간행물

한국약제학회> DDS 연구를 통한 신약개발

DDS 연구를 통한 신약개발

  • : 한국약제학회
  • : 의약학분야  >  약품제제
  • :
  • :
  • : 단행본
  • : 기타
  • :
  • :
  • :

수록정보
수록범위 : 0권0호(1992) |수록논문 수 : 2
DDS 연구를 통한 신약개발
0권0호(1992년) 수록논문
최근 권호 논문
| | | |

다운로드

(기관인증 필요)

키워드 보기
초록보기

Two different types of chemical manipulations of dobutamine were investigated in order to develop novel, improved cardiotonic drugs. Three new analogues of carbostyril, in which the m-hydroxy group of dobutamine was isosterically modified with an amide type carbostyril system, were synthesized fron. p-methoxyphenethylamine via multi-steps. Two analogues of (2`-aminoethyl)-1-hydroxy-2-pyridone system which has isosteric structural similarity with dopamine without having the COMT vulnerable m-hydroxy group were synthesized via 12 synthetic steps. Their biological stabilities in various media and inotropic activities were evaluated.

2Superoxide Dismutase Mimetic Activity of Cu(2)-Salicylic Acid Analogs

저자 : Chul Soon Yong

발행기관 : 한국약제학회 간행물 : DDS 연구를 통한 신약개발 0권 0호 발행 연도 : 1992 페이지 : pp. 65-76 (12 pages)

다운로드

(기관인증 필요)

키워드 보기
초록보기

The superoxide dismutase (SOD)-mimetic activities of copper complexes of a series of salicylic acid (SA) analogs were tested and compared to the activity of bovine erythrocyte SOD using ferricytochrome c reduction assay. Stability constants of copper complexes were measured potentiometrically using SCOGS2 program. In the presence of 10 g/ℓ albumin, all the copper complexes lost their SOD mimetic activities. Multiple regression analysis was employed for the statistical comparisons between the SOD mimetic activity and their physicochemical properties. Correlation exists for the SOD mimetic activity and steric parameter (E_s) and/or electronic parameter (Σσ) in xanthine/xanthine oxidase (XOD) system, demonstrating that E_s plays a key role in SOD activity whereas Σσ influences it to a lesser extent. The protective effect of copper complexes against membrane damage was measured by counting D-glucose released frm EGs. D-glucose and XOD were entrapped within EGs and acetaldehyde was used as a substrate for XOD. In this membrane model system using EGs, hydrophobic parameter (Σπ) is of most importance, producing parabolic equation while E_s and Σσ appear to play a minor role in protection against D-glucose release. In summary, to design an efficient SOD mimetic, stability, steric factor, lipophilicity and redox potential should be considered.

1
권호별 보기
가장 많이 인용된 논문

(자료제공: 네이버학술정보)

가장 많이 인용된 논문
| | | |
1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

다운로드

2미국의 비트코인 규제

(2006)홍길동심리학41회 피인용

다운로드

가장 많이 참고한 논문

(자료제공: 네이버학술정보)

가장 많이 참고한 논문

다운로드

2미국의 비트코인 규제

(2006)홍길동41회 피인용

다운로드

해당 간행물 관심 구독기관

내가 찾은 최근 검색어

최근 열람 자료

맞춤 논문

보관함

내 보관함
공유한 보관함

1:1문의

닫기