 페이지 : pp. 93-100 (8 pages)

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